Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 1973 - 1973
Published: Nov. 28, 2024
If
the
billions
of
oligodendrocytes
(OLs)
populating
central
nervous
system
(CNS)
patients
could
express
their
feelings,
they
would
undoubtedly
tell
gene
therapists
about
frustration
with
other
neural
cell
populations,
neurons,
microglia,
or
astrocytes,
which
have
been
favorite
targets
transfer
experiments.
This
review
questions
why
OLs
left
out
most
therapy
attempts.
The
first
explanation
is
that
pathogenic
role
still
discussed
in
CNS
diseases.
Another
reason
so-called
ubiquitous
CAG,
CBA,
CBh,
CMV
promoters—widely
used
studies—are
unable
poorly
able
to
activate
transcription
episomal
transgene
copies
brought
by
adeno-associated
virus
(AAV)
vectors
OLs.
Accordingly,
expression
has
either
not
found
evaluated
studies
rodents
non-human
primates.
aims
current
are
give
rightful
place
among
cells
future
target
and
encourage
researchers
test
effect
OL
transduction
various
Nature Medicine,
Journal Year:
2024,
Volume and Issue:
30(6), P. 1622 - 1635
Published: May 17, 2024
Abstract
Neural–tumor
interactions
drive
glioma
growth
as
evidenced
in
preclinical
models,
but
clinical
validation
is
limited.
We
present
an
epigenetically
defined
neural
signature
of
glioblastoma
that
independently
predicts
patients’
survival.
use
reference
signatures
cells
to
deconvolve
tumor
DNA
and
classify
samples
into
low-
or
high-neural
tumors.
High-neural
glioblastomas
exhibit
hypomethylated
CpG
sites
upregulation
genes
associated
with
synaptic
integration.
Single-cell
transcriptomic
analysis
reveals
a
high
abundance
malignant
stemcell-like
glioblastoma,
primarily
the
lineage.
These
are
further
classified
neural-progenitor-cell-like,
astrocyte-like
oligodendrocyte-progenitor-like,
alongside
oligodendrocytes
excitatory
neurons.
In
line
these
findings,
engender
neuron-to-glioma
synapse
formation
vitro
vivo
show
unfavorable
survival
after
xenografting.
patients,
decreased
overall
progression-free
tumors
also
increased
functional
connectivity
magnetencephalography
resting-state
magnet
resonance
imaging
can
be
detected
via
analytes
brain-derived
neurotrophic
factor
plasma.
The
prognostic
importance
was
validated
patients
diagnosed
diffuse
midline
glioma.
Our
study
presents
high-grade
gliomas
prognostically
relevant.
likely
require
maximized
surgical
resection
approach
for
improved
outcomes.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Feb. 6, 2025
The
activity
of
neurons
in
the
vicinity
tumors
is
linked
to
a
spectrum
cellular
mechanisms,
including
facilitation
tumor
cell
proliferation,
synapse
formation,
angiogenesis,
and
macrophage
polarization.
This
review
consolidates
current
understanding
neuro-oncological
regulation,
underscoring
nuanced
interplay
between
neurological
oncological
processes
(termed
as
Cancer-Neuroscience).
First,
we
elucidated
how
nervous
system
accelerates
growth,
metastasis,
microenvironment
both
directly
indirectly
through
action
signaling
molecules.
Importantly,
neural
also
implicated
modulating
efficacy
therapeutic
interventions,
immunotherapy.
On
contrary,
potentially
has
suppressive
effect
on
tumorigenesis,
further
dual-edged
role
cancer
progression.
Consequently,
targeting
specific
molecules
within
regulatory
pathways
could
suppress
development.
Future
research
poised
explore
intricate
mechanisms
governing
neuro-tumor
interactions
more
deeply,
while
concurrently
refining
treatment
strategies
for
by
crosstalk
neurons.
Genes & Development,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 29, 2024
Glioblastoma
(GBM)
is
the
most
aggressive
primary
brain
cancer.
These
tumors
exhibit
high
intertumoral
and
intratumoral
heterogeneity
in
neoplastic
nonneoplastic
compartments,
low
lymphocyte
infiltration,
abundance
of
myeloid
subsets
that
together
create
a
highly
protumorigenic
immunosuppressive
microenvironment.
Moreover,
heterogeneous
GBM
cells
infiltrate
adjacent
tissue,
remodeling
neural
microenvironment
to
foster
tumor
electrochemical
coupling
with
neurons
metabolic
astrocytes,
thereby
driving
growth.
Here,
we
review
its
role
low-to-high-grade
glioma
transition,
concluding
discussion
challenges
therapeutically
targeting
outlining
future
research
opportunities.
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(1)
Published: Jan. 1, 2025
Abstract
The
adult
central
nervous
system
(CNS)
hosts
several
niches,
in
which
the
neural
stem
and
precursor
cells
(NPCs)
reside.
subventricular
zone
(SVZ)
lines
lateral
brain
ventricles
subgranular
(SGZ)
is
located
dentate
gyrus
of
hippocampus.
SVZ
SGZ
NPCs
replace
neurons
glia
homeostatic
as
well
diseased
or
injured
states.
Recently,
have
been
found
to
express
neurotransmitter
receptors,
respond
electrical
stimulation
interact
with
neurons,
suggesting
that
neuron‐NPC
communication
an
emerging
critical
regulator
NPC
biology.
In
this
review,
we
discuss
reports
demonstrate
neuronal
innervation
control
neurogenic
niches.
We
role
innervating
regulating
fates,
such
activation,
proliferation,
differentiation.
Our
review
focuses
primarily
on
niche
by
following
types:
glutamatergic,
GABAergic
projection
interneurons,
cholinergic,
dopaminergic,
serotonergic,
neuropeptidergic,
nitrergic,
noradrenergic.
also
origins
striatum,
cortex,
basal
ganglia,
raphe
nuclei,
substantia
nigra
ventral
tegmental
area,
hypothalamus,
locus
coeruleus.
highlights
various
roles
fates
a
spatiotemporal
manner
emphasizes
need
for
future
investigation
into
impact
gliogenesis.
image
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Tissues
maintain
their
function
through
interaction
with
microenvironment.
During
aging,
both
hair
follicles
and
blood
vessels
(BV)
in
skin
undergo
degenerative
changes.
However,
it
is
elusive
whether
the
changes
are
due
to
intrinsic
aging
or
respectively,
interactions.
To
explore
how
interact
regulate
angiogenesis
regeneration
during
aging.
Single-cell
RNA-sequencing
(scRNA-seq)
analyses
were
used
identify
declined
ability
of
dermal
papilla
(DP)
endothelial
cells
(ECs)
CellChat
CellCall
performed
investigate
between
DP
ECs.
metabolism
(scMetabolism)
analysis
iPATH
applied
analyze
downstream
metabolites
Hair-plucking
model
mouse
cell
organoid
for
functional
studies.
distance
ECs
decreased.
interacts
ECs,
decreased
EDN1-EDNRA
signaling
from
CTF1-IL6ST
ECs-secreted
EDN1
binds
DP-expressed
EDNRA
which
enhances
Taurine
(TA)
promote
regeneration.
DP-emitted
CTF1
ECs-expressed
IL6ST
activates
alpha-linolenic
acid
(ALA)
angiogenesis.
Activated
EDN1-EDNRA-TA
promotes
aged
cultures,
increased
CTF1-IL6ST-ALA
also
cultures.
Our
finding
reveals
reciprocal
interactions
DP.
releases
sensed
by
activate
TA
induces
regeneration,
while
emits
signal
received
enhance
ALA
study
provides
new
insights
into
mutualistic
cellular
crosstalk
vessels,
identifies
novel
contributing
normal
skin.
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 3, 2025
The
main
characteristics
of
Parkinson's
disease
(PD)
are
the
loss
dopaminergic
(DA)
neurons
and
abnormal
aggregation
cytosolic
proteins.
However,
exact
pathogenesis
PD
remains
unclear,
with
ferroptosis
emerging
as
one
key
factors
driven
by
iron
accumulation
lipid
peroxidation.
Glial
cells,
including
microglia,
astrocytes,
oligodendrocytes,
serve
supportive
cells
in
central
nervous
system
(CNS),
but
their
activation
can
lead
to
DA
neuron
death
ferroptosis.
This
paper
explores
interactions
between
glial
neurons,
reviews
changes
during
pathological
process
PD,
reports
on
how
regulate
through
homeostasis
opens
up
a
new
pathway
for
basic
research
therapeutic
strategies
disease.
