As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
ageing-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provide
foundation
developing
targeted
interventions
mental
well-being
an
population.
Ain Shams Engineering Journal,
Journal Year:
2024,
Volume and Issue:
15(10), P. 102955 - 102955
Published: July 14, 2024
Histopathology
image
analysis
is
paramount
importance
for
accurate
diagnosing
diseases
and
gaining
insight
into
tissue
properties.
The
significant
challenge
of
staining
variability
continues.
This
research
work
presents
a
new
method
that
merges
deep
learning
with
Reinhardstain
normalization,
aiming
to
revolutionize
histopathology
analysis.
multi-data
stream
attention-based
generative
adversarial
network
an
innovative
architecture
designed
enhance
histopathological
by
integrating
multiple
data
streams,
attention
mechanisms,
networks
improved
feature
extraction
quality.
Multi-data
capitalizes
on
mechanisms
process
multi-modal
efficiently,
enhancing
ensuring
robust
performance
even
in
the
presence
variations.
approach
excels
exact
disease
detection
classification,
emerging
as
invaluable
tool
both
clinical
diagnoses
endeavors
across
diverse
datasets.
obtained
accuracy
proposed
SCAN
dataset
97.75%,
BACH
99.50%
Break
His
99.66%.
significantly
advances
analysis,
offering
diagnostic
deeper
insights
networks.
enhances
extraction,
quality,
overall
effectiveness
medical
As
a
key
member
of
the
neurotrophin
family
in
central
nervous
system,
brain-derived
neurotrophic
factor
(BDNF)
plays
critical
role
maintenance
and
plasticity
system.
Its
innate
neuroprotective
advantage
can
also
be
shared
with
brain
when
normal
aging-dependent
processes
challenge
neural
circuits.
The
intricate
relationship
between
BDNF
resilience
during
aging
process
signifies
molecular
mechanisms
that
underlie
protection
function,
such
as
cognition,
movement
psychological
well-being.
is
crucial
for
neuronal
growth
survival,
it
promote
against
age-related
functional
decline
frailty,
even
if
fails
to
entirely
prevent
ageing-related
decline.
In
present
review,
we
discuss
function
from
perspective
how
may
aging.
We
emphasize
briefly
principal,
well-known
cellular
hallmarks
restrict
disabling
dynamics
enhance
overall
Insight
into
pathways
through
which
reduces
dysfunctions
and/or
improves
resilience,
provide
foundation
developing
targeted
interventions
mental
well-being
an
population.
