Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 27, 2024
Language: Английский
Comprehensive analytical chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Open Biology, Journal Year: 2025, Volume and Issue: 15(5)
Published: Jan. 1, 2025
Our current understanding of the functional morphology olfactory systems in arthropods largely relies on information obtained hexapods. Existing analyses pathway crustacean representatives have suggested that these animals share several corresponding anatomical elements with hexapod but latter likely feature a different wiring logic from receptor to glomerulus. This study sets out further explore diversity arthropod by presenting detailed morphological analysis peripheral and central pathways an emerging model system, peracarid Parhyale hawaiensis (Malacostraca). These all neuronal characterize malacostracan crustacean’s systems, simplicity this animal’s system provided unique opportunity quantify numbers sensilla associated sensory neurons, interneurons glomeruli. data showed number those is highly variable across individuals, contrasting more stable typically are characterized glomeruli individual identities constant numbers. We discuss possible steps needed for evolutionary transformation type into type.
Language: Английский
Citations
0
Cell and Tissue Research, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Language: Английский
Citations
0
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 24, 2024
Abstract Distinguishing between nectar and non-nectar odors is challenging for animals due to shared compounds varying ratios in complex mixtures. Changes production throughout the day - potentially many times within a forager’s lifetime add complexity. The honeybee olfactory system, containing fewer than 1,000 principal neurons early relay, antennal lobe (AL), must learn associate diverse volatile blends with rewards. Previous studies identified plasticity AL circuits, but its role odor learning remains poorly understood. Using biophysical computational network model, tuned by vivo electrophysiological data, live imaging of honeybee’s AL, we explored neural mechanisms functions system. Our findings revealed that when trained set rewarded unrewarded odors, inhibitory suppresses chemical while enhancing responses distinct compounds. This results improved pattern separation more concise code. calcium data support these predictions. Analysis graph convolutional performing an categorization task similar mechanism contrast enhancement. study provides insights into how reshapes coding efficient odors. Significance Statement By combining modeling, machine learning, electrophysiology analysis demonstrate associative nonassociative (AL) first relay insect system work together enhance Training AL’s specific environments enables suppression common components amplifying distinctive ones. sheds light on system’s ability adapt efficiently new odor-reward associations across environments, it proposes innovative, energy-efficient principles applicable artificial intelligence.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 26, 2024
Animals′ behaviours can vary greatly between even closely-related species. While changes in the sensory periphery have frequently been linked to species-specific behaviours, very little is known about if and how individual cell types central brain evolve. Here, we develop a set of advanced genetic tools compare homologous neurons Drosophila sechellia – which specialises on single fruit melanogaster . Through systematic morphological analysis olfactory projection (PNs), reveal that global anatomy these second-order conserved. However, high-resolution, quantitative comparisons identify striking case convergent rewiring PNs two distinct pathways critical for D. ′s host location. Calcium imaging labelling pre-synaptic sites evolved demonstrate novel functional connections with third-order partners are formed This work demonstrates peripheral evolution accompanied by highly-selective wiring facilitate ecological specialisation, paves way comparison other throughout nervous system.
Language: Английский
Citations
2
Nature, Journal Year: 2024, Volume and Issue: 634(8034), P. 547 - 548
Published: Oct. 9, 2024
Language: Английский
Citations
1
Current Opinion in Insect Science, Journal Year: 2024, Volume and Issue: unknown, P. 101291 - 101291
Published: Oct. 1, 2024
Language: Английский
Citations
1
Neuroscience Research, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Chemogenetics uses artificially-engineered proteins to modify the activity of cells, notably neurons, in response small molecules. Although a common set chemogenetic tools are G protein-coupled receptor-based DREADDs, there has been great hope for ligand-gated, ion channel-type that directly impact neuronal excitability. We have devised such technology by exploiting insect Ionotropic Receptors (IRs), highly divergent subfamily ionotropic glutamate receptors evolved detect diverse environmental chemicals. Here, we review series studies developing and applying this "IR-mediated activation" (IRNA) with Drosophila melanogaster IR84a/IR8a complex, which detects phenyl-containing ligands. also discuss how variants IRNA could be produced modifying composition IR using natural or engineered subunits, would enable artificial activation different cell populations brain distinct
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 14, 2024
Abstract The brain’s ability to prioritize behaviorally relevant sensory information is crucial for adaptive behavior, yet the underlying mechanisms remain unclear. Here, we investigated role of basal forebrain cholinergic neurons in modulating olfactory bulb (OB) circuits mice. Calcium imaging feedback axons OB revealed that their activity strongly correlated with orofacial movements, little responses passively experienced odor stimuli. However, when mice engaged an discrimination task, rapidly shifted response patterns from movement-correlated odor-aligned responses. Notably, these during task engagement were absent projecting dorsal cortex. level performance. Inactivation OB-projecting impaired performance and reduced granule cells. Thus, system dynamically modulates processing a modality-specific context-dependent manner, providing mechanism flexible prioritization.
Language: Английский
Citations
0