Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system DOI Creative Commons
Jana K. Sonner, Christina Mayer, Manuel A. Friese

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 31, 2024

Language: Английский

Panobinostat Attenuates Experimental Autoimmune Encephalomyelitis in Mice via Suppressing Oxidative Stress-Related Neuroinflammation and Mitochondrial Dysfunction DOI Open Access
Yanjia Shen,

Jiaying Zhao,

Ran Yang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12035 - 12035

Published: Nov. 9, 2024

Multiple sclerosis (MS) is an autoimmune disease mediated by T helper cells, which characterized neuroinflammation, axonal or neuronal loss, demyelination, and astrocytic gliosis. Histone deacetylase inhibitors (HDACis) are noted for their roles in easing inflammatory conditions suppressing the immune response. Panobinostat, HDACi, now being used treating multiple myeloma. Nevertheless, effect of panobinostat on diseases remains largely unclear. Thus, our research endeavored to determine if administration could prevent experimental encephalomyelitis (EAE) mice, one most commonly animal models MS, further explored underlying mechanisms. The EAE mice were generated then administered continuously with at a dosage 30 mg/kg 16 days. results indicated that markedly alleviated clinical symptoms inhibiting demyelination loss oligodendrocytes central nervous system (CNS). Moreover, decreased inflammation activation microglia astrocytes spinal cords mice. Mechanistically, treatment panobinosat significantly suppressed M1 microglial polarization blocking toll-like receptor 2 (TLR2)/myeloid differentiation factor 88 (MyD88)/interferon regulatory 5 (IRF5) pathway. Additionally, inhibited mitochondrial dysfunction reduced oxidative stress In conclusion, findings reveal ameliorates stress-linked neuroinflammation dysfunction.

Language: Английский

Citations

1
Sportizumab – Multimodal progressive exercise over 10 weeks decreases Th17 frequency and CD49d expression on CD8+ T cells in relapsing-remitting multiple sclerosis: A randomized controlled trial DOI Creative Commons
Sebastian Proschinger, Sergen Belen, Frederike Adammek

et al.

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

1
Kynurenine pathway dysregulation as a mechanistic link between cognitive impairment and brain damage: Implications for multiple sclerosis DOI Creative Commons
Marie Kupjetz, Tiffany Y. Wences Chirino, Niklas Joisten

et al.

Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 149415 - 149415

Published: Dec. 1, 2024

Language: Английский

Citations

1
Neuronal STING activation mediates inflammation-induced neurodegeneration via ferroptosis pathways in multiple sclerosis DOI Creative Commons
Weiyan Wang, Mengdi Guo,

Xiao Tu

et al.

Biophysics Reports, Journal Year: 2024, Volume and Issue: 10(6), P. 416 - 416

Published: Jan. 1, 2024

Language: Английский

Citations

0
Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system DOI Creative Commons
Jana K. Sonner, Christina Mayer, Manuel A. Friese

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 31, 2024

Language: Английский

Citations

0