Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential DOI Creative Commons

A. Cristina,

David Briand,

Aman Kukde

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

ABSTRACT Controlled proliferation of neural stem cells (NSCs) builds a functional nervous system during development. While their cellular niche is recognized as signalling hub, the contribution its structure and mechanics in regulating neurogenesis remains unexplored. The Drosophila larval central contains self-renewing NSCs close contact with cortex glial cells. Transcriptomics identified triad immunoglobulin superfamily cell adhesion molecules (Dpr10/Dpr6 glia DIP-α NSCs) which physically mechanically connect NSC membranes, acting mechanoregulators. Their disruption increases cortical tension, causing non-autonomous mitotic defects NSCs, characterized by abnormal spindle morphologies impaired progression. Additionally, elevated tensile forces increase Lamin content protective response also resulting nuclear deformation. Ultimately proliferative potential genome integrity are compromised. Our study reveals that native mechanical properties transmitted to regulate function. Graphical abstract

Language: Английский

Yin Yang 1: Function, Mechanisms, and Glia DOI Creative Commons
Ada G. Rodríguez-Campuzano, Francisco Castelán, Luisa C. Hernández‐Kelly

et al.

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: Feb. 4, 2025

Abstract Yin Yang 1 is a ubiquitously expressed transcription factor that has been extensively studied given its particular dual transcriptional regulation. involved in various cellular processes like cell cycle progression, differentiation, DNA repair, survival and apoptosis among others. Its malfunction or alteration leads to disease even malignant transformation. This essential for the proper central nervous system development function. The activity of depends on interacting partners, promoter environment chromatin structure, however, mechanistic not completely understood. In this review, we briefly discuss post-translational modifications, interactions, functions participation neurodevelopment. We also expression critical involvement physiology physiopathology glial cells, summarizing contribution different aspects

Language: Английский

Citations

0
Can the male germline offer insight into mammalian brain size expansion? DOI
Stephen J. Bush, Anne Goriely

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Recent advances in single‐cell transcriptomic data have greatly expanded our understanding of both spermatogenesis and the molecular mechanisms male infertility. However, this growing wealth could also shed light on a seemingly unrelated biological problem: genetic basis mammalian brain size expansion throughout evolution. It is now increasingly recognized that testis share many cellular similarities including pivotal roles for RAS/MAPK PI3K/AKT/mTOR pathways, mutations which are known to pronounced impact cell proliferation. Most notably, stem lineages organs, new been shown increase output over time. These include ‘selfish’ spermatogonial cells, disproportionately proportion mutant sperm, and—to draw parallel—human‐specific neural cells which, by increasing number neurons, implicated neocortical expansion. Here we speculate origin ‘expansion’‐associated germline as such, deeper controlling testicular turnover may yield fresh insight into biology evolution brain.

Language: Английский

Citations

0
miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells DOI Creative Commons

Xuanran Feng,

Xue Du, Xiaoyu Yang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 5, 2024

MicroRNAs (miRNAs) have emerged as an essential regulator of the cell fate commitment neural stem/progenitor cells (NPCs), although impacts certain miRNAs on NPCs remain vague. The aim this study is to investigate regulatory effects

Language: Английский

Citations

0
Adhesion-Controlled Mechanics of the Glial Niche Regulate Neural Stem Cell Proliferative Potential DOI Creative Commons

A. Cristina,

David Briand,

Aman Kukde

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

ABSTRACT Controlled proliferation of neural stem cells (NSCs) builds a functional nervous system during development. While their cellular niche is recognized as signalling hub, the contribution its structure and mechanics in regulating neurogenesis remains unexplored. The Drosophila larval central contains self-renewing NSCs close contact with cortex glial cells. Transcriptomics identified triad immunoglobulin superfamily cell adhesion molecules (Dpr10/Dpr6 glia DIP-α NSCs) which physically mechanically connect NSC membranes, acting mechanoregulators. Their disruption increases cortical tension, causing non-autonomous mitotic defects NSCs, characterized by abnormal spindle morphologies impaired progression. Additionally, elevated tensile forces increase Lamin content protective response also resulting nuclear deformation. Ultimately proliferative potential genome integrity are compromised. Our study reveals that native mechanical properties transmitted to regulate function. Graphical abstract

Language: Английский

Citations

0