Unveiling the rule of medication and mechanisms of Xin'an medical masters in treating rheumatoid arthritis: a novel approach using data mining and network pharmacology

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42938 - e42938

Published: Feb. 1, 2025

Language: Английский

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Assessment of sarcopenia in young patients with inflammatory arthritis: a cross-sectional study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 10, 2025

Sarcopenia is a disease characterized by decreasing muscle mass and strength or performance. The prevalence of sarcopenia in rheumatic diseases has been evaluated single using various diagnostic approaches, generating conflicting data. study aims to investigate young adults with inflammatory arthritis (IA) detect factors associated low strength. single-center, cross-sectional included 138 IA. Dynamometry Jamar hand dynamometer was used determine handgrip Thresholds for reduced were < 27 kg males 16 females. To skeletal index (SMI), dual photon X-ray absorptiometry (DXA) done such cut-off points 5.67 kg/m2 females 7.0 males. Patients both considered as sarcopenic. Logistic regression analyses estimated between factors. Statistical significance defined p-value 0.05. about 47% all IA significantly different juvenile idiopathic (JIA), spondyloarthritis (SpA), rheumatoid (RA) groups (p = 0.006). At multivariable analysis, body (BMI) (OR 0.84; CI 95% 0.72–0.86, p 0.02), bone mineral density (BMD) at femur neck 0.01; 0.001–0.268, 0.01), 25-hydroxyvitamin D (25(OH)D) 0.96; 0.93–0.98, 0.001), disability Health Assessment Questionnaire (HAQ) 14.54; 4.92–51.77, 0.001) increased risk sarcopenia. results our demonstrate high among patients In these participants, lower BMI, BMD, 25(OH)D concentration, higher HAQ linked

Language: Английский

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Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 203, P. 112729 - 112729

Published: March 11, 2025

Rheumatoid arthritis (RA) promotes the onset and progression of sarcopenia, yet mechanisms co-morbidity between RA sarcopenia are under-explored. Therefore, this study integrated Gene Expression Omnibus (GEO) Genome-wide association studies (GWAS) data to comprehensively identify shared genes, associated mechanisms, biological pathways in sarcopenia. Utilizing two GEO datasets-GSE226151, which includes 60 RNA-seq samples skeletal muscle from healthy aged, pre-sarcopenia, individuals, GSE55235, with 20 synovial tissue joints-we performed differentially expressed genes analysis, weighted gene co-expression network analysis crosstalk enrichment for these genes. Using relevant GWAS datasets, SMR analyses cis-eQTL were performed. We further validated identified key explored potential causal associations sarcopenia-related traits. 25 involved immune-inflammatory response pathways, including neutrophil extracellular trap formation Fc gamma receptor-mediated phagocytosis. six core genes: NCF1, FCGR2A, FCGR3A, SORL1, FCGR3B, ITGAX (PSMR < 0.05). showed that FCGR2A might have a negative appendicular lean mass, whole body fat-free positive (P Overall, is first reveal molecular identifying response-related pathways. Further conducted validate emerging as drug target RA-associated These findings provide new insights into comorbid offering therapeutic targets both conditions.

Language: Английский

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The Effects of Inflammation and Treatment on Adiposity, Obesity, and Sarcopenia in Patients with Autoimmune Rheumatic Disease

Current Treatment Options in Rheumatology, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 11, 2025

Language: Английский

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Practical utilization of sonography for the assessment of muscle diseases in rheumatology

Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102055 - 102055

Published: March 1, 2025

Language: Английский

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