Bone microarchitecture assessed by 3D high-resolution peripheral quantitative computed tomography (HR-pQCT) as predictor of fracture risk in patients with glucocorticoid-induced osteoporosis

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Association between bone mineral density and vascular health in rheumatoid arthritis

Singapore Medical Journal, Journal Year: 2025, Volume and Issue: 66(3), P. 147 - 153

Published: March 1, 2025

Rheumatoid arthritis (RA) is associated with heightened cardiovascular disease and increased susceptibility to osteoporosis, shared underlying mechanisms. This study aimed investigate the association between vascular function bone mineral density (BMD). We conducted a cross-sectional of 49 patients RA at Tan Tock Seng Hospital, Singapore. Endothelial was measured as reactive hyperaemia index (RHI)-endothelial peripheral arterial tonometry aortic stiffness carotid-femoral pulse wave velocity (cf-PWV) using SphygmoCor. Univariable multivariable linear regression analyses were performed evaluate associations BMD function. used natural logarithm RHI (lnRHI) cf-PWV response variables, each covariate, adjusting for body mass index, positive anti-cyclic citrullinated peptide, cumulative prednisolone dose, hydroxychloroquine use Systematic COronary Risk Evaluation 2. recruited (mean age 61.08 ± 8.20 years), whom 44 (89.80%) women 39 (81.25%) Chinese. Significant found lnRHI lumbar spine (β = 0.4289, P 0.037) total hip 0.7544, 0.014) in univariable analyses. Multivariable confirmed these associations, showing that lower 0.7303, 0.001), femoral neck 0.8694, 0.030) 0.8909, 0.010) significantly worse lnRHI. No significant cf-PWV. Lower endothelial dysfunction, but not RA. Further longitudinal studies are needed confirm understand

Language: Английский

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Exercise ameliorates osteopenia in mice via intestinal microbial-mediated bile acid metabolism pathway

Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1741 - 1759

Published: Jan. 2, 2025

Rationale: Physical exercise is essential for skeletal integrity and bone health. The gut microbiome, as a pivotal modulator of overall physiologic states, closely associated with homeostasis metabolism. However, the potential role intestinal microbiota in exercise-mediated gain remains unclear. Methods: We conducted depletion fecal transplantation (FMT) ovariectomy (OVX) mice aged to investigate whether transfer ecological traits could confer exercise-induced protective effects. study analyzed metabolic profiles via 16S rRNA gene sequencing LC-MS untargeted metabolomics identify key microbial communities metabolites responsible protection. Transcriptome RNA interference were employed explore molecular mechanisms. Results: found that hindered osteogenic benefits exercise, FMT from exercised osteoporotic effectively mitigated osteopenia. Comprehensive profiling microbiome metabolome revealed exercise-matched reshaped microecology landscape. Notably, alterations bile acid metabolism, specifically enrichment taurine ursodeoxycholic acid, mediated effects on mass. Mechanistically, activated apelin signaling pathway restored bone-fat balance recipient MSCs. Conclusion: Our underscored important microbiota-metabolic axis gain, heralding breakthrough treatment osteoporosis.

Language: Английский

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Risk-Weight Calculation of Candidate Risk Factors for Incidental Osteoporotic Fracture in Patients with Rheumatic Diseases: A Potentially Accurate Approach

Osteology, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5

Published: Jan. 27, 2025

Background and Objectives: To assess the risk of osteoporotic fractures in patients with rheumatic diseases (RDs), we introduced a new approach for predicting incident (OF), employing risk-weight calculation each candidate factor. Materials Methods: RD outpatients were picked up, their histories, including OFs, studied. A Cox regression analysis that evaluated factors was conducted multivariate model. The variants selected as showed statistical significance using univariate Using ratio or β-value p-value, different approaches to acquire total weight (TRW) patient determined compare sensitivity specificity among methods. cut-off index (COI) receiver operating characteristic analysis. Sensitivity OFs Kaplan–Meier survival Results: In 1228 patients, incidental OF occurred 179 (14.58%) who included. Factors significantly higher ratios history vertebral non-vertebral (p < 0.001), cognitive impairment anti-osteoporosis drug intervention rehabilitation 0.001). excellent best calculate multiplied by logarithm p-value based on 0.05, non-significant (sensitivity: 31.2%, specificity: 94.9%, area under curve (AUC): 0.774) compared 29.4%, 91.6%, 0.723, respectively, counted significant approach. Conclusions: This novel approach, which includes factors, can achieve more accurate accidental RDs.

Language: Английский

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Osteoporosis and Rheumatoid Arthritis: Mechanisms Underlying Osteoclast Differentiation and Activation or Factors Associated with Hip Fractures

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(4), P. 1138 - 1138

Published: Feb. 10, 2025

Osteoporosis is defined as a condition of increased risk fracture due to decreased bone strength. In developed countries, the number patients with osteoporosis and fragility fractures has been increasing in recent years growing elderly population, posing social challenge not only their families but also healthcare economy. can be divided into two categories: primary caused by aging or menopause secondary metabolic inflammatory diseases drugs such glucocorticoids. The majority have osteoporosis, pathogenesis postmenopausal factors associated elucidated. On other hand, rheumatoid arthritis (RA) one causes osteoporosis. RA chronic disease characterized joint swelling destruction. Most often, treatment focuses on suppressing these symptoms. However, physicians should aware patients, because (1) disease, which itself factor for osteoporosis; (2) glucocorticoids, are sometimes administered treat RA, (3) becoming older, an factor. A comprehensive understanding its requires elucidating mechanisms underlying osteoclast activation, drives development. Furthermore, identifying essential. This review summarizes fractures, associations between

Language: Английский

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Fracture Risk Linked to Proton Pump Inhibitors Versus H2 Receptor Antagonists in Autoimmune Rheumatic and Gastrointestinal Disease Patients

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(2)

Published: Feb. 1, 2025

ABSTRACT Objective To understand if proton pump inhibitors (PPIs) usage associated with an increased risk of fractures among adult patients diagnosed autoimmune rheumatic and gastrointestinal diseases, compared H2 receptor antagonists (H2RAs) usage. Methods We used the TriNetX US collaborative database for study, which includes detailed demographic information, diagnostic procedural data, medication details, laboratory results, genomic healthcare utilization metrics. analyzed 61 organizations to compare fracture risks PPIs H2RAs in adults, particularly those diseases. Propensity score matching acted as a control clinical variables. Results The study involved 1 717 598 patients, focusing on 16 299 who were new users after propensity matching. Over 24‐month follow‐up period, no significant differences observed between PPI H2RA groups overall cohort (hazard ratio, HR = 1.369, 95% confidence interval, CI 0.933–2.009). However, subgroup analysis indicated that senior (≥ 65 years) had been administered experienced significantly higher (HR 1.927 [1.153–3.221]), non‐vertebral 2.379 [1.214–4.661]), when their counterparts prescribed H2RAs. Notably, simultaneous use glucocorticoids further 4.273 [2.219–8.227]). Conclusions demonstrates diseases aged 65+ face using PPIs, there is intake glucocorticoids.

Language: Английский

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„Paradoxe Frakturen“: pathologische Frakturen unter antiosteoporotischer und antirheumatischer Therapie

Zeitschrift für Rheumatologie, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

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The Impact of Menopause on Autoimmune and Rheumatic Diseases

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 21, 2025

The prevalence of autoimmune and rheumatological diseases is significantly higher in women, likely due to the effect sex hormones influencing development function immune system, a phenomenon observed particularly during pregnancy. Oestrogens, particular, appear be major factor modulating response, as their receptors are present nearly all cells, where they regulate expression genes involved inflammation. However, there limited data on how menopause impacts diseases, despite evidence suggesting that menopausal perturbation hormone levels may lead conditions or alter course an already established disease. This review focuses rheumatic conditions, aiming provide comprehensive understanding influences onset, progression, clinical features diseases. best available for rheumatoid arthritis systemic lupus erythematosus, two paradigmatic which elicits opposite outcomes. Despite these data, notable lack research impact other inflammatory connective tissue gap highlights crucial area future unmet needs addressed. Understanding changes autoimmunity will improving management women.

Language: Английский

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Multi‐Core Functional Microspheres for Osteoporotic Bone Defects Therapy: From Local Treatment to Systematic Relief

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Bone repair in patients with osteoporosis is a major challenge. In this study, multi‐enhanced bioactive microsphere scaffolds (abbr. GMA MSs) composed of gelatin framework alendronate (ALN) and magnesium (Mg) spheres encapsulants are developed for repairing osteoporotic bone defects. The MSs prepared via the reverse microemulsion method photocuring process have uniform morphology. Hydrogen (H 2 ) generated from scavenged reactive oxygen species (ROS), regulated macrophage phenotype, inhibited phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt) nuclear factor kappa‐B (NF‐κB) signaling pathways, decreased expression pro‐inflammatory factors, thereby improving inflammatory microenvironment. Concurrently, alkaline enhancement ALN release osteoclast activity, released Mg 2+ promoted osteogenic differentiation, which synergistically restored balance metabolism alongside ALN. After filling into skull defects, significantly improved response notable tissue defects ovariectomized (OVX) mice. Notably, local treatment relieved systemic reduced overall loss these mice, highlighting substantial potential scaffold clinical

Language: Английский

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Progress in oral biomaterials for the treatment of metabolic bone diseases

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101499 - 101499

Published: April 1, 2025

Language: Английский

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