Lara D. Veeken,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Abstract
Objectives
To
investigate
the
association
between
risk
of
different
co-morbidities
and
diagnosis
rheumatoid
arthritis
(RA)
using
a
temporal
approach.
Methods
Retrospective,
case-control
study.
Data
were
extracted
from
all
healthcare
claims
for
Poland
2011-2021.
Prevalent
RA(n
=
262
265)
patients
examined
to
evaluate
morbidity
patterns.
Incident
15
879)
age-,
sex-
region-matched
controls
sampled
1:10
general
population
(GP).
Exposure
was
new-onset
RA
identified
by
interspaced,
repeat
prescription.
Follow-up
performed
in
bidirectional,
five-year
timeframe
diagnosis(Dx).
Results
is
associated
with
enhanced
multiple
organ
system
disorders
both
pre-
post-Dx,
especially
hematologic
(IRR
1.80,
95%
CI
1.58,
2.05),
pulmonary
1.57,
1.53,
1.62),
gastrointestinal
1.46,
1.60),
cardiovascular
1.25,
1.22,
1.27)
conditions.
appears
strongly
interstitial
lung
disease
(pre-Dx
IRR
2.97,
2.20,
4.02;
post-Dx
4.66,
3.91,
5.56)
inflammatory
bowel
1.61,
2.07;
2.12,
1.70,
2.63).
Enhanced
thyroid
cancer
1.29,
1.00,
1.66)
lymphoma
1.50,
1.20,
1.88)
observed,
contrast
reduced
colon
0.77,
0.62,
0.94).
Conclusion
comorbidities
observed
post-RA
Dx,
varying
patterns
across
systems.
These
data
highlight
multisystem
nature
warrant
research
into
causal,
bidirectional
relationships.
Autoimmunity Reviews,
Journal Year:
2025,
Volume and Issue:
24(5), P. 103775 - 103775
Published: Feb. 13, 2025
Rheumatoid
Arthritis
(RA)
is
a
persistent
autoimmune
inflammatory
disorder
that
arises
from
the
intricate
interaction
between
genetic
predisposition
and
environmental
influences.
The
progression
of
RA
can
be
delineated
into
four
distinct
phases:
initially,
influence
risk
factors;
followed
by
emergence
systemic
autoimmunity;
subsequently,
an
asymptomatic
phase;
ultimately,
manifestation
clinical
arthritis.
Recently,
role
mucosal
immunity
in
has
gained
significant
attention
research.
Evidence
published
studies
suggests
not
only
influences
onset
but
also
plays
crucial
its
progression.
Scholars
have
begun
to
unravel
links
barriers
gastrointestinal
tract,
respiratory
system,
oral
cavity.
Specifically,
shifts
microbiota,
dysfunction
barriers,
abnormal
activation
immune
tissues
are
all
implicated
pathogenesis
RA.Despite
this
growing
body
knowledge,
comprehensive
review
therapeutic
implications
yet
conducted.
This
emphasizes
driving
abnormalities
development
autoimmunity
rheumatoid
arthritis
(RA).
It
further
explores
potential
RA,
as
well
issues
challenges
need
addressed
current
research
field,
providing
new
perspective
targets
for
prevention
treatment
RA.
EJNMMI Research,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 18, 2025
Rheumatoid
arthritis
(RA)
is
a
common
chronic,
inflammatory
autoimmune
disease,
and
early
clinical
diagnosis
crucial
for
its
treatment.
CXCR4
expression
was
characterized
in
arthritic
mouse
models
joints
of
RA
patients,
[18
F]AIF-NOTA-QHA-04
specificity
assessed
non-malignant
cells
with
elevated
expression.
This
study
explored
the
application
CXCR4-targeted
PET
probe
monitoring
disease
activity
therapeutic
efficacy
RA.
To
this
aim,
metabolic
characteristics
correlation
uptake
severity
were
evaluated
by
imaging
mice.
potential
evaluating
further
investigated
mice
following
methotrexate
(MTX)
etanercept
(ETC)
significantly
increased
inflamed
collagen-induced
(CIA)
collagen-antibody
induced
(CAIA)
mice,
synovial
tissues
patients.
showed
high
CXCR4,
that
strongly
correlated
scores.
revealed
paralleled
activity,
decreasing
upon
remission.
Furthermore,
provided
earlier
more
sensitive
assessments
MTX
ETC
compared
to
traditional
methods.
The
promising
tool
monitoring,
sensitivity.
as
biomarker
response
underscores
value
personalized
medication
strategies
management
Diabetes
exacerbates
periodontitis
by
overexpressing
reactive
oxygen
species
(ROS),
which
leads
to
periodontal
bone
resorption.
Consequently,
it
is
imperative
relieve
inflammation
and
promote
alveolar
regeneration
comprehensively
for
the
development
of
diabetic
treatment
strategies.
Furthermore,
an
orderly
avoid
interference
between
these
two
processes
can
achieve
optimal
therapeutic
effect.
Thus,
we
constructed
a
sequential
sustained
release
system
based
on
zeolitic
imidazolate
framework-8
(ZIF-8)-modified
chitosan
thermosensitive
hydrogel
(TOOTH)
therapy
in
this
work.
Chemically
modified
tetracycline-3
(CMT-3)
platelet-derived
growth
factor-BB
(PDGF-BB)
were
loaded
ZIF-8
release,
respectively,
with
aim
reducing
facilitating
tissue
regeneration.
During
therapy,
CMT-3
first
escaped
from
due
degradation
diffusion
ROS
elimination.
Subsequently,
was
dissociated
under
acid
microenvironment,
PDGF-BB
sustainably
released
osteogenesis.
The
intervals
could
be
regulated
sizes
ZIF-8.
biocompatible
TOOTH
exhibited
favorable
effect
vitro
vivo.
sequentially
controlled
facilitated
holds
promise
promoting
offers
potential
clinical
translation.
Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
135(6)
Published: March 16, 2025
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disease
currently
with
no
universally
highly
effective
prevention
strategies.
Identifying
pathogenic
immune
phenotypes
in
at-risk
populations
prior
to
clinical
onset
crucial
establishing
Here,
we
applied
multimodal
single-cell
technologies
(mass
cytometry
and
CITE-Seq)
characterize
the
immunophenotypes
blood
from
individuals
(ARIs)
identified
through
presence
of
serum
antibodies
against
citrullinated
protein
antigens
(ACPAs)
and/or
first-degree
relative
(FDR)
status,
as
compared
patients
established
RA
people
healthy
control
group.
We
significant
cell
expansions
ARIs
controls,
including
CCR2+CD4+
T
cells,
peripheral
helper
(Tph)
type
1
CXCR5+CD8+
cells.
also
found
that
CD15+
classical
monocytes
were
specifically
expanded
ACPA-negative
FDRs,
an
activated
PAX5lo
naive
B
population
was
ACPA-positive
FDRs.
Further,
uncovered
molecular
phenotype
expressing
high
levels
Th17-
Th22-related
signature
transcripts
CCR6,
IL23R,
KLRB1,
CD96,
IL22.
Our
integrated
study
provides
promising
approach
identify
targets
improve
strategy
development
for
RA.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 20, 2025
Rheumatoid
arthritis
(RA)
is
a
complex
chronic
autoimmune
disease
that
remains
incurable
for
most
patients.
With
advances
in
our
understanding
of
the
disease’s
natural
history,
concept
pre-RA
has
emerged
as
window
opportunity
to
intervene
before
irreversible
joint
damage
occurs.
Numerous
studies
have
indicated
key
step
driving
autoimmunity
early
lies
at
an
extra-articular
site,
which
closely
related
regulatory
T
(Treg)
cell-established
immune
tolerance
gut
microbiota.
The
intricate
immunometabolic
crosstalk
between
Treg
cells
and
microbiota
beginning
be
understood,
with
re-recognition
metabolic
sensors
recent
years.
In
future,
deciphering
their
dialogue
may
help
elucidate
underlying
mechanisms
pre-RA.
Identifying
novel
biological
pathways
stage
will
bring
insights
into
restoring
tolerance,
thereby
potentially
curing
or
preventing
onset
RA.
