Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments DOI Creative Commons
Guoqing Li,

Yajuan Wan,

Alan Jiao

et al.

Published: May 22, 2025

ABSTRACT The immune microenvironment includes cells, cytokines, extracellular matrix, vesicles, etc. interactions between these components form a unique local microecology. Although immunity serves as the defense against external pathogens, aberrant activation often contributes to disease development. Chronic diseases, broad category of noncommunicable conditions characterized by long latency and prolonged course, are increasingly recognized for their intricate relationship with microenvironment. Herein, we comprehensively summarize how microenvironment, through its complex regulatory network, influences progression manifestation chronic diseases. We further explore potential targeting therapeutic strategy, aiming provide new insights directions prevention, diagnosis, treatment

Language: Английский

Immune mediated inflammatory diseases: moving from targeted biologic therapy, stem cell therapy to targeted cell therapy DOI Creative Commons
Zhihou Liang, Hui Xie, Dongze Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 7, 2025

Despite the advancements in targeted biologic therapy for immune-mediated inflammatory diseases (IMIDs), significant challenges persist, including drug maintenance, primary and secondary non-responses, adverse effects. Recent data have strengthened evidence supporting stem cell as an experimental salvage into a standard treatment option. preclinical clinical studies suggested that chimeric antigen receptor T (CAR-T) therapy, which depleting tissue bone marrow B cells, may lead to improvement, even inducing long-lasting remissions patients with IMIDs. In this review, we address unmet needs of delineate critical differences between transplantation CAR-T evaluate current status IMIDs explore its potential existing limitations.

Language: Английский

Citations

0
The role of age-associated B cells in systemic lupus erythematosus DOI
Q. Y. Su, Xinxin Zheng, Xiaoqing Han

et al.

Journal of Autoimmunity, Journal Year: 2025, Volume and Issue: 154, P. 103433 - 103433

Published: May 6, 2025

Language: Английский

Citations

0
Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments DOI Creative Commons
Guoqing Li,

Yajuan Wan,

Alan Jiao

et al.

Published: May 22, 2025

ABSTRACT The immune microenvironment includes cells, cytokines, extracellular matrix, vesicles, etc. interactions between these components form a unique local microecology. Although immunity serves as the defense against external pathogens, aberrant activation often contributes to disease development. Chronic diseases, broad category of noncommunicable conditions characterized by long latency and prolonged course, are increasingly recognized for their intricate relationship with microenvironment. Herein, we comprehensively summarize how microenvironment, through its complex regulatory network, influences progression manifestation chronic diseases. We further explore potential targeting therapeutic strategy, aiming provide new insights directions prevention, diagnosis, treatment

Language: Английский

Citations

0