Are Osteoarthritis Inflammation and Its Related Sensorimotor Interactions Both Noteworthy and Modifiable Key Players? DOI
Ray Marks

Published: May 22, 2025

Joints are sensitive structures whose qualitative and quantitative components depend not only on the harmonious interactions of hormones, enzymes, vitamins, minerals protein, but also stresses put upon them by function as well their intrinsic extrinsic neuromotor environments, activity integrity. This paper reviews some recent pathological insights regarding synovial joint’s lining its immune cellular responses that indicate when traumatized may evoke a possible unstoppable cascade inflammation cartilage destruction unless abated in timely way. One essential movement correlate especially fail to limit spread osteoarthritis oftentimes severe repercussions, namely muscle dysfunction is specifically discussed. Based what known we argue favor untapped utility efforts reverse or mitigate post traumatic arthritis, face persistent mechanical impacts.

Language: Английский

Nitazoxanide Modulates Mitochondrial Function and Inflammatory Metabolism in Chondrocytes from Patients with Osteoarthritis via AMPK/mTORC1 Signaling DOI Creative Commons

Ha Eun Kim,

Jong Yeong Lee,

Ga‐Yeon Son

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 512 - 512

Published: April 24, 2025

Osteoarthritis (OA) is a long-term degenerative condition of the joints, characterized by persistent inflammation, progressive cartilage breakdown, and impaired mitochondrial function. Recent studies have shown that hyperactivation mTORC1 pathway metabolic reprogramming chondrocytes contribute to disease progression. Nitazoxanide (NTZ), an oral antiparasitic agent approved Food Drug Administration, has anti-inflammatory protective effects in various situations; despite this, its application osteoarthritis yet be fully investigated. Here, we assessed therapeutic efficacy NTZ using IL-1β-stimulated primary derived from patients with OA. substantially reduced expression proinflammatory cytokines matrix metalloproteinases, restored membrane potential, reactive oxygen species levels. also effectively reversed IL-1β-induced glycolytic changes inhibiting glucose uptake GLUT1 expression. Mechanistically, inhibited activation increased AMPK phosphorylation. The siRNA-mediated knockdown negated NTZ-induced improvements, suggesting key upstream regulator actions NTZ. can, therefore, inhibit inflammatory dysfunction OA through AMPK-dependent signaling inhibition, highlighting potential as disease-modifying therapy for

Language: Английский

Citations

0
Asarum heterotropoides F. Schmidt Attenuates Osteoarthritis via Multi-Target Anti-inflammatory Actions: A Network Pharmacology and Experimental Validation DOI
Hee-Geun Jo,

Chae Yun Baek,

Sidra Ilyas

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119915 - 119915

Published: May 1, 2025

Language: Английский

Citations

0
Association of the Red blood cell distribution width with Osteoarthritis Risk: A Cross-sectional Study from NHANES 2009-2018 DOI

Wenda Li,

Chao Zhang, Peijian Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Background：Red blood cell distribution width (RDW) is considered a novel prognostic biomarker; however, the correlation between RDW and osteoarthritis (OA) has not been clearly revealed. Therefore, this study used data from National Health Nutrition Examination Survey (NHANES) 2009 to 2018 explore potential relationship OA in depth. Methods：This cohort included 13,700 eligible participants with valid 2009-2018. Logistic regression was OA, followed by subgroup analysis verify results. The accuracy of compared BMI assessed plotting receiver operating characteristic (ROC) curve. Additionally, restricted cubic spline (RCS) evaluate nonlinear two. Results：This involved participants. According our findings, positively correlated an increased risk OA,this positive persists even after adjusting for all covariates.Subgroup showed that prevalence persisted across groups different characteristics, confirming its validity populations. results indicated had higher levels non-OA revealed significant (P-nonlinear < 0.05). ROC curve analysis, superior predictor BMI. Conclusion: Our found are associated OA.

Language: Английский

Citations

0
Are Osteoarthritis Inflammation and Its Related Sensorimotor Interactions Both Noteworthy and Modifiable Key Players? DOI
Ray Marks

Published: May 22, 2025

Joints are sensitive structures whose qualitative and quantitative components depend not only on the harmonious interactions of hormones, enzymes, vitamins, minerals protein, but also stresses put upon them by function as well their intrinsic extrinsic neuromotor environments, activity integrity. This paper reviews some recent pathological insights regarding synovial joint’s lining its immune cellular responses that indicate when traumatized may evoke a possible unstoppable cascade inflammation cartilage destruction unless abated in timely way. One essential movement correlate especially fail to limit spread osteoarthritis oftentimes severe repercussions, namely muscle dysfunction is specifically discussed. Based what known we argue favor untapped utility efforts reverse or mitigate post traumatic arthritis, face persistent mechanical impacts.

Language: Английский

Citations

0