Nitazoxanide Modulates Mitochondrial Function and Inflammatory Metabolism in Chondrocytes from Patients with Osteoarthritis via AMPK/mTORC1 Signaling
Ha Eun Kim,
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Jong Yeong Lee,
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Ga‐Yeon Son
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et al.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(5), P. 512 - 512
Published: April 24, 2025
Osteoarthritis
(OA)
is
a
long-term
degenerative
condition
of
the
joints,
characterized
by
persistent
inflammation,
progressive
cartilage
breakdown,
and
impaired
mitochondrial
function.
Recent
studies
have
shown
that
hyperactivation
mTORC1
pathway
metabolic
reprogramming
chondrocytes
contribute
to
disease
progression.
Nitazoxanide
(NTZ),
an
oral
antiparasitic
agent
approved
Food
Drug
Administration,
has
anti-inflammatory
protective
effects
in
various
situations;
despite
this,
its
application
osteoarthritis
yet
be
fully
investigated.
Here,
we
assessed
therapeutic
efficacy
NTZ
using
IL-1β-stimulated
primary
derived
from
patients
with
OA.
substantially
reduced
expression
proinflammatory
cytokines
matrix
metalloproteinases,
restored
membrane
potential,
reactive
oxygen
species
levels.
also
effectively
reversed
IL-1β-induced
glycolytic
changes
inhibiting
glucose
uptake
GLUT1
expression.
Mechanistically,
inhibited
activation
increased
AMPK
phosphorylation.
The
siRNA-mediated
knockdown
negated
NTZ-induced
improvements,
suggesting
key
upstream
regulator
actions
NTZ.
can,
therefore,
inhibit
inflammatory
dysfunction
OA
through
AMPK-dependent
signaling
inhibition,
highlighting
potential
as
disease-modifying
therapy
for
Language: Английский
Asarum heterotropoides F. Schmidt Attenuates Osteoarthritis via Multi-Target Anti-inflammatory Actions: A Network Pharmacology and Experimental Validation
Hee-Geun Jo,
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Chae Yun Baek,
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Sidra Ilyas
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et al.
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119915 - 119915
Published: May 1, 2025
Language: Английский
Association of the Red blood cell distribution width with Osteoarthritis Risk: A Cross-sectional Study from NHANES 2009-2018
Wenda Li,
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Chao Zhang,
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Peijian Wang
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et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 8, 2025
Abstract
Background:Red
blood
cell
distribution
width
(RDW)
is
considered
a
novel
prognostic
biomarker;
however,
the
correlation
between
RDW
and
osteoarthritis
(OA)
has
not
been
clearly
revealed.
Therefore,
this
study
used
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2009
to
2018
explore
potential
relationship
OA
in
depth.
Methods:This
cohort
included
13,700
eligible
participants
with
valid
2009-2018.
Logistic
regression
was
OA,
followed
by
subgroup
analysis
verify
results.
The
accuracy
of
compared
BMI
assessed
plotting
receiver
operating
characteristic
(ROC)
curve.
Additionally,
restricted
cubic
spline
(RCS)
evaluate
nonlinear
two.
Results:This
involved
participants.
According
our
findings,
positively
correlated
an
increased
risk
OA,this
positive
persists
even
after
adjusting
for
all
covariates.Subgroup
showed
that
prevalence
persisted
across
groups
different
characteristics,
confirming
its
validity
populations.
results
indicated
had
higher
levels
non-OA
revealed
significant
(P-nonlinear
<
0.05).
ROC
curve
analysis,
superior
predictor
BMI.
Conclusion:
Our
found
are
associated
OA.
Language: Английский
Are Osteoarthritis Inflammation and Its Related Sensorimotor Interactions Both Noteworthy and Modifiable Key Players?
Published: May 22, 2025
Joints
are
sensitive
structures
whose
qualitative
and
quantitative
components
depend
not
only
on
the
harmonious
interactions
of
hormones,
enzymes,
vitamins,
minerals
protein,
but
also
stresses
put
upon
them
by
function
as
well
their
intrinsic
extrinsic
neuromotor
environments,
activity
integrity.
This
paper
reviews
some
recent
pathological
insights
regarding
synovial
joint’s
lining
its
immune
cellular
responses
that
indicate
when
traumatized
may
evoke
a
possible
unstoppable
cascade
inflammation
cartilage
destruction
unless
abated
in
timely
way.
One
essential
movement
correlate
especially
fail
to
limit
spread
osteoarthritis
oftentimes
severe
repercussions,
namely
muscle
dysfunction
is
specifically
discussed.
Based
what
known
we
argue
favor
untapped
utility
efforts
reverse
or
mitigate
post
traumatic
arthritis,
face
persistent
mechanical
impacts.
Language: Английский