
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: May 20, 2025
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: May 20, 2025
Language: Английский
Nature Reviews Urology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
1European Urology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Nocturia, defined as waking one or more times per night to urinate, is a prevalent and burdensome condition with few effective treatments. While the primary risk factor for nocturia advanced age, preclinical studies have addressed pathophysiological mechanisms of in older subjects. Here, we develop translational model using aging mice behavioral paradigm that enables circadian assessment voluntary urination group-housed animals. We discovered dampened diurnal regulation urinary behavior aged compared adult controls. Molecular analyses revealed disrupted expression canonical genes mouse kidney bladder tissues. Notably, identified age-related loss mechanosensory ion channel, Piezo 1, suggesting potential mechanism linking disruption altered sensitivity. Our results reveal role dysfunction identify 1 promising therapeutic target chronobiological intervention.
Language: Английский
Citations
0Nature Reviews Urology, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0European Urology Focus, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Citations
0Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: May 20, 2025
Language: Английский
Citations
0