Cell Research,
Journal Year:
2020,
Volume and Issue:
30(8), P. 639 - 648
Published: June 15, 2020
The
discovery
of
cancer
immune
surveillance
and
immunotherapy
has
opened
up
a
new
era
treatment.
Immunotherapies
modulate
patient's
system
to
specifically
eliminate
cells;
thus,
it
is
considered
very
different
approach
from
classic
therapies
that
usually
induce
DNA
damage
cause
cell
death
in
cell-intrinsic
manner.
However,
recent
studies
have
revealed
such
as
radiotherapy
chemotherapy
also
elicit
antitumor
immunity,
which
plays
an
essential
role
their
therapeutic
efficacy.
cytosolic
sensor
cyclic
GMP-AMP
synthase
(cGAS)
the
downstream
effector
Stimulator
Interferon
Genes
(STING)
been
determined
be
critical
for
this
interplay.
Here,
we
review
roles
cGAS-STING
pathway
during
tumorigenesis,
surveillance,
therapies.
We
highlight
responses
through
cGAS
activation.
Science,
Journal Year:
2019,
Volume and Issue:
363(6431)
Published: March 8, 2019
DNA
is
highly
immunogenic.
It
represents
a
key
pathogen-associated
molecular
pattern
(PAMP)
during
infection.
Host
can,
however,
also
act
as
danger-associated
(DAMP)
and
elicit
strong
inflammatory
responses.
The
cGAS-STING
pathway
has
emerged
major
that
detects
intracellular
DNA.
Here,
we
highlight
recent
advances
on
how
cGAS
STING
mediate
responses
these
are
regulated,
allowing
cells
to
readily
respond
infections
noxious
agents
while
avoiding
the
inappropriate
sensing
of
self-DNA.
A
particular
focus
placed
role
in
context
sterile
conditions.
Manipulating
or
may
open
door
for
new
therapeutic
strategies
treatment
acute
chronic
inflammation
relevant
many
human
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2021,
Volume and Issue:
6(1)
Published: July 9, 2021
Abstract
Genomic
instability
is
the
hallmark
of
various
cancers
with
increasing
accumulation
DNA
damage.
The
application
radiotherapy
and
chemotherapy
in
cancer
treatment
typically
based
on
this
property
cancers.
However,
adverse
effects
including
normal
tissues
injury
are
also
accompanied
by
chemotherapy.
Targeted
therapy
has
potential
to
suppress
cells’
damage
response
through
tailoring
patients
lacking
specific
functions.
Obviously,
understanding
broader
role
repair
became
a
basic
attractive
strategy
for
targeted
therapy,
particular,
raising
novel
hypothesis
or
theory
field
basis
previous
scientists’
findings
would
be
important
future
promising
druggable
emerging
targets.
In
review,
we
first
illustrate
timeline
steps
roles
promotion
developed,
then
summarize
mechanisms
regarding
associated
highlighting
proteins
behind
targeting
that
initiate
functioning
abnormally
duo
extrinsic
harm
environmental
factors,
also,
baseline
drift
leads
harmful
intrinsic
therapy.
addition,
clinical
therapeutic
drugs
effects,
as
well
scheme
relative
trials
were
intensive
discussed.
Based
background,
suggest
two
hypotheses,
namely
“environmental
gear
selection”
describe
pathway
evolution,
“DNA
drift”,
which
may
play
magnified
mediating
during
treatment.
This
new
shed
light
provide
much
better
more
comprehensive
holistic
view
promote
development
research
direction
overcoming
strategies
patients.
Immunological Reviews,
Journal Year:
2019,
Volume and Issue:
290(1), P. 24 - 38
Published: July 1, 2019
The
fact
that
a
subset
of
human
cancers
showed
evidence
for
spontaneous
adaptive
immune
response
as
reflected
by
the
T
cell-inflamed
tumor
microenvironment
phenotype
led
to
search
candidate
innate
pathways
might
be
driving
such
endogenous
responses.
Preclinical
studies
indicated
major
role
host
STING
pathway,
cytosolic
DNA
sensing
proximal
event
required
optimal
type
I
interferon
production,
dendritic
cell
activation,
and
priming
CD8+
cells
against
tumor-associated
antigens.
agonists
are
therefore
being
developed
novel
cancer
therapeutic,
greater
understanding
pathway
regulation
is
leading
broadened
list
regulatory
targets.
Early
phase
clinical
trials
intratumoral
already
showing
promise,
alone
in
combination
with
checkpoint
blockade.
Further
advancement
will
derive
from
deeper
biology
well
mechanisms
vs
resistance
individual
patients.
