Development and plasticity of the corpus callosum DOI Creative Commons
Noelia S. de León-Reyes, Lorena Bragg-Gonzalo, Marta Nieto

et al.

Development, Journal Year: 2020, Volume and Issue: 147(18)

Published: Sept. 15, 2020

ABSTRACT The corpus callosum (CC) connects the cerebral hemispheres and is major mammalian commissural tract. It facilitates bilateral sensory integration higher cognitive functions, often affected in neurodevelopmental diseases. Here, we review mechanisms that contribute to development of CC circuits animal models humans. These species comparisons reveal several commonalities. First, there an early period massive axonal projection. Second, a postnatal temporal window, varying between species, which callosal projections are selectively refined. Third, sensory-derived activity influences refinement. We also discuss how defects formation can lead mild or severe congenital malformations.

Language: Английский

GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex DOI Creative Commons

Zhe Ran S. Duan,

Alicia Che,

Philip Chu

et al.

Neuron, Journal Year: 2019, Volume and Issue: 105(1), P. 75 - 92.e5

Published: Nov. 25, 2019

Language: Английский

Citations

89
Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia DOI Creative Commons
Vanessa M. Puñal, Caitlin E. Paisley, Federica S. Brecha

et al.

PLoS Biology, Journal Year: 2019, Volume and Issue: 17(10), P. e3000492 - e3000492

Published: Oct. 18, 2019

Naturally occurring cell death is a fundamental developmental mechanism for regulating numbers and sculpting developing organs. This particularly true in the nervous system, where large of neurons oligodendrocytes are eliminated via apoptosis during normal development. Given profound impact upon these two major populations, it surprising that another type—the astrocyte—has rarely been studied. It presently unclear whether astrocytes subject to significant death, if so, how occurs. Here, we address questions using mouse retinal as our model system. We show total number declines by over 3-fold period spanning postnatal days 5–14. Surprisingly, do not die apoptosis, canonical underlying vast majority death. Instead, find microglia engulf promote their removal. Genetic ablation inhibits astrocyte leading larger population size at end period. However, completely blocked absence microglia, apparently due ability each other. Nevertheless, mice lacking showed anatomical changes network, with functional consequences astrocyte-associated vasculature hemorrhage. These results establish novel modality naturally demonstrate its importance formation integrity gliovascular network.

Language: Английский

Citations

82
The Multifaceted Roles of KCC2 in Cortical Development DOI Creative Commons
M Virtanen, Pavel Uvarov, Martina Mavrović

et al.

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(5), P. 378 - 392

Published: Feb. 24, 2021

KCC2, best known as the neuron-specific chloride-extruder that sets strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe molecular cellular mechanisms involved in multiple functions KCC2 splice variants, ranging from developmental apoptosis control early network events to formation plasticity cortical dendritic spines. The versatility actions at subcellular levels also evident mature neurons plasticity, disease, aging. Thus, has emerged one most important molecules shape overall phenotype.

Language: Английский

Citations

82
How development sculpts hippocampal circuits and function DOI
Rosa Cossart, Roustem Khazipov

Physiological Reviews, Journal Year: 2021, Volume and Issue: 102(1), P. 343 - 378

Published: July 19, 2021

In mammals, the selective transformation of transient experience into stored memory occurs in hippocampus, which develops representations specific events context they occur. this review, we focus on development hippocampal circuits and self-organized dynamics embedded within them since latter critically support role hippocampus learning memory. We first discuss evidence that adult cells are sculpted by as early during embryonic neurogenesis. argue these primary developmental programs provide a scaffold onto later external world can be grafted. Next, review different sequences at anatomical functional levels. cover period extending from neurogenesis migration to appearance phenotypic diversity their wiring networks. describe progressive emergence network sensorimotor-driven sharp waves place tracking relational information. outline critical turn points discontinuities journey, close formulating open questions. propose rewinding process helps understand main organization principles circuits.

Language: Английский

Citations

81
Development and plasticity of the corpus callosum DOI Creative Commons
Noelia S. de León-Reyes, Lorena Bragg-Gonzalo, Marta Nieto

et al.

Development, Journal Year: 2020, Volume and Issue: 147(18)

Published: Sept. 15, 2020

ABSTRACT The corpus callosum (CC) connects the cerebral hemispheres and is major mammalian commissural tract. It facilitates bilateral sensory integration higher cognitive functions, often affected in neurodevelopmental diseases. Here, we review mechanisms that contribute to development of CC circuits animal models humans. These species comparisons reveal several commonalities. First, there an early period massive axonal projection. Second, a postnatal temporal window, varying between species, which callosal projections are selectively refined. Third, sensory-derived activity influences refinement. We also discuss how defects formation can lead mild or severe congenital malformations.

Language: Английский

Citations

80