Olfactory receptor and circuit evolution promote host specialization

Nature, Journal Year: 2020, Volume and Issue: 579(7799), P. 402 - 408

Published: March 4, 2020

Language: Английский

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Sexual arousal gates visual processing during Drosophila courtship

Nature, Journal Year: 2021, Volume and Issue: 595(7868), P. 549 - 553

Published: July 7, 2021

Language: Английский

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Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila

Current Biology, Journal Year: 2024, Volume and Issue: 34(11), P. 2319 - 2329.e6

Published: April 29, 2024

Language: Английский

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How to turn an organism into a model organism in 10 ‘easy’ steps

Journal of Experimental Biology, Journal Year: 2020, Volume and Issue: 223(Suppl_1)

Published: Feb. 1, 2020

ABSTRACT Many of the major biological discoveries 20th century were made using just six species: Escherichia coli bacteria, Saccharomyces cerevisiae and Schizosaccharomyces pombe yeast, Caenorhabditis elegans nematodes, Drosophila melanogaster flies Mus musculus mice. Our molecular understanding cell division cycle, embryonic development, clocks metabolism all obtained through genetic analysis these species. Yet ‘big 6’ did not start out as model organisms (hereafter ‘model organisms’), so how they mature into such powerful systems? First, are abundant human commensals: bacteria in our gut, yeast beer bread, nematodes compost pile, kitchen mice walls. Because this, cheaply, easily rapidly bred laboratory addition amenable to analysis. How why should we add additional species this roster? We argue that specialist will reveal new secrets important areas biology with modern technological innovations like next-generation sequencing CRISPR-Cas9 genome editing, time is ripe move beyond big 6. In review, chart a 10-step path goal, own experience Aedes aegypti mosquito, which built organism for neurobiology one decade. Insights deadly disease vector require work mosquito itself rather than modeling its another

Language: Английский

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Evolution, developmental expression and function of odorant receptors in insects

Journal of Experimental Biology, Journal Year: 2020, Volume and Issue: 223(Suppl_1)

Published: Feb. 1, 2020

ABSTRACT Animals rely on their chemosensory system to discriminate among a very large number of attractive or repulsive chemical cues in the environment, which is essential respond with proper action. The olfactory sensory systems insects share significant similarities those vertebrates, although they also exhibit dramatic differences, such as molecular nature odorant receptors (ORs): insect ORs function heteromeric ion channels common Orco subunit, unlike G-protein-coupled found vertebrates. Remarkable progress has recently been made understanding evolution, development and receptor neurons (ORNs). These studies have uncovered diversity species, including eusocial that extensively sensing pheromones for social communication. However, further studies, notably functional analyses, are needed improve our origins Orco–OR system, mechanisms ORN fate determination, extraordinary behavioral responses cues.

Language: Английский

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Inverse resource allocation between vision and olfaction across the genus Drosophila

Nature Communications, Journal Year: 2019, Volume and Issue: 10(1)

Published: March 11, 2019

Abstract Divergent populations across different environments are exposed to critical sensory information related locating a host or mate, as well avoiding predators and pathogens. These signals generate evolutionary changes in neuroanatomy behavior; however, few studies have investigated patterns of neural architecture that occur between systems, within large groups closely-related organisms. Here we examine 62 species the genus Drosophila describe an inverse resource allocation vision olfaction, which consistently observe at periphery, brain, during larval development. This variation was noted entire appears represent repeated, independent events, where one modality is selected for expense other. Moreover, provide evidence developmental genetic constraint through sharing single structure, eye-antennal imaginal disc. In addition, ecological implications visual olfactory bias, including potential impact on host-navigation courtship.

Language: Английский

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Neural Evolution of Context-Dependent Fly Song

Current Biology, Journal Year: 2019, Volume and Issue: 29(7), P. 1089 - 1099.e7

Published: March 14, 2019

Highlights•Genetic reagents target homologous neurons in multiple Drosophila species•Homologous descending drive distinct fly songs a similar social context•Evolutionary changes downstream of the cause song differences•Courtship circuit multifunctionality may facilitate rapid evolutionSummaryIt is unclear where nervous system evolutionary tend to occur. To localize source neural evolution that has generated divergent behaviors, we developed new approach label and functionally manipulate across species. We examined courtship two species sing types localized relevant function intrinsic physiology these neurons. This change causes different produce motor patterns contexts. Artificial stimulation drives types, suggesting multifunctional properties circuits types.

Language: Английский

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Expanding evolutionary neuroscience: insights from comparing variation in behavior

Neuron, Journal Year: 2021, Volume and Issue: 109(7), P. 1084 - 1099

Published: Feb. 21, 2021

Neuroscientists have long studied species with convenient biological features to discover how behavior emerges from conserved molecular, neural, and circuit level processes. With the advent of new tools, viral vectors gene editing automated behavioral analyses, there has been a recent wave interest in developing new, "nontraditional" model species. Here, we advocate for complementary approach development, that is, clade as way integrate an evolutionary comparative neurobiological experiments. Capitalizing on natural variation investing experimental tools clades will be valuable strategy next generation neuroscience discovery.

Language: Английский

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Molecular mechanisms of olfactory detection in insects: beyond receptors

Open Biology, Journal Year: 2020, Volume and Issue: 10(10)

Published: Oct. 1, 2020

Insects thrive in diverse ecological niches large part because of their highly sophisticated olfactory systems. Over the last two decades, a major focus study insect olfaction has been on role receptors mediating neuronal responses to environmental chemicals. In vivo , these operate specialized structures, called sensilla, which comprise neurons and non-neuronal support cells, extracellular lymph fluid precisely shaped cuticle. While sensilla are inherent odour sensing insects, we only just beginning understand construction function. Here, review recent work that illuminates how odour-evoked activity is impacted by sensillar morphology, biochemistry, accessory signalling molecules physiological crosstalk between cells. These advances reveal multi-layered molecular cellular mechanisms determine selectivity, sensitivity dynamic modulation insects.

Language: Английский

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A short guide to insect oviposition: when, where and how to lay an egg

Journal of Neurogenetics, Journal Year: 2019, Volume and Issue: 33(2), P. 75 - 89

Published: April 3, 2019

Egg-laying behavior is one of the most important aspects female behavior, and has a profound impact on fitness species. As such, it controlled by several layers regulation. Here, we review recent advances in our understanding insect neural circuits that control when, where how to lay an egg. We also outline outstanding open questions about egg-laying decisions, speculate possible underpinnings can drive diversification oviposition behaviors through evolution.

Language: Английский

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