Nature reviews. Neuroscience, Journal Year: 2019, Volume and Issue: 20(2), P. 94 - 108
Published: Jan. 14, 2019
Language: Английский
The Lancet, Journal Year: 2021, Volume and Issue: 397(10284), P. 1577 - 1590
Published: March 2, 2021
Language: Английский
Citations
3039
Cell, Journal Year: 2019, Volume and Issue: 179(2), P. 312 - 339
Published: Sept. 26, 2019
Language: Английский
Citations
2351
Nature Neuroscience, Journal Year: 2018, Volume and Issue: 21(10), P. 1380 - 1391
Published: Sept. 17, 2018
Language: Английский
Citations
755
Science, Journal Year: 2020, Volume and Issue: 370(6512), P. 50 - 56
Published: Oct. 2, 2020
Sleep is evolutionarily conserved across all species, and impaired sleep a common trait of the diseased brain. quality decreases as we age, disruption regular architecture frequent antecedent to onset dementia in neurodegenerative diseases. The glymphatic system, which clears brain protein waste products, mostly active during sleep. Yet system degrades with suggesting causal relationship between disturbance symptomatic progression dementias. ties that bind sleep, aging, clearance, aggregation have shed new light on pathogenesis broad range diseases, for failure may constitute therapeutically targetable final pathway.
Language: Английский
Citations
657
Nature, Journal Year: 2019, Volume and Issue: 572(7767), P. 62 - 66
Published: July 24, 2019
Language: Английский
Citations
608
Nature Immunology, Journal Year: 2019, Volume and Issue: 20(9), P. 1100 - 1109
Published: July 29, 2019
Language: Английский
Citations
581
Signal Transduction and Targeted Therapy, Journal Year: 2019, Volume and Issue: 4(1)
Published: Aug. 23, 2019
Abstract Alzheimer’s disease (AD) is a neurodegenerative characterized by progressive memory loss along with neuropsychiatric symptoms and decline in activities of daily life. Its main pathological features are cerebral atrophy, amyloid plaques, neurofibrillary tangles the brains patients. There various descriptive hypotheses regarding causes AD, including cholinergic hypothesis, tau propagation mitochondrial cascade calcium homeostasis neurovascular inflammatory metal ion lymphatic system hypothesis. However, ultimate etiology AD remains obscure. In this review, we discuss related clinical trials. Wealthy puzzles lessons have made it possible to develop explanatory theories identify potential strategies for therapeutic interventions AD. The combination hypometabolism autophagy deficiency likely be causative factor We further propose that fluoxetine, selective serotonin reuptake inhibitor, has treat
Language: Английский
Citations
571
The Journal of Experimental Medicine, Journal Year: 2020, Volume and Issue: 217(4)
Published: March 25, 2020
The blood vessels vascularizing the central nervous system exhibit a series of distinct properties that tightly control movement ions, molecules, and cells between parenchyma. This “blood–brain barrier” is initiated during angiogenesis via signals from surrounding neural environment, its integrity remains vital for homeostasis protection throughout life. Blood–brain barrier dysfunction contributes to pathology in range neurological conditions including multiple sclerosis, stroke, epilepsy, has also been implicated neurodegenerative diseases such as Alzheimer’s disease. review will discuss current knowledge key unanswered questions regarding blood–brain health
Language: Английский
Citations
561
Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 20(1), P. 49 - 65
Published: Nov. 20, 2018
Language: Английский
Citations
532
Cell, Journal Year: 2020, Volume and Issue: 182(2), P. 270 - 296
Published: July 1, 2020
Language: Английский
Citations
515