Identification of essential sites of lipid peroxidation in ferroptosis

Nature Chemical Biology, Journal Year: 2023, Volume and Issue: 19(6), P. 719 - 730

Published: Feb. 6, 2023

Language: Английский

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Nucleotide metabolism: a pan-cancer metabolic dependency

Nature reviews. Cancer, Journal Year: 2023, Volume and Issue: 23(5), P. 275 - 294

Published: March 27, 2023

Language: Английский

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Ferroptosis in liver disease: new insights into disease mechanisms

Cell Death Discovery, Journal Year: 2021, Volume and Issue: 7(1)

Published: Oct. 5, 2021

Abstract Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel form of iron-dependent cell death, which morphologically, genetically, biochemically distinct from other well-known death. In recent years, has been quickly gaining attention in the field liver diseases, as predisposed to oxidative injury generally, primary characteristic most major diseases. current review, we first delineate three cellular defense mechanisms against (GPx4 mitochondria cytosol, FSP1 on plasma membrane, DHODH mitochondria), along with four canonical modulators (system Xc − , nuclear factor erythroid 2-related 2, p53, GTP cyclohydrolase-1). Next, review progress studies delineating molecular underlying pathophysiology several common diseases including ischemia/reperfusion-related (IRI), nonalcoholic fatty disease (NAFLD), alcoholic (ALD), hemochromatosis (HH), drug-induced (DILI), hepatocellular carcinoma (HCC). Furthermore, also highlight both challenges promises that emerged should be addressed pursued future investigations before regulation could adopted an effective therapeutic target clinical practice.

Language: Английский

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Recent progress in ferroptosis: inducers and inhibitors

Cell Death Discovery, Journal Year: 2022, Volume and Issue: 8(1)

Published: Dec. 29, 2022

Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous interest in disease treatment research communities pursuit to reveal the mechanism key targets because closely related pathophysiological processes many diseases. Recent studies have shown some targets, such as glutathione peroxidase 4 (GPX4) System Xc-, several inducers inhibitors been developed regulate these targets. With emergence on made developments. The selection use are very important for work. This paper briefly introduces regulatory metabolic pathway, lists categorizes commonly used recently inhibitors, discusses their medical application. ends with potential future direction ferroptosis.

Language: Английский

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Persister cancer cells: Iron addiction and vulnerability to ferroptosis

Molecular Cell, Journal Year: 2021, Volume and Issue: 82(4), P. 728 - 740

Published: Dec. 28, 2021

Language: Английский

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