Cell,
Journal Year:
2023,
Volume and Issue:
186(13), P. 2911 - 2928.e20
Published: June 1, 2023
Animals
with
complex
nervous
systems
demand
sleep
for
memory
consolidation
and
synaptic
remodeling.
Here,
we
show
that,
although
the
Caenorhabditis
elegans
system
has
a
limited
number
of
neurons,
is
necessary
both
processes.
In
addition,
it
unclear
if,
in
any
system,
collaborates
experience
to
alter
synapses
between
specific
neurons
whether
this
ultimately
affects
behavior.
C.
have
defined
connections
well-described
contributions
We
that
spaced
odor-training
post-training
induce
long-term
memory.
Memory
consolidation,
but
not
acquisition,
requires
pair
interneurons,
AIYs,
which
play
role
odor-seeking
worms
consolidate
memory,
odor
conditioning
are
required
diminish
inhibitory
AWC
chemosensory
AIYs.
Thus,
demonstrate
living
organism
events
immediately
after
training
drive
structures.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 28, 2022
Behavioral
individuality
is
a
ubiquitous
phenomenon
in
animal
populations,
yet
the
origins
and
developmental
trajectories
of
individuality,
especially
very
early
life,
are
still
black
box.
Using
high-resolution
tracking
system,
we
mapped
behavioral
genetically
identical
fish
(Poecilia
formosa),
separated
immediately
after
birth
into
environments,
over
first
10
weeks
their
life
at
3
s
resolution.
We
find
that
(i)
strong
present
day
birth,
(ii)
differences
1
predict
behavior
up
to
least
later,
(iii)
patterns
strengthen
gradually
time.
Our
results
establish
null
model
for
how
can
develop
absence
genetic
environmental
variation
provide
experimental
evidence
later-in-life
be
strongly
shaped
by
factors
pre-dating
like
maternal
provisioning,
epigenetics
pre-birth
stochasticity.
Current Opinion in Insect Science,
Journal Year:
2022,
Volume and Issue:
54, P. 100968 - 100968
Published: Sept. 13, 2022
Methods
to
acquire
and
process
synaptic-resolution
electron-microscopy
datasets
have
progressed
very
rapidly,
allowing
production
annotation
of
larger,
more
complete
connectomes.
More
accurate
neuronal
matching
techniques
are
enriching
cell
type
data
with
gene
expression,
neuron
activity,
behaviour
developmental
information,
providing
ways
test
hypotheses
circuit
function.
In
a
variety
behaviours
such
as
learned
innate
olfaction,
navigation
sexual
behaviour,
connectomics
has
already
revealed
interconnected
modules
hierarchical
structure,
recurrence
integration
sensory
streams.
Comparing
individual
connectomes
determine
which
features
robust
variable
is
one
key
research
area;
new
work
in
comparative
across
development,
experience,
sex
species
will
establish
strong
links
between
connectivity
brain
Cell,
Journal Year:
2023,
Volume and Issue:
186(12), P. 2574 - 2592.e20
Published: May 15, 2023
Serotonin
influences
many
aspects
of
animal
behavior.
But
how
serotonin
acts
on
its
diverse
receptors
across
the
brain
to
modulate
global
activity
and
behavior
is
unknown.
Here,
we
examine
release
in
C.
elegans
alters
brain-wide
induce
foraging
behaviors,
like
slow
locomotion
increased
feeding.
Comprehensive
genetic
analyses
identify
three
core
(MOD-1,
SER-4,
LGC-50)
that
upon
others
(SER-1,
SER-5,
SER-7)
interact
with
them
this
SER-4
induces
behavioral
responses
sudden
increases
release,
whereas
MOD-1
persistent
release.
Whole-brain
imaging
reveals
widespread
serotonin-associated
dynamics,
spanning
networks.
We
map
all
sites
receptor
expression
connectome,
which,
together
synaptic
connectivity,
helps
predict
which
neurons
show
activity.
These
results
reveal
at
defined
a
connectome
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(9)
Published: March 1, 2023
Many
animals
perceive
odorant
molecules
by
collecting
information
from
ensembles
of
olfactory
neurons,
where
each
neuron
uses
receptors
that
are
tuned
to
recognize
certain
with
different
binding
affinity.
Olfactory
systems
able,
in
principle,
detect
and
discriminate
diverse
odorants
using
combinatorial
coding
strategies.
We
have
combined
microfluidics
multineuronal
imaging
study
the
ensemble-level
representations
at
sensory
periphery
nematode
Caenorhabditis
elegans
.
The
collective
activity
C.
chemosensory
neurons
reveals
high-dimensional
across
a
broad
space
molecules.
reveal
tuning
properties
dose-response
curves
odorants.
describe
unique
contribution
an
code
for
volatile
show
natural
stimuli,
set
pheromones,
also
encoded
ensemble.
integrated
contains
sufficient
robustly
encode
intensity
identity
chemical
stimuli.
Cell,
Journal Year:
2023,
Volume and Issue:
186(13), P. 2911 - 2928.e20
Published: June 1, 2023
Animals
with
complex
nervous
systems
demand
sleep
for
memory
consolidation
and
synaptic
remodeling.
Here,
we
show
that,
although
the
Caenorhabditis
elegans
system
has
a
limited
number
of
neurons,
is
necessary
both
processes.
In
addition,
it
unclear
if,
in
any
system,
collaborates
experience
to
alter
synapses
between
specific
neurons
whether
this
ultimately
affects
behavior.
C.
have
defined
connections
well-described
contributions
We
that
spaced
odor-training
post-training
induce
long-term
memory.
Memory
consolidation,
but
not
acquisition,
requires
pair
interneurons,
AIYs,
which
play
role
odor-seeking
worms
consolidate
memory,
odor
conditioning
are
required
diminish
inhibitory
AWC
chemosensory
AIYs.
Thus,
demonstrate
living
organism
events
immediately
after
training
drive
structures.
