SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron

Cell, Journal Year: 2022, Volume and Issue: 185(5), P. 847 - 859.e11

Published: Jan. 24, 2022

Language: Английский

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SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(8), P. 1161 - 1179

Published: July 7, 2022

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone public health response to COVID-19. The emergence hypermutated, increasingly transmissible variants concern (VOCs) threaten this strategy. Omicron (B.1.1.529), fifth VOC be described, harbours multiple amino acid mutations in spike, half which lie within receptor-binding domain. Here we demonstrate substantial evasion neutralization by BA.1 and BA.2 vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 mRNA-1273. These data were mirrored reduction real-world vaccine effectiveness that was partially restored booster vaccination. did not induce cell syncytia favoured TMPRSS2-independent endosomal entry pathway, these phenotypes mapping distinct regions protein. Impaired fusion determined domain, while mapped S2 Such marked changes antigenicity replicative biology may underlie rapid global spread altered pathogenicity variant.

Language: Английский

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Humoral and cellular immune memory to four COVID-19 vaccines

Cell, Journal Year: 2022, Volume and Issue: 185(14), P. 2434 - 2451.e17

Published: May 27, 2022

Language: Английский

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SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons

New England Journal of Medicine, Journal Year: 2022, Volume and Issue: 386(7), P. 698 - 700

Published: Jan. 12, 2022

Language: Английский

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Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

Science Immunology, Journal Year: 2022, Volume and Issue: 7(69)

Published: Feb. 3, 2022

The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune escape. Here, we studied neutralizing antibodies and T cell responses targeting SARS-CoV-2 D614G [wild type (WT)] the Beta, Delta, variants of concern a cohort 60 health care workers after immunization with ChAdOx-1 S, Ad26.COV2.S, mRNA-1273, or BNT162b2. High binding antibody levels against WT spike (S) were detected 28 days vaccination both mRNA vaccines (mRNA-1273 BNT162b2), which substantially decreased 6 months. In contrast, lower Ad26.COV2.S but did not wane. Neutralization assays showed consistent cross-neutralization Beta Delta variants, neutralization was significantly absent. BNT162b2 booster either two mRNA-1273 immunizations Ad26.COV2 priming partially restored variant, still up to 17-fold compared WT. SARS-CoV-2-specific cells months all regimens, more detection specific CD4

Language: Английский

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Covid-19 Vaccines — Immunity, Variants, Boosters

New England Journal of Medicine, Journal Year: 2022, Volume and Issue: 387(11), P. 1011 - 1020

Published: Aug. 31, 2022

T he coronavirus disease 2019 (Covid-19) pandemic has claimed an estimated 15 million lives, including more than 1 lives in the United States alone.The rapid development of multiple Covid-19 vaccines been a triumph biomedical research, and billions vaccine doses have administered worldwide.Challenges facing field include inequitable distribution, hesitancy, waning immunity, emergence highly transmissible viral variants that partially escape antibodies.This review summarizes current state knowledge about immune responses to importance both humoral cellular immunity for durable protection against severe disease. A nti v ir l Immunit yThe system is broadly divided into innate adaptive systems.Innate are first line defense viruses rapidly triggered when pattern-recognition receptors, such as toll-like recognize pathogen-associated molecular patterns.Innate antiviral includes secretion type I interferons, cytokines, certain responses, neutrophils, monocytes macrophages, dendritic cells, natural killer cells. Adaptive second viruses, involve antigen-specific recognition epitopes.Adaptive two complementary branches system: immunity.Humoral acute respiratory syndrome 2 (SARS-CoV-2) antibodies bind SARS-CoV-2 spike protein either neutralize virus or eliminate it through other effector mechanisms. 2,3ellular virus-specific B cells which provide long-term immunologic memory expand on reexposure antigen.B produce antibodies, CD8+ directly virally infected CD4+ help support responses.5][6][7] For variant largely escapes neutralizing may be particularly important longterm

Language: Английский

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Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(7), P. 1491 - 1500

Published: April 8, 2022

Language: Английский

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Clinical outcomes associated with SARS-CoV-2 Omicron (B.1.1.529) variant and BA.1/BA.1.1 or BA.2 subvariant infection in Southern California

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(9), P. 1933 - 1943

Published: June 8, 2022

Language: Английский

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SARS-CoV-2 viral load and shedding kinetics

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: unknown

Published: Dec. 2, 2022

Language: Английский

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Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(6), P. 1297 - 1302

Published: March 23, 2022

Language: Английский

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