mSphere,
Journal Year:
2022,
Volume and Issue:
7(3)
Published: May 19, 2022
To
understand
reinfection
rates
and
correlates
of
protection
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
we
established
eight
different
longitudinal
cohorts
in
2020
under
the
umbrella
PARIS
(Protection
Associated
with
Rapid
Immunity
to
SARS-CoV-2)/SPARTA
(SARS
SeroPrevalence
And
Respiratory
Tract
Assessment)
studies.
Here,
describe
PARIS/SPARTA
cohorts,
harmonized
assays
analysis
that
are
performed
across
as
well
case
definitions
SARS-CoV-2
infection
have
been
by
team
investigators.
Frontiers in Bacteriology,
Journal Year:
2023,
Volume and Issue:
2
Published: Oct. 9, 2023
Tackling
antimicrobial
resistance
requires
the
development
of
new
drugs
and
vaccines.
Artificial
intelligence
(AI)
assisted
computational
approaches
offer
an
alternative
to
traditionally
empirical
drug
vaccine
discovery
pipelines.
In
this
mini
review,
we
focus
on
increasingly
important
role
that
AI
now
plays
in
vaccines
provide
reader
with
methods
used
identify
candidate
candidates
for
selected
multi-drug
resistant
bacteria.
Cell Reports,
Journal Year:
2022,
Volume and Issue:
42(1), P. 111968 - 111968
Published: Dec. 26, 2022
The
leap
of
retroviruses
and
coronaviruses
from
animal
hosts
to
humans
has
led
two
ongoing
pandemics
tens
millions
deaths
worldwide.
Retrovirus
coronavirus
nucleocapsid
proteins
have
been
studied
extensively
as
potential
drug
targets
due
their
central
roles
in
virus
replication,
among
which
is
capacity
bind
respective
genomic
RNAs
for
packaging
into
nascent
virions.
This
review
focuses
on
fundamental
studies
these
how
intrinsic
abilities
condense
through
liquid-liquid
phase
separation
(LLPS)
contribute
viral
replication.
Therapeutic
targeting
condensates
methodological
advances
are
also
described
address
future
questions
contributes
Virus Evolution,
Journal Year:
2022,
Volume and Issue:
8(2)
Published: July 1, 2022
A
challenge
in
studying
viral
immune
escape
is
determining
how
mutations
combine
to
polyclonal
antibodies,
which
can
potentially
target
multiple
distinct
epitopes.
Here
we
introduce
a
biophysical
model
of
this
process
that
partitions
the
total
antibody
activity
by
epitope
and
then
quantifies
each
mutation
affects
against
epitope.
We
develop
software
use
deep
mutational
scanning
data
infer
these
properties
for
mixtures.
validate
using
computationally
simulated
experiment
demonstrate
it
enables
prediction
arbitrary
combinations
mutations.
The
described
paper
available
at
https://jbloomlab.github.io/polyclonal.
mSphere,
Journal Year:
2022,
Volume and Issue:
7(3)
Published: May 19, 2022
To
understand
reinfection
rates
and
correlates
of
protection
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
we
established
eight
different
longitudinal
cohorts
in
2020
under
the
umbrella
PARIS
(Protection
Associated
with
Rapid
Immunity
to
SARS-CoV-2)/SPARTA
(SARS
SeroPrevalence
And
Respiratory
Tract
Assessment)
studies.
Here,
describe
PARIS/SPARTA
cohorts,
harmonized
assays
analysis
that
are
performed
across
as
well
case
definitions
SARS-CoV-2
infection
have
been
by
team
investigators.
