Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction DOI Creative Commons
Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113066 - 113066

Published: Aug. 31, 2023

Fear-related disorders arise from inefficient fear extinction and have immeasurable social economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive extinction. We find that, already before conditioning, specific morphological, electrophysiological, transcriptomic patterns of cortical amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, the possibility rescue activating infralimbic impair prelimbic neurons.

Language: Английский

Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells DOI Creative Commons

Panthea Nemat,

Salimat Semenova,

Rolinka J. van der Loo

et al.

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108033 - 108033

Published: Feb. 1, 2025

Language: Английский

Citations

0
Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress DOI Creative Commons
Ting Wang, Zhihong Song, Xin Zhao

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(6)

Published: Oct. 13, 2023

Depression is a highly prevalent and disabling mental disorder, involving numerous genetic changes that are associated with abnormal functions in multiple regions of the brain. However, there little transcriptomic-wide characterization chronic social defeat stress (CSDS) to comprehensively compare transcriptional brain regions. Spatial transcriptomics (ST) was used reveal spatial difference gene expression control, resilient (RES) susceptible (SUS) mouse brains, annotated eight anatomical six cell types. The profiles uncovered CSDS leads synchrony different Then it identified inhibitory neurons synaptic were primarily affected by CSDS. Hippocampus (HIP), Isocortex, Amygdala (AMY) present more pronounced genes depressive psychiatric disorders than other Signalling communication between these three may play critical role susceptibility Taken together, this study provides important new insights into at ST level, which offers approach for understanding treating depression.

Language: Английский

Citations

7
Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder DOI
Sidney Krystal,

Laure Gracia,

Camille Piguet

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(11), P. 3344 - 3355

Published: May 9, 2024

Language: Английский

Citations

2
Identification of a stress-responsive subregion of the basolateral amygdala in male rats DOI
Robert J. Aukema, Gavin N. Petrie, Avi K. Matarasso

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(13), P. 1989 - 1999

Published: Aug. 9, 2024

Language: Английский

Citations

2
Synaptic and transcriptomic features of cortical and amygdala pyramidal neurons predict inefficient fear extinction DOI Creative Commons
Daniela Laricchiuta, Juliette Gimenez, Giuseppe Sciamanna

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(9), P. 113066 - 113066

Published: Aug. 31, 2023

Fear-related disorders arise from inefficient fear extinction and have immeasurable social economic costs. Here, we characterize mouse phenotypes that spontaneously show fear-independent behavioral traits predicting adaptive or maladaptive extinction. We find that, already before conditioning, specific morphological, electrophysiological, transcriptomic patterns of cortical amygdala pyramidal neurons predispose to fear-related disorders. Finally, by using an optogenetic approach, the possibility rescue activating infralimbic impair prelimbic neurons.

Language: Английский

Citations

6