Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: April 14, 2023
This
is
a
mini
review
on
the
biotechnological
aspects
of
most
extensively
developed
hemoglobin-based
oxygen
carriers
The
emphasis
recent
Polyhemoglobin-catalase-superoxide
dismutase-carbonic
anhydrase
(PolyHb-CAT-SOD-CA),
which
nanobiotechnological
complex
that
being
investigated
and
scaled
up
with
potential
for
clinical
use
as
nanobiotherapeutics.
Hemoglobin,
tetramer,
an
excellent
carrier.
However,
in
body
it
converted
into
toxic
dimers.
Diacid
or
glutaraldehyde
can
crosslink
hemoglobin
polyhemoglobin
(PolyHb)
prevent
its
breakdown
has
been
tested
trials.
A
bovine
approved
routine
surgical
procedures
South
Africa
Russia.
Clinical
trials
human
PolyHb
hemorrhagic
shock
were
effective
but
very
slight
increase
non-fatal
myocardial
ischemia.
could
be
due
to
number
reasons.
For
those
conditions
ischemia-reperfusion,
one
would
need
carrier
antioxidant
properties.
One
approach
remedy
this
prepared
polyhemoglobin-catalase-superoxide
dismutase
(PolyHb-CAT-SOD).
Another
reason
intracellular
pCO
2
.
We
therefore
added
enhanced
level
carbonic
prepare
PolyHb-CAT-SOD-CA.
result
Carbonic
Anhydrase
CO
transport
Catalase
Superoxide
Dismutase
functions.
Detailed
efficacy
safety
studies
have
led
industrial
scale
towards
trial.
In
meantime,
are
around
world
ex
vivo
fluid
organ
preservation
transplantation,
already
France.
European Heart Journal Supplements,
Journal Year:
2025,
Volume and Issue:
27(Supplement_4), P. iv31 - iv38
Published: Feb. 4, 2025
Abstract
Cardiac
arrest
is
a
critical
emergency
in
cardiovascular
medicine,
requiring
rapid,
multidisciplinary
interventions
to
enhance
patient
survival
and
neurological
outcomes.
This
review
explores
the
unique
challenges
of
managing
out-of-hospital
(OHCA)
in-hospital
cardiac
(IHCA),
with
focus
on
mechanical
circulatory
support
(MCS)
extracorporeal
cardiopulmonary
resuscitation
for
selected
patients.
While
OHCA
management
should
prioritize
rapid
transport
specialized
centres,
IHCA
may
allow
immediate,
patient-tailored
interventions.
Post-cardiac
syndrome
adds
complexity,
often
nuanced
MCS
escalation
weaning.
Standardized
protocols,
ethical
considerations,
further
research
are
essential
refine
selection
improve
outcomes,
ultimately
advancing
care.
Clinical Transplantation,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Feb. 1, 2025
The
demand
for
organ
transplantation
has
exceeded
the
global
supply
of
available
organs.
Donation
after
circulatory
death
(DCD)
is
considered
an
effective
method
to
solve
disparity
between
and
organs,
by
expanding
donor
pool.
However,
DCD
organs
experience
long-term
damage
caused
warm
ischemia
(WI)
microthrombosis
diffuse
intravascular
coagulation.
Unfortunately,
because
concerns
about
post-transplantation
complications,
most
high-risk
are
discarded,
resulting
in
wasted
medical
resources
economic
losses.
thrombolytic
therapy
before
may
dissolve
improve
microcirculation,
increase
use.
Herein,
we
review
current
status
potential
value
transplantation,
summarize
progress
according
preclinical
clinical
research,
emphasize
heterogeneity
limitations
studies
that
have
some
controversies
associated
with
this
therapy.
Overall,
role
should
not
be
overlooked.
We
anticipate
combined
machine
perfusion
will
provide
opportunity
inferior-quality
grafts,
their
becoming
more
widely
safer
thus
solving
urgent
problem
shortage.
Abstract
Managing
delivery
of
complex
multidrug
infusions
in
anesthesia
and
critical
care
presents
a
significant
clinical
challenge.
Current
practices
relying
on
manual
control
infusion
pumps
often
result
unpredictable
drug
profiles
dosing
errors—key
issues
highlighted
by
the
United
States
Food
Drug
Administration
(FDA).
To
address
these
issues,
we
introduce
SMART
(synchronized‐pump
management
algorithms
for
reliable
therapies)
framework,
novel
approach
that
leverages
low
Reynolds
number
transport
physics
machine
learning
to
accurately
manage
real‐time.
is
activated
based
Shafer
(),
non‐dimensional
quantifies
relative
magnitude
drug's
therapeutic
action
timescale
its
within
manifolds.
useful
when
,
where
becomes
rate
limiting
step
achieving
desired
effects.
When
activated,
monitors
concentrations
manifolds
this
information
perform
end‐to‐end
using
an
ensemble
deterministic
deep
reinforcement
(RL)
decision
networks.
Notably,
RL
networks
employ
differentially
sampled
split
buffer
architecture
accelerates
improves
performance
seamlessly
combining
predictions
with
experience
during
training.
deployed
standalone
under
simulated
conditions
outperformed
state‐of‐the‐art
protocols.
This
framework
has
potential
revolutionize
enhancing
accuracy
medication
reducing
cognitive
workloads.
Beyond
care,
ability
multi‐liquid
via
will
have
important
bearings
manufacturing
process
control.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(9), P. 3398 - 3417
Published: Jan. 1, 2023
Tracking
osmolyte
patterns
in
biological
contexts
can
help
design
novel
multicomponent
deep
eutectic
systems,
which
mimic
the
nuanced
microenvironment
of
biomacromolecules
operating
within
these
contexts.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
13(1), P. 56 - 56
Published: Dec. 21, 2023
Background:
Survival
following
cardiac
arrest
(CA)
remains
poor
after
conventional
cardiopulmonary
resuscitation
(CCPR)
(6–26%),
and
the
outcomes
extracorporeal
(ECPR)
are
often
inconsistent.
Poor
survival
is
a
consequence
of
CA,
low-flow
states
during
CCPR,
multi-organ
injury,
insufficient
monitoring,
delayed
treatment
causative
condition.
We
developed
new
strategy
to
address
these
issues.
Methods:
This
all-comers,
multicenter,
prospective
observational
study
(69
patients
with
in-
out-of-hospital
CA
(IHCA
OHCA)
prolonged
refractory
CCPR)
focused
on
support,
comprehensive
repair,
potential
for
cannulation
treatment.
Result:
The
overall
rate
at
hospital
discharge
was
42.0%,
favorable
neurological
outcome
(CPC
1+2)
90
days
achieved
79.3%
survivors
1+2
33%).
IHCA
very
(51.7%),
as
CPC
(41%).
OHCA
35%
28%.
subgroup
pre-hospital
showed
superior
57.1%.
Conclusions:
focusing
repairing
damage
multiple
organs
appears
improve
findings
should
provide
sound
basis
further
research
in
this
area.
