Shifting attention to orient or avoid: a unifying account of the tail of the striatum and its dopaminergic inputs

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 59, P. 101441 - 101441

Published: Sept. 2, 2024

The tail of the striatum (TS) is increasingly recognized as a unique subdivision striatum, characterized by its dense sensory inputs and projections received from distinct group dopamine neurons. Separate lines research have functional role TS, TS-projecting neurons, in three realms: saccadic eye movement towards valuable visual stimuli; tone-guided choice between two options; defensive responses to threatening stimuli. We propose framework for reconciling these diverse roles varied implementations conserved response salient stimuli, with TS providing teaching signal promote quick attentional shifts that facilitate stimulus-driven orientation and/or avoidance.

Language: Английский

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Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Some individuals are susceptible to chronic stress, and others more resilient. While many brain regions implicated in learning dysregulated after little is known about whether how neural teaching signals during stress differ between resilient individuals. Here, we seek determine if activity the lateral habenula (LHb), which encodes a negative signal, differs mice produce different outcomes. After (but not before) social defeat LHb active when proximity of aggressor strain. During higher interactions, activation biases toward susceptibility. This manipulation generates persistent widespread increase balance subcortical vs. cortical mice. Taken together, our results indicate that heightened produces lasting brainwide behavioral substrates

Language: Английский

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Pre-existing visual responses in a projection-defined dopamine population explain individual learning trajectories

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Learning a new task is challenging because the world high dimensional, with only subset of features being reward-relevant. What neural mechanisms contribute to initial acquisition, and why do some individuals learn much more quickly than others? To address these questions, we recorded longitudinally from dopamine (DA) axon terminals in mice learning visual task. Across striatum, DA responses tracked idiosyncratic side-specific trajectories. However, even before any rewards were delivered, contralateral-side-specific present dorsomedial striatum (DMS). These pre-existing predicted extent for contralateral stimuli. Moreover, activation improved performance. Thus, conditions projection-specific feature-specific signal help explain individual More broadly, this work implies that functional heterogeneity across projections serves bias target regions towards about different subsets features, providing mechanism dimensionality problem.

Language: Английский

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Ultrasound Stimulation Attenuates CRS-Induced Depressive Behavior by Modulating Dopamine Release in the Prefrontal Cortex

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 1314 - 1323

Published: Jan. 1, 2024

Depression is one of the most serious mental disorders affecting modern human life and often caused by chronic stress. Dopamine system dysfunction proposed to contribute pathophysiology stress, especially ventral tegmental area (VTA) which mainly consists dopaminergic neurons. Focused ultrasound stimulation (FUS) a promising neuromodulation modality multiple studies have demonstrated effective ultrasonic activation cortical, subcortical, related networks. However, effects FUS on dopamine potential link stress-induced depressive behaviors are relatively unknown. Here, we measured targeting VTA improvement depression-like behavior evaluated concentration in downstream region - medial prefrontal cortex (mPFC). We found that treatment alleviated restraint stress (CRS) -induced anhedonia despair behavior. Using an vivo photometry approach, analyzed signal mPFC revealed significant increase following FUS, positively associated with also protected neurons from damage CRS exposure. Thus, these results significantly rescued depressive-like declined level induced CRS. These beneficial might be due protection DA neuron VTA. Our findings suggest could serve as new therapeutic strategy for stress-related disorders.

Language: Английский

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Understanding the neural code of stress to control anhedonia

Nature, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Anhedonia, the diminished drive to seek, value, and learn about rewards, is a core feature of major depressive disorder 1–3 . The neural underpinnings anhedonia how this emotional state drives behaviour remain unclear. Here we investigated code by taking advantage fact that when mice are exposed traumatic social stress, susceptible animals become socially withdrawn anhedonic, whereas others resilient. By performing high-density electrophysiology record activity patterns in basolateral amygdala (BLA) ventral CA1 (vCA1), identified signatures susceptibility resilience. When actively sought BLA resilient showed robust discrimination between reward choices. contrast, exhibited rumination-like signature, which neurons encoded intention switch or stay on previously chosen reward. Manipulation vCA1 inputs rescued dysfunctional dynamics, amplified dynamics associated with resilience, reversed anhedonic behaviour. Finally, were at rest, spontaneous greater number distinct population states. This allowed us decode group identity infer whether mouse had history stress better than behavioural outcomes alone. work reveals population-level explain individual differences responses suggests modulating vCA1–BLA can enhance resilience regulating these dynamics.

Language: Английский

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