Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 19(4), P. 428 - 447
Published: Dec. 27, 2023
Language: Английский
Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2188 - 2205
Published: Oct. 1, 2023
The cancer-immunity cycle provides a framework to understand the series of events that generate anti-cancer immune responses. It emphasizes iterative nature response where killing tumor cells by T initiates subsequent rounds antigen presentation and cell stimulation, maintaining active immunity adapting it evolution. Any step can become rate-limiting, rendering system unable control growth. Here, we update based on remarkable progress past decade. Understanding mechanism checkpoint inhibition has evolved, as our view dendritic in sustaining anti-tumor immunity. We additionally account for role microenvironment facilitating, not just suppressing, response, discuss importance considering tumor's immunological phenotype, "immunotype". While these new insights add some complexity cycle, they also provide targets research therapeutic intervention.
Language: Английский
Citations
351
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: Dec. 13, 2023
With the development and regulatory approval of immune checkpoint inhibitors adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over past decades. Recently, therapeutic vaccines have shown promise by eliciting de novo T responses targeting tumor antigens, including tumor-associated antigens tumor-specific antigens. The objective was to amplify diversify intrinsic repertoire cells. However, complete realization these capabilities remains an ongoing pursuit. Therefore, we provide overview current landscape in this review. range antigen selection, delivery systems strategic nuances underlying effective presentation pioneered vaccine design. Furthermore, review addresses status clinical trials discusses their strategies, focusing on immunogenicity anti-tumor efficacy assessment. attempts toward developing not yielded breakthrough outcomes due significant challenges, microenvironment suppression, optimal candidate identification, response evaluation, manufacturing acceleration. field is poised overcome hurdles improve patient future acknowledging complexities persistently striving surmount inherent constraints.
Language: Английский
Citations
189
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: July 17, 2024
Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive remarkable transformation. Emerging fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, gene therapy. These cutting-edge not only afford personalized precise targeting, but also provide enhanced comfort potential to impede disease progression. Nonetheless, it is acknowledged that these strategies still harbour untapped for further advancement. Gaining understanding merits limitations holds promise offering novel perspectives clinical practice foundational research endeavours. In this review, we discussed different modalities, including drugs, peptide antibody cell therapy, It will detailed explanation each method, addressing their status development, challenges, solutions. The aim assist clinicians researchers in gaining deeper diverse options, enabling them carry out effective advance more efficiently.
Language: Английский
Citations
162
Immunity, Journal Year: 2023, Volume and Issue: 56(10), P. 2231 - 2253
Published: Oct. 1, 2023
Language: Английский
Citations
158
Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(11), P. 739 - 754
Published: Aug. 16, 2023
Language: Английский
Citations
133
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(1), P. 7 - 24
Published: Oct. 5, 2023
Language: Английский
Citations
128
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
125
Cancer Cell, Journal Year: 2024, Volume and Issue: 42(2), P. 180 - 197
Published: Feb. 1, 2024
The past decade has witnessed significant advances in the systemic treatment of advanced hepatocellular carcinoma (HCC). Nevertheless, newly developed strategies have not achieved universal success and HCC patients frequently exhibit therapeutic resistance to these therapies. Precision represents a paradigm shift cancer recent years. This approach utilizes unique molecular characteristics individual patient personalize modalities, aiming maximize efficacy while minimizing side effects. Although precision shown multiple types, its application remains infancy. In this review, we discuss key aspects HCC, including biomarkers, classifications, heterogeneity tumor microenvironment. We also propose future directions, ranging from revolutionizing current methodologies personalizing therapy through functional assays, which will accelerate next phase advancements area.
Language: Английский
Citations
118
Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)
Published: Aug. 17, 2023
Abstract Gene therapy holds great promise for treating a multitude of inherited and acquired diseases by delivering functional genes, comprising DNA or RNA, into targeted cells tissues to elicit manipulation gene expression. However, the clinical implementation remains substantially impeded lack safe efficient delivery vehicles. This review comprehensively outlines novel fastest-growing non-viral vectors, which include liposomes lipid nanoparticles (LNPs), highly branched poly(β-amino ester) (HPAE), single-chain cyclic polymer (SCKP), poly(amidoamine) (PAMAM) dendrimers, polyethyleneimine (PEI). Particularly, we discuss research progress, potential development directions, remaining challenges. Additionally, provide comprehensive overview currently approved therapeutics, as well ongoing trials. With advances in biomedicine, molecular biology, materials science, vectors play an ever-expanding noteworthy role therapy.
Language: Английский
Citations
104
Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(4), P. 294 - 311
Published: Feb. 29, 2024
Language: Английский
Citations
103