Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116074 - 116074
Published: Dec. 25, 2023
Hepatocellular
carcinoma
(HCC)
remains
a
major
global
health
burden,
and
sorafenib,
multi-kinase
inhibitor,
has
shown
effectiveness
in
the
treatment
of
HCC
is
considered
as
first-line
therapy
for
advanced
HCC.
However,
response
to
sorafenib
varies
among
patients,
development
drug
resistance
poses
prevalent
obstacle.
Ferroptosis,
newly
characterized
form
cell
death
featured
by
iron-dependent
lipid
peroxidation,
emerged
critical
player
reaction
The
induction
ferroptosis
been
augment
anticancer
benefits
sorafenib.
it
also
observed
contribute
resistance.
This
review
presents
comprehensive
thorough
analysis
that
elucidates
intricate
relationship
between
over
recent
years,
aiming
formulate
effective
therapeutic
approaches
liver
cancer.
Based
on
this
exploration,
we
propose
innovative
strategies
intended
overcome
via
targeted
modulation
ferroptosis.
Small,
Journal Year:
2023,
Volume and Issue:
19(49)
Published: Aug. 18, 2023
Abstract
Magnetic
iron
oxide
nanoparticles
(MIONs)
based
T
2
‐weighted
magnetic
resonance
imaging
(MRI)
contrast
agents
(CAs)
are
liver‐specific
with
good
biocompatibility,
but
have
been
withdrawn
from
the
market
and
replaced
Eovist
(Gd‐EOB‐DTPA)
due
to
their
inherent
limitations
(e.g.,
susceptibility
artifacts,
high
moment,
dark
signals,
long
processing
time
of
imaging,
waiting
for
patients
after
administration).
Without
disadvantages
Gd‐chelates
MIONs,
recently
emerging
exceedingly
small
MIONs
(ES‐MIONs)
(<5
nm)
promising
1
CAs
MRI.
However,
there
rare
review
articles
focusing
on
ES‐MIONs
Herein,
recent
progress
ES‐MIONs,
including
synthesis
methods
(the
current
basic
improved
methods),
surface
modifications
(artificial
polymers,
natural
zwitterions,
functional
protein),
‐MRI
visual
strategies
(structural
remodeling,
reversible
self‐assemblies,
metal
ions
doped,
/
dual
modes,
PET/MRI
strategy),
imaging‐guided
cancer
therapy
(chemotherapy,
gene
therapy,
ferroptosis
photothermal
photodymatic
radiotherapy,
immuotherapy,
sonodynamic
multimode
therapy),
is
summarized.
The
detailed
description
applications
in
this
anticipated
attract
extensive
interest
researchers
different
fields
promote
participation
establishment
nanoplatforms
tumor
theranostics.
Nature Structural & Molecular Biology,
Journal Year:
2023,
Volume and Issue:
30(11), P. 1806 - 1815
Published: Nov. 1, 2023
Ferroptosis,
marked
by
iron-dependent
lipid
peroxidation,
may
present
an
Achilles
heel
for
the
treatment
of
cancers.
Ferroptosis
suppressor
protein-1
(FSP1),
as
second
ferroptosis
mainstay,
efficiently
prevents
peroxidation
via
NAD(P)H-dependent
reduction
quinones.
Because
its
molecular
mechanisms
have
remained
obscure,
we
studied
numerous
FSP1
mutations
in
cancer
or
identified
untargeted
random
mutagenesis.
This
mutational
analysis
elucidates
FAD/NAD(P)H-binding
site
and
proton-transfer
function
FSP1,
which
emerged
to
be
evolutionarily
conserved
among
different
NADH
quinone
reductases.
Using
mutagenesis
screens,
uncover
mechanism
action
next-generation
inhibitors.
Our
studies
identify
binding
pocket
first
inhibitor,
iFSP1,
introduce
species-independent
targeting
NAD(P)H-binding
pocket.
Conclusively,
our
study
provides
new
insights
into
functions
enables
rational
design
inhibitors
cells.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(9)
Published: Sept. 22, 2023
Abstract
Kidney
diseases
remain
one
of
the
leading
causes
human
death
and
have
placed
a
heavy
burden
on
medical
system.
Regulated
cell
contributes
to
pathology
plethora
renal
diseases.
Recently,
with
in-depth
studies
into
kidney
death,
new
iron-dependent
modality,
known
as
ferroptosis,
has
been
identified
attracted
considerable
attention
among
researchers
in
pathogenesis
therapeutics
treat
them.
The
majority
suggest
that
ferroptosis
plays
an
important
role
pathologies
multiple
diseases,
such
acute
injury
(AKI),
chronic
disease,
carcinoma.
In
this
review,
we
summarize
recently
regulatory
molecular
mechanisms
discuss
pathways
action
various
describe
protective
effect
inhibitors
against
especially
AKI.
By
summarizing
prominent
roles
different
progress
made
studying
provide
directions
strategies
for
future
research
summary,
ferroptotic
factors
are
potential
targets
therapeutic
intervention
alleviate
targeting
them
may
lead
treatments
patients
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
170, P. 116074 - 116074
Published: Dec. 25, 2023
Hepatocellular
carcinoma
(HCC)
remains
a
major
global
health
burden,
and
sorafenib,
multi-kinase
inhibitor,
has
shown
effectiveness
in
the
treatment
of
HCC
is
considered
as
first-line
therapy
for
advanced
HCC.
However,
response
to
sorafenib
varies
among
patients,
development
drug
resistance
poses
prevalent
obstacle.
Ferroptosis,
newly
characterized
form
cell
death
featured
by
iron-dependent
lipid
peroxidation,
emerged
critical
player
reaction
The
induction
ferroptosis
been
augment
anticancer
benefits
sorafenib.
it
also
observed
contribute
resistance.
This
review
presents
comprehensive
thorough
analysis
that
elucidates
intricate
relationship
between
over
recent
years,
aiming
formulate
effective
therapeutic
approaches
liver
cancer.
Based
on
this
exploration,
we
propose
innovative
strategies
intended
overcome
via
targeted
modulation
ferroptosis.
