Neuroepigenetic Editing DOI
Peter J. Hamilton,

Carissa J. Lim,

Eric J. Nestler

et al.

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 129 - 152

Published: Jan. 1, 2024

Language: Английский

Functional genomics and systems biology in human neuroscience DOI
Geneviève Konopka, Aparna Bhaduri

Nature, Journal Year: 2023, Volume and Issue: 623(7986), P. 274 - 282

Published: Nov. 8, 2023

Language: Английский

Citations

5
Possible roles of deep cortical neurons and oligodendrocytes in the neural basis of human sociality DOI Creative Commons
Noriyoshi Usui

Anatomical Science International, Journal Year: 2023, Volume and Issue: 99(1), P. 34 - 47

Published: Nov. 27, 2023

Language: Английский

Citations

4
Human‐specific insights into candidate genes and boosted discoveries of novel loci illuminate roles of neuroglia in reading disorders DOI Creative Commons
Wenhua Wei, Shaowei Ma, Bo Fu

et al.

Genes Brain & Behavior, Journal Year: 2024, Volume and Issue: 23(3)

Published: May 16, 2024

Abstract Reading disorders (RD) are human‐specific neuropsychological conditions associated with decoding printed words and/or reading comprehension. So far only a handful of candidate genes segregated in families and 42 loci from genome‐wide association study (GWAS) have been identified that jointly provided little clues pathophysiology. Leveraging genomic information, we critically assessed the RD candidates for first time found substantial features within. The GWAS (i.e., population signals) were distinct familial counterparts more likely pleiotropic neuropsychiatric traits to harbor regulatory elements (HSREs). Candidate human cortical morphology indeed showed expression adult brain cortices, particularly neuroglia regulated by HSREs. Expression levels across developmental stages clear pattern uplifted early development crucial development. Following new insights cognitive traits, four novel sub‐significant associations FOXO3 , MAPT KMT2E HTT ) Semaphorin gene family functional priors SEMA3A SEMA3E SEMA5B ). These related neuronal plasticity disorders, mostly conserved had evident neuroglial cells. Our findings illuminated regulation—an emerging hotspot studying neurodevelopmental highlighted need improving phenotyping avoid jeopardizing future genetic studies RD.

Language: Английский

Citations

1
Single-cell sequencing of the substantia nigra reveals microglial activation in a model of MPTP DOI Creative Commons

Qing Liu,

Ziyu Liu,

Wenmeng Xie

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: June 17, 2024

Background N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin widely used to induce PD models, but the effect of MPTP on cells and genes has not been fully elucidated. Methods Single-nucleus RNA sequencing was performed in Substantia Nigra (SN) mice. UMAP analysis for dimensionality reduction visualization SN Known marker highly expressed each cluster were annotate most clusters. Specific Differentially Expressed Genes (DEGs) risk find MPTP-associated cells. GO, KEGG, PPI network, GSEA CellChat reveal cell type-specific functional alterations disruption cell-cell communication networks. Subset reconstruction pseudotime activation status cells, transcription factors with trajectory characterized. Results Initially, we observed specific DEGs enrichment microglia. Next, We obtained phenotype changes microglia found that IGF, AGRN PTN pathways reduced Finally, analyzed state revealed pro-inflammatory characterized by Nfe2l2 Runx1. Conclusion Our work function, signaling key

Language: Английский

Citations

1
Neuroepigenetic Editing DOI
Peter J. Hamilton,

Carissa J. Lim,

Eric J. Nestler

et al.

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 129 - 152

Published: Jan. 1, 2024

Language: Английский

Citations

1