Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 499 - 499
Published: March 27, 2025
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest.
Senescent
cells
(SCs)
accumulate
in
the
body
with
age
and
secrete
harmful
substances
known
as
senescence-associated
secretory
phenotype
(SASP),
causing
chronic
inflammation;
at
same
time,
inflammation
leads
to
a
decrease
immune
system
function,
immunosenescence,
which
further
accelerates
aging
process.
immunosenescence
are
closely
related
variety
diseases,
including
cardiovascular
metabolic
disorders,
autoimmune
neurodegenerative
diseases.
Studying
mechanisms
cellular
developing
targeted
interventions
crucial
for
improving
function
quality
life
elderly
people.
Here,
we
review
series
recent
studies
focusing
on
molecular
regulation
by
system,
latest
advances
basic
clinical
research
senolytics.
We
summarize
animal
models
research,
well
mechanisms,
strategies,
future
directions
from
immunological
perspective,
hope
laying
foundation
novel
practical
anti-aging
therapies.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Abstract
Sigal
peptides
have
garnered
remarkable
efficacy
in
rejuvenating
photoaged
skin
and
delaying
senescence.
Nevertheless,
their
low
solubility
poor
permeability
bring
about
a
formidable
challenge
transdermal
delivery.
To
address
this
challenge,
bioactive
ionic
liquids
(ILs)
synthesized
from
natural
glycyrrhizic
acid
(GA)
oxymatrine
(OMT)
with
eminent
biocompatibility
is
first
prepared.
The
components
ratios
inherent
forming
mechanisms
of
GA‐OMT
(GAO)
are
optimized
by
molecular
dynamics
simulations
density
functional
theory
calculations.
Remarkably,
GAO
can
significantly
improve
the
sparingly
soluble
properties
palmitoyl
pentapeptide‐4
(PAL‐4),
model
peptide
drug.
Subsequently,
self‐assembled
micelles
loading
PAL‐4
(GAO/PAL‐4‐SM)
fabricated
without
additional
auxiliary
materials.
permeation
subcutaneous
retention
promoted
10wt.%
GAO‐SM.
Moreover,
ILs
facilitated
enhancing
its
miscibility
interaction
stratum
corneum
(SC),
offering
pulling
effect
micellar
structures
for
PAL‐4,
as
elucidated
computational
simulations.
In
cellular
animal
photoaging
experiments,
GAO/PAL‐4‐SM
possessed
capabilities
boosting
collagen
hyaluronic
regeneration,
mitigating
inflammation
apoptosis,
accelerating
macrophage
M2
polarization,
thereby
lessening
wrinkles
leveraging
elasticity.
Collectively,
research
innovatively
designed
an
nano‐micellar
delivery
system
to
enhance
anti‐photoaging
signal
peptides.
Activation
of
the
subventricular
zone
(SVZ)
following
cerebral
ischemia
is
one
brain’s
early
responses
to
counteract
neuron
loss
and
minimize
tissue
damage.
Impaired
brain
regions
communicate
with
SVZ
through
various
chemotactic
signals
that
promote
cell
migration
differentiation,
primarily
involving
neural
stem
cells
(NSC),
neuroblasts,
or
glioblasts.
However,
activation
gliogenesis
role
newly
formed
astrocytes
in
post-ischemic
scenario
remain
subjects
debate.
We
have
previously
demonstrated
adenosine
release
after
prompts
generate
new
astrocytes.
Here,
we
used
transient
mice
identify
cellular
origin
these
within
neurogenic
niche
investigate
their
pathological
process.
By
combining
immunofluorescence,
BrdU-tracing,
genetic
labeling,
tracked
newborn
astrocytes,
positive
for
proteoglycan
marker
Thbs4,
from
dorsal
medial
perilesional
barrier
surrounding
ischemic
core,
known
as
“glial
scar”.
found
Thbs4-positive
modulate
dense
extracellular
matrix
at
lesion
border
by
both
synthesizing
degrading
hyaluronan.
also
show
while
accumulation
hyaluronan
site
sufficient
recruit
its
degradation
correlates
gliogenesis.
These
findings
suggest
could
be
a
promising
pharmacological
target
modulating
glial
scar
facilitate
regeneration.
Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 499 - 499
Published: March 27, 2025
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest.
Senescent
cells
(SCs)
accumulate
in
the
body
with
age
and
secrete
harmful
substances
known
as
senescence-associated
secretory
phenotype
(SASP),
causing
chronic
inflammation;
at
same
time,
inflammation
leads
to
a
decrease
immune
system
function,
immunosenescence,
which
further
accelerates
aging
process.
immunosenescence
are
closely
related
variety
diseases,
including
cardiovascular
metabolic
disorders,
autoimmune
neurodegenerative
diseases.
Studying
mechanisms
cellular
developing
targeted
interventions
crucial
for
improving
function
quality
life
elderly
people.
Here,
we
review
series
recent
studies
focusing
on
molecular
regulation
by
system,
latest
advances
basic
clinical
research
senolytics.
We
summarize
animal
models
research,
well
mechanisms,
strategies,
future
directions
from
immunological
perspective,
hope
laying
foundation
novel
practical
anti-aging
therapies.
