BMC Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Jan. 21, 2025
Cigarette
smoking
is
posited
as
a
potential
factor
in
disrupting
the
balance
of
human
gut
microbiota.
However,
existing
studies
with
limited
sample
size
have
yielded
inconclusive
results.
Here,
we
assessed
association
between
cigarette
and
microbial
profile
among
Chinese
males
from
four
independent
(N
total
=
3308).
Both
16S
rRNA
shotgun
metagenomic
sequencing
methods
were
employed,
covering
206
genera
237
species.
Microbial
diversity
abundance
compared
non-smokers,
current
smokers,
former
smokers.
Actinomyces[g],
Atopobium[g],
Haemophilus[g],
Turicibacter[g],
Lachnospira[g]
found
to
be
associated
status
(current
smokers
vs.
non-smokers).
Metagenomic
data
provided
higher
resolution
at
species
level,
particularly
for
Actinomyces[g]
branch.
Additionally,
serum
γ-glutamylcysteine
(γ-Glu-Cys)
was
role
connecting
Actinomyces[g].
Furthermore,
revealed
putative
mediation
roles
microbiome
associations
common
diseases
including
cholecystitis
type
2
diabetes.
We
characterized
microbiota
male
further
their
involvement
mediating
impact
on
health
outcomes.
These
findings
advance
our
understanding
intricate
microbiome.
Trends in Microbiology,
Journal Year:
2024,
Volume and Issue:
32(12), P. 1229 - 1240
Published: June 5, 2024
Recent
studies
of
dynamic
interactions
between
epigenetic
modifications
a
host
organism
and
the
composition
or
activity
its
associated
gut
microbiota
suggest
an
opportunity
for
to
shape
microbiome
through
alterations
that
lead
changes
in
gene
expression
noncoding
RNA
activity.
We
use
insights
from
microbiota-induced
review
potential
epigenetically
regulate
microbiome,
which
bidirectional
'epigenome–microbiome
axis'
emerges.
This
axis
embeds
environmentally
induced
variation,
may
influence
adaptive
evolution
host–microbe
interactions.
furthermore
present
our
perspective
on
how
epigenome–microbiome
can
be
understood
investigated
within
holo-omic
framework
with
applications
applied
health
food
sciences.
Cell Host & Microbe,
Journal Year:
2024,
Volume and Issue:
32(6), P. 820 - 836
Published: June 1, 2024
Microbial
communities
that
colonize
the
human
gastrointestinal
(GI)
tract
defend
against
pathogens
through
a
mechanism
known
as
colonization
resistance
(CR).
Advances
in
technologies
such
next-generation
sequencing,
gnotobiotic
mouse
models,
and
bacterial
cultivation
have
enhanced
our
understanding
of
underlying
mechanisms
intricate
microbial
interactions
involved
CR.
Rather
than
being
attributed
to
specific
clades,
CR
is
now
understood
arise
from
dynamic
interplay
between
microbes
host
shaped
by
metabolic,
immune,
environmental
factors.
This
evolving
perspective
underscores
significance
contextual
factors,
encompassing
microbiome
composition
conditions,
determining
review
highlights
recent
research
has
shifted
its
focus
toward
elucidating
how
these
factors
interact
either
promote
or
impede
enteric
infections.
It
further
discusses
future
directions
unravel
complex
relationship
host,
microbiota,
determinants
safeguarding
GI
infections
health.
Gut,
Journal Year:
2024,
Volume and Issue:
73(11), P. 1909 - 1920
Published: July 13, 2024
The
gut
microbiome
has
been
recognised
as
a
key
component
in
the
pathogenesis
of
inflammatory
bowel
diseases
(IBD),
and
wide
range
metabolites
produced
by
bacteria
are
an
important
mechanism
which
human
interacts
with
host
immunity
or
metabolism.
High-throughput
metabolomic
profiling
novel
computational
approaches
now
allow
for
comprehensive
assessment
thousands
diverse
biomaterials,
including
faecal
samples.
Several
groups
metabolites,
short-chain
fatty
acids,
tryptophan
bile
have
associated
IBD.
In
this
Seminars in Immunopathology,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: March 4, 2025
Abstract
Understanding
the
role
of
gut
microbiota
in
pathogenesis
inflammatory
bowel
diseases
(IBD)
has
been
an
area
intense
research
over
past
decades.
Patients
with
IBD
exhibit
alterations
their
microbial
composition
compared
to
healthy
controls.
However,
studies
focusing
solely
on
taxonomic
analyses
have
struggled
deliver
replicable
findings
across
cohorts
regarding
which
species
drive
distinct
patterns
IBD.
The
focus
therefore
shifted
studying
functionality
microbes,
especially
by
investigating
effector
molecules
involved
immunomodulatory
functions
microbiota,
namely
metabolites.
Metabolic
profiles
are
altered
IBD,
and
several
metabolites
shown
play
a
causative
shaping
immune
animal
models.
Therefore,
understanding
complex
communication
between
metabolites,
host
bears
great
potential
unlock
new
biomarkers
for
diagnosis,
disease
course
therapy
response
as
well
novel
therapeutic
options
treatment
In
this
review,
we
primarily
promising
classes
thought
exert
beneficial
effects
generally
decreased
Though
results
from
human
trials
promising,
they
not
so
far
provided
large-scale
break-through
IBD-therapy
improvement.
We
propose
tailored
personalized
supplementation
based
multi-omics
analysis
accounts
individual
metabolic
patients
rather
than
one-size-fits-all
approaches.
