Viral persistence in long COVID: Research advances and treatment strategies DOI Creative Commons
Shiyang Liu, Yuming Guo, Fu‐Sheng Wang

et al.

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Although the coronavirus disease 2019 (COVID-19) pandemic has ended, enduring health impacts of severe acute respiratory syndrome 2 (SARS-CoV-2) infection continue to garner global attention, as approximately 10% patients develop long COVID (post COVID-19 condition). The epidemiological characteristics and symptoms have been reported, various pathogenic hypotheses proposed. Recent evidence suggests that SARS-CoV-2 nucleic acids or fragments persist in some post-infection these are correlated with symptoms. This review focuses on clinical studies linking persistence symptoms, explores relationship between viral other etiological hypotheses, such immune dysregulation, vascular issues, coagulation dysfunction, microbiome dysbiosis, brainstem/vagus nerve signaling latent virus reactivation. Futhermore, treatment strategies for proposed based current trials antiviral modulation therapies. Understanding role pathogenesis is critical developing targeted therapies improving management this debilitating condition.

Language: Английский

Persistence and control of viruses on fomites and environmental matrices DOI
B. K. Olopade,

Md Faizur Rahman,

Mirza Mohammad Omar Khyum

et al.

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: April 21, 2025

Language: Английский

Citations

0
SARS-CoV-2 Spike Protein and Long COVID—Part 1: Impact of Spike Protein in Pathophysiological Mechanisms of Long COVID Syndrome DOI Creative Commons

Bruno Pereira de Melo,

João M. Silva,

Mariana Alves Rodrigues

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(5), P. 617 - 617

Published: April 25, 2025

SARS-CoV-2 infection has resulted in more than 700 million cases and nearly 7 deaths worldwide. Although vaccination efforts have effectively reduced mortality transmission rates, a significant proportion of recovered patients—up to 40%—develop long COVID syndrome (LC) or post-acute sequelae COVID-19 (PASC). LC is characterized by the persistence emergence new symptoms following initial infection, affecting cardiovascular, neurological, respiratory, gastrointestinal, reproductive, immune systems. Despite broad range clinical that been described, risk factors pathogenic mechanisms behind remain unclear. This review, first two-part series, distinguished discussion role spike protein primary underlying pathophysiology LC.

Language: Английский

Citations

0
Human close contact behavior based respiratory diseases transmission in a university office building DOI
Nan Zhang,

Palmira Elisa Nhantumbo,

Haochen Zhang

et al.

Microbial Risk Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 100344 - 100344

Published: April 1, 2025

Language: Английский

Citations

0
Variable rates of SARS-CoV-2 evolution in chronic infections DOI Creative Commons

Ewan W. Smith,

William L. Hamilton, Ben Warne

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(4), P. e1013109 - e1013109

Published: April 28, 2025

An important feature of the evolution SARS-CoV-2 virus has been emergence highly mutated novel variants, which are characterised by gain multiple mutations relative to viruses circulating in general global population. Cases chronic viral infection have suggested as an explanation for this phenomenon, whereby extended period infection, with increased rate evolution, creates substantial genetic novelty. However, measuring a during is made more difficult potential existence compartmentalisation population, host form distinct subpopulations. We here describe and apply statistical method study within-host identifying minimum number subpopulations required explain sequence data observed from cases inferring rates evolution. Across nine hospitalised patients we find that non-trivial population structure relatively common, five showing evidence than one evolving independently within host. The detection was common severely immunocompromised individuals (p = 0.04, Fisher’s Exact Test). proceeding significantly faster, slower, same statistically distinguishable Non-trivial associated high were systematically underestimated standard inference method.

Language: Английский

Citations

0
Viral persistence in long COVID: Research advances and treatment strategies DOI Creative Commons
Shiyang Liu, Yuming Guo, Fu‐Sheng Wang

et al.

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Although the coronavirus disease 2019 (COVID-19) pandemic has ended, enduring health impacts of severe acute respiratory syndrome 2 (SARS-CoV-2) infection continue to garner global attention, as approximately 10% patients develop long COVID (post COVID-19 condition). The epidemiological characteristics and symptoms have been reported, various pathogenic hypotheses proposed. Recent evidence suggests that SARS-CoV-2 nucleic acids or fragments persist in some post-infection these are correlated with symptoms. This review focuses on clinical studies linking persistence symptoms, explores relationship between viral other etiological hypotheses, such immune dysregulation, vascular issues, coagulation dysfunction, microbiome dysbiosis, brainstem/vagus nerve signaling latent virus reactivation. Futhermore, treatment strategies for proposed based current trials antiviral modulation therapies. Understanding role pathogenesis is critical developing targeted therapies improving management this debilitating condition.

Language: Английский

Citations

0