The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens DOI Creative Commons

Zhiwen Jiang,

Ziqing Yan,

Yali Hou

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1144 - D1150

Published: Dec. 6, 2024

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects remain unexplored, such their potential unconventional models, molecular underpinnings intriguing complex phenotypes, adaptations to environment or climate change, host-pathogen interactions arms race evolution. These challenges require a systematic framework integrate genomic variations among with information rodent-borne To address this gap, we have established comprehensive, freely accessible, user-friendly atlas named Rodent Genome Pathogen multi-Omics (RodentGPOmics), which provides comparative analysis rodent genomes zoonotic pathogen sequences rodents. The RodentGPOmics Atlas provides: (i) basic 2706 species; (ii) chromosome-level visualization genomes, functional annotations, comparisons across 121 (iii) epidemiological profiles based 21 852 reported (iv) few tools in-depth exploration multi-omics. This resource aims advance development models humans promoting public health, well innovate genetics, genomics, evolution rodents, offer valuable knowledge emerging/re-emerging infectious diseases. resources are available easy-to-use at http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage.

Language: Английский

Adaptations in surprising places DOI
Kimberly A. Rosvall

Science, Journal Year: 2025, Volume and Issue: 387(6732), P. 358 - 359

Published: Jan. 23, 2025

Testosterone is controlled while it circulates in the bloodstream

Language: Английский

Citations

0
Adrenocortical stem cells in health and disease DOI

Yulan Chu,

Jordan Setayesh, Typhanie Dumontet

et al.

Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Evolution of neural circuits in the origin of behavioral novelty DOI
Yun Ding

Current Opinion in Behavioral Sciences, Journal Year: 2025, Volume and Issue: 63, P. 101520 - 101520

Published: April 6, 2025

Language: Английский

Citations

0
Conservation, alteration, and redistribution of mammalian striatal interneurons DOI Creative Commons
Emily K. Corrigan, Michael DeBerardine, Aunoy Poddar

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute this variation remains unresolved. Recent studies suggest there is a primate-specific population of striatal inhibitory interneurons, TAC3 interneurons5. However, has not yet been detailed analysis spatial phylogenetic distribution population. Here, we profile single gene expression developing pig (an ungulate) ferret (a carnivore), representing 94 million years divergence from primates, assign newborn neurons initial classes first specified during development. We find that class interneurons represents an ancestral also deployed towards cortex ferret. In adult mouse, uncover rare expressing Tac2, ortholog TAC3, ventromedial striatum, prompting reexamination mouse interneuron by targeted enrichment their precursors. conclude conserved across Boreoeutherian mammals, with Th subset expresses Tac2. This study suggests telencephalic are largely evolution, neuronal mammalian brain change through redistribution fate refinement, rather than derivation precursors early

Language: Английский

Citations

3
The Neurobiology of Parenting and Infant-Evoked Aggression DOI
Harris S. Kaplan, Patricia M. Horvath, Mohammed Mostafizur Rahman

et al.

Physiological Reviews, Journal Year: 2024, Volume and Issue: 105(1), P. 315 - 381

Published: Aug. 15, 2024

Parenting behavior comprises a variety of adult-infant and adult-adult interactions across multiple timescales. The state transition from nonparent to parent requires an extensive reorganization individual priorities physiology is facilitated by combinatorial hormone action on specific cell types that are integrated throughout interconnected brainwide neuronal circuits. In this review, we take comprehensive approach integrate historical current literature each these topics species, with focus rodents. New emerging molecular, circuit-based, computational technologies have recently been used address outstanding gaps in our framework knowledge infant-directed behavior. This work raising fundamental questions about the interplay between instinctive learned components parenting mutual regulation affiliative versus agonistic behaviors health disease. Whenever possible, point how helped gain novel insights opened new avenues research into neurobiology parenting. We hope review will serve as introduction for those field, resource already studying parenting, guidepost designing future studies.

Language: Английский

Citations

1
Parental-care puzzle in mice solved by thinking outside the brain DOI
Jessica Tollkühn

Nature, Journal Year: 2024, Volume and Issue: 629(8014), P. 1006 - 1008

Published: May 15, 2024

Language: Английский

Citations

0
Non-classical animal models for studying adrenal diseases: advantages, limitations, and implications for research DOI Creative Commons

Alina Bilyalova,

Airat Bilyalov,

Nikita Filatov

et al.

Laboratory Animal Research, Journal Year: 2024, Volume and Issue: 40(1)

Published: June 19, 2024

Abstract The study of adrenal disorders is a key component scientific research, driven by the complex innervation, unique structure, and essential functions glands. This review explores use non-traditional animal models for studying congenital hyperplasia. It highlights advantages, limitations, relevance these models, including domestic ferrets, dogs, guinea pigs, golden hamsters, spiny mice. We provide detailed analysis histological steroidogenesis pathways, genetic characteristics models. morphological functional similarities between glands mice humans highlight their potential as an important avenue future research.

Language: Английский

Citations

0
Revisiting the specific and potentially independent role of the gonad in hormone regulation and reproductive behavior DOI
Victoria S. Farrar

Journal of Experimental Biology, Journal Year: 2024, Volume and Issue: 227(21)

Published: Nov. 1, 2024

ABSTRACT Gonadal sex steroid hormones are well-studied modulators of reproductive physiology and behavior. Recent behavioral endocrinology research has focused on how the brain dynamically responds to – may even produce steroids, but gonadal tissues that primarily release these receive much less attention as a potential mediator variation. This Commentary revisits mechanisms by which hypothalamic–pituitary–gonadal (HPG) axis can be modulated specifically at level. These include those allow gonad regulated independently HPG axis, such receptors for non-HPG hormones, neural inputs local production conventional ‘neuropeptides'. Here, I highlight studies examine variation in diverse taxa, with an emphasis recent transcriptomic work. then outline future work establish functional roles behavior evaluate responsiveness environmental cues. When integrated mechanisms, further investigation hormone regulation yield new insight into control evolution steroid-mediated traits, including

Language: Английский

Citations

0
The RodentGPOmics Atlas: a comprehensive database of rodent biology for genomes and pathogens DOI Creative Commons

Zhiwen Jiang,

Ziqing Yan,

Yali Hou

et al.

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 53(D1), P. D1144 - D1150

Published: Dec. 6, 2024

Rodents represent the most abundant order of mammals, exhibiting remarkable diversity in morphology, habitats, behaviors, and hosted pathogens. Significant attention is currently focused on rodents as experimental animals for biomedical research. However, numerous aspects remain unexplored, such their potential unconventional models, molecular underpinnings intriguing complex phenotypes, adaptations to environment or climate change, host-pathogen interactions arms race evolution. These challenges require a systematic framework integrate genomic variations among with information rodent-borne To address this gap, we have established comprehensive, freely accessible, user-friendly atlas named Rodent Genome Pathogen multi-Omics (RodentGPOmics), which provides comparative analysis rodent genomes zoonotic pathogen sequences rodents. The RodentGPOmics Atlas provides: (i) basic 2706 species; (ii) chromosome-level visualization genomes, functional annotations, comparisons across 121 (iii) epidemiological profiles based 21 852 reported (iv) few tools in-depth exploration multi-omics. This resource aims advance development models humans promoting public health, well innovate genetics, genomics, evolution rodents, offer valuable knowledge emerging/re-emerging infectious diseases. resources are available easy-to-use at http://RodentGPOmics.njau.edu.cn:8888/Rodent/index/homePage.

Language: Английский

Citations

0