Long-term studies provide unique insights into evolution

Nature, Journal Year: 2025, Volume and Issue: 639(8055), P. 589 - 601

Published: March 19, 2025

Language: Английский

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The Relationship Between Biological Noise and Its Application: Understanding System Failures and Suggesting a Method to Enhance Functionality Based on the Constrained Disorder Principle

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 349 - 349

Published: March 27, 2025

The Constrained Disorder Principle (CDP) offers a new framework for understanding how biological systems use and manage noise to maintain optimal functionality. This review explores the relationship between at various scales, including genetic, cellular, organ levels, its implications system malfunctions. According CDP, all require an range of function appropriately, disease states can arise when these levels are disrupted. presents evidence supporting this principle across different contexts, such as genetic variability, cellular behavior, brain functions, human aging, evolution, drug administration. For accurate clinical assessments, it is essential distinguish technical variability intrinsic variability. When adequately constrained, serves fundamental mechanism adaptation functioning rather than simply source disruption. These findings have important developing more effective therapeutic strategies systems’ dynamics. CDP-based second-generation artificial intelligence help regulate address improved outcomes in conditions by incorporating controlled randomness. Understanding patterns has significant diagnosis, treatment monitoring, development medical conditions.

Language: Английский

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Assessing the 'Small Population' Paradigm: The Effects of Stochasticity on Evolutionary Change and Population Growth in a Bird Metapopulation

Ecology Letters, Journal Year: 2025, Volume and Issue: 28(4)

Published: April 1, 2025

Habitat loss is leading to smaller fragmented populations, increasing their susceptibility stochasticity. Quantifying the effects of demographic and environmental stochasticity on population dynamics contribution selection versus drift phenotypic change essential assess potential consequences change. We examined how influenced growth body mass changes over 22 years in 11 insular house sparrow (Passer domesticus) populations. Environmental induced synchrony rates across populations while also causing substantial island-specific fluctuations. Additionally, led larger annual rate fluctuations Although heavier individuals generally had higher fitness, we detected non-directional evolutionary mass, driven by rather than selection. Our study provides a unique quantitative assessment 'small population' paradigm, highlighting importance theoretically analyses long-term individual-based data understand drivers evolution population's viability.

Language: Английский

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Drosophila melanogaster pigmentation demonstrates adaptive phenotypic parallelism over multiple spatiotemporal scales

Evolution Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Populations are capable of responding to environmental change over ecological timescales via adaptive tracking. However, the translation from patterns allele frequency rapid adaptation complex traits remains unresolved. We used abdominal pigmentation in Drosophila melanogaster as a model phenotype address nature, genetic architecture, and repeatability field. show that D. evolves highly parallel deterministic response shared variation across latitude season natural North American populations. then experimentally evolved replicate, genetically diverse fly populations field mesocosms remove any confounding effects demography and/or cryptic structure may drive wild populations; we rapidly responds, parallel, fewer than 15 generations. Thus, concordantly spatial temporal climatic axes. next examined whether phenotypic differentiation was associated with at loci established links variance found all scales, were pigmentation-related loci, sets genes identified each scale largely nonoverlapping. Therefore, our findings suggest evolution is distinct components polygenic architecture shifting axis produce redundant patterns.

Language: Английский

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Dominance reversal protects large-effect resistance polymorphisms in temporally varying environments

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

A central challenge in evolutionary biology is to uncover mechanisms maintaining functional genetic variation heterogeneous environments

Language: Английский

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