Adaptive decision-making by ants in response to past, imminent, and predicted adversity DOI Creative Commons
Yusuke Notomi, Shigeto Dobata, Tomoki Kazawa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

ABSTRACT Many animals exhibit innate behaviours, which are often interpreted as hard-wired, reflex-like responses, particularly in insects. Among these beacon-aiming—an approach towards dark areas or objects—is observed many animals; however, its functional significance remains unclear, and some ant species do not it. Here we show that one such species, Camponotus japonicus, the behaviour was triggered only under adverse substrate conditions, during crossing of liquid-covered surfaces, regardless locomotor patterns like walking swimming, mere presence water, when upside-down. Once initiated, beacon-aiming persists even normal demonstrated by ants transitioning from water-covered to dry substrates suitable for comfortable walking. This behavioural flexibility indicates is hard-wired but modulated internal states. Furthermore, changes states may serve adaptive decision-making, potentially allowing prepare future conditions. The isolated on a water-surrounded platform gradually established an attraction direction beacon before ultimately swimming These findings suggest regulated states, especially anxiety-like formed response past, imminent, predicted conditions ants.

Language: Английский

Dopamine ‘gas pedal’ and serotonin ‘brake’ team up to accelerate learning DOI

Angie Voyles Askham

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila DOI Open Access
Denise Weber, Katrin Vogt, Anton Miroschnikow

et al.

Published: April 14, 2025

Dopaminergic neurons (DANs) carry out multiple tasks in the brain, including transmission of information related to rewards and punishments across various animal species. They are responsible for evaluating sensory input, storing resulting associations as memory, continuously updating them based on their relevance reliability. Accurate comprehension dopaminergic system’s operation necessitates an understanding specific functions mediated by individual DANs. To this end, our research employs Drosophila larvae, which possess approximately 12,000 brains, only around 1% (approximately 120) DANs.The presynaptic projections mushroom body (MB) - a brain region pivotal associative olfactory learning insects limited eight larval neurons. These DANs further subdivided into two clusters: primary protocerebral anterior medial cluster (pPAM) comprises four cells, dorsolateral 1 (DL1) remaining cells. Our findings confirm previous that demonstrates pPAM innervating MB’s lobe encode gustatory sugar reward signal. Furthermore, we have identified DL1 DAN-c1, DAN-d1, DAN-f1, DAN-g1 each innervates distinct compartments MB peduncle, lateral appendix, vertical lobe. Optogenetic activation DAN-f1 alone suffices substitute punishment. optogenetic inhibition, calcium imaging results electron microscopy-based reconstruction all input circuits demonstrate DAN encodes different aspect punishment, with being central importance salt dependent teaching signal.To summarize, investigation has revealed existence cellular division labor among concerning (pPAM cluster) punishment signals (DL1 cluster). Individual but partially overlapping aspects The striking resemblance organizing principle its adult counterpart mammalian basal ganglion suggests there may be number efficient neural circuit solutions available address more complex cognitive challenges nature.

Language: Английский

Citations

0
Four Individually Identified Paired Dopamine Neurons Signal Taste Punishment in Larval Drosophila DOI Open Access
Denise Weber, Katrin Vogt, Anton Miroschnikow

et al.

Published: May 12, 2025

Abstract Dopaminergic neurons (DANs) carry out multiple tasks in the brain, including transmission of information related to rewards and punishments across various animal species. They are responsible for evaluating sensory input, storing resulting associations as memory, continuously updating them based on their relevance reliability. Accurate comprehension dopaminergic system’s operation necessitates an understanding specific functions mediated by individual DANs. To this end, our research employs Drosophila larvae, which possess approximately 12,000 brains, only around 1% (approximately 120) The presynaptic projections mushroom body (MB) - a brain region pivotal associative olfactory learning insects limited eight larval neurons. These DANs further subdivided into two clusters: primary protocerebral anterior medial cluster (pPAM) comprises four cells, dorsolateral 1 (DL1) remaining cells. Our findings confirm previous that demonstrates pPAM innervating MB’s lobe encode gustatory sugar reward signal. Furthermore, we have identified DL1 DAN-c1, DAN-d1, DAN-f1, DAN-g1 each innervates distinct compartments MB peduncle, lateral appendix, vertical lobe. Optogenetic activation DAN-f1 alone suffices substitute punishment. optogenetic inhibition, calcium imaging results electron microscopy-based reconstruction all input circuits demonstrate DAN encodes different aspect punishment, with being central importance salt dependent teaching summarize, investigation has revealed existence cellular division labor among concerning (pPAM cluster) punishment signals (DL1 cluster). Individual but partially overlapping aspects striking resemblance organizing principle its adult counterpart mammalian basal ganglion suggests there may be number efficient neural circuit solutions available address more complex cognitive challenges nature.

Language: Английский

Citations

0
Neuromodulatory processing in the bi-pathway brain architecture DOI Creative Commons
Funing Li, Changmei Zhang, Jiulin Du

et al.

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 93, P. 103055 - 103055

Published: May 23, 2025

Language: Английский

Citations

0
Nickel–Platinum Double-Atom Catalysts for Real-Time Dopamine Detection in Sweat and Potential Applications in Flexible Zinc–Air Batteries DOI
Xin Zeng, Yong Zhang,

Xuheng Li

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 4, 2025

Dopamine plays an important function in the neurological system, and its detection sweat has received interest due to noninvasive nature. However, low concentration of dopamine hampered development current wearable sensors. To address this issue, we devised a novel approach based on nickel-platinum double-atom catalysts (Ni/Pt DACs), which exhibit exceptional oxidation properties. This extends range (10 nM 750 μM) reduces limit 5.48 nM, covering physiological concentrations human sweat. Experimental results density functional theory (DFT) simulations show that doping with platinum single atoms lowers activation energy reaction rate-determining step (RDS), increasing catalytic efficiency Ni/Pt DACs for dopamine. Furthermore, using hydrophilicity-modified four-inlet microfluidic device volunteer skin, were able measure real time cellphones. We also conducted preliminary investigation into application potential flexible zinc-air batteries (ZABs), including DFT theoretical analysis. discovery not only increases technology sweat, but sheds fresh light use diatomic batteries.

Language: Английский

Citations

0
Behavioral neuroscience: Flexible integration on the fly DOI
Katrin Vogt

Current Biology, Journal Year: 2024, Volume and Issue: 34(23), P. R1175 - R1177

Published: Dec. 1, 2024

Language: Английский

Citations

0
Adaptive decision-making by ants in response to past, imminent, and predicted adversity DOI Creative Commons
Yusuke Notomi, Shigeto Dobata, Tomoki Kazawa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

ABSTRACT Many animals exhibit innate behaviours, which are often interpreted as hard-wired, reflex-like responses, particularly in insects. Among these beacon-aiming—an approach towards dark areas or objects—is observed many animals; however, its functional significance remains unclear, and some ant species do not it. Here we show that one such species, Camponotus japonicus, the behaviour was triggered only under adverse substrate conditions, during crossing of liquid-covered surfaces, regardless locomotor patterns like walking swimming, mere presence water, when upside-down. Once initiated, beacon-aiming persists even normal demonstrated by ants transitioning from water-covered to dry substrates suitable for comfortable walking. This behavioural flexibility indicates is hard-wired but modulated internal states. Furthermore, changes states may serve adaptive decision-making, potentially allowing prepare future conditions. The isolated on a water-surrounded platform gradually established an attraction direction beacon before ultimately swimming These findings suggest regulated states, especially anxiety-like formed response past, imminent, predicted conditions ants.

Language: Английский

Citations

0