Mechanisms of tandem duplication in the cancer genome DOI
Ralph Scully, Dominik Głodzik, Francesca Menghi

et al.

DNA repair, Journal Year: 2024, Volume and Issue: 145, P. 103802 - 103802

Published: Dec. 25, 2024

Language: Английский

The Interplay Between Chromatin Remodeling and DNA Double-strand Break Repair: Implications for Cancer Biology and Therapeutics DOI Creative Commons
Liu‐Jun He, Jaeyoung Moon,

Chenghui Cai

et al.

DNA repair, Journal Year: 2025, Volume and Issue: 146, P. 103811 - 103811

Published: Jan. 15, 2025

Proper chromatin remodeling is crucial for many cellular physiological processes, including the repair of DNA double-strand break (DSB). While mechanism DSB well understood, connection between and remains incompletely elucidated. In this review, we aim to highlight recent studies demonstrating close relationship repair. We summarize impact on chromatin, nucleosome arrangement, organization, dynamics, conversely, role architecture in regulating Additionally, also contribution complexes cancer biology through discuss their potential as therapeutic targets cancer.

Language: Английский

Citations

1
Prime Editing: Mechanistic Insights and DNA Repair Modulation DOI Creative Commons

Astrid Mentani,

Marcello Maresca, Anna Shiriaeva

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 277 - 277

Published: Feb. 13, 2025

Prime editing is a genome technique that allows precise modifications of cellular DNA without relying on donor templates. Recently, several different prime editor proteins have been published in the literature, single- or double-strand breaks. When occurs, undergoes one repair pathways, and these processes can be modulated with use inhibitors. Firstly, this review provides an overview mechanisms their modulation by known In addition, we summarize editors provide comprehensive associated mechanisms. Finally, discuss delivery safety aspects editing.

Language: Английский

Citations

1
Two-ended recombination at a Flp-nickase-broken replication fork DOI Creative Commons
Rajula Elango, Namrata M. Nilavar,

Andrew G. Li

et al.

Molecular Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

6
Deciphering the fate of replication-induced DNA double-strand breaks DOI
Cody M. Rogers, Patrick Sung

Molecular Cell, Journal Year: 2025, Volume and Issue: 85(1), P. 3 - 4

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms and regulation of DNA end resection in the maintenance of genome stability DOI
Raphaël Ceccaldi, Petr Ćejka

Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
One-ended and two-ended breaks at nickase-broken replication forks DOI
Ralph Scully, Johannes C. Walter,

André Nussenzweig

et al.

DNA repair, Journal Year: 2024, Volume and Issue: 144, P. 103783 - 103783

Published: Nov. 4, 2024

Language: Английский

Citations

2
Cell cycle regulation of polymerase theta mediated end-joining underlies its sensitivity to loss of BLM-DNA2 DOI Creative Commons
Connor P. McBrine, Ryan B. Jensen, Megan C. King

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract DNA double-strand breaks (DSBs) are predominantly resolved by the error-prone non-homologous end-joining (NHEJ) or high-fidelity homologous recombination (HR) repair pathways. NHEJ involves minimal end-processing and drives direct ligation of broken ends, while HR first requires a DSB resection step that degrades 5’ strands to generate 3’ ssDNA tails necessary for homology search. When fails, an alternative pathway involving polymerase theta can serve as backup mechanism annealing ligating microhomologies present in on either side resected DSB. Resection is early commits HR, therefore considered prerequisite TMEJ well. It has been proposed exonuclease EXO1 helicase/nuclease complex BLM-DNA2 have redundant roles resection, may both contribute TMEJ. Here, we use sensitive deep-sequencing approach identify outcomes at endogenous locus response genetic chemical perturbation machinery. While observe our findings highlight predominant role facilitating However, careful cell cycle analysis revealed BLM-DNA primarily contributes ensuring normal progression G2/M transition, required become activated. We propose rather than direct, mechanistic critical functions BLM DNA2 genome replication largely account their contribution efficient

Language: Английский

Citations

0
Mechanisms of tandem duplication in the cancer genome DOI
Ralph Scully, Dominik Głodzik, Francesca Menghi

et al.

DNA repair, Journal Year: 2024, Volume and Issue: 145, P. 103802 - 103802

Published: Dec. 25, 2024

Language: Английский

Citations

0