Differential temporal filtering in the fly optic lobe DOI Creative Commons
Alexander Borst

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Visual interneurons come in many different flavors, representing luminance changes at one location as ON or OFF signals with dynamics, ranging from purely sustained to sharply transient responses. While the functional relevance of this representation for subsequent computations like direction-selective motion detection is well understood, mechanisms by which these differences dynamics arise are unclear. Here, I study question fly optic lobe. Taking advantage known connectome simulate a network five adjacent optical columns each comprising 65 cell types. Each neuron modeled an electrically compact single compartment, conductance-based element that receives input other neurons within its column and neighboring according intra- inter-columnar connectivity matrix. The sign determined transmitter type presynaptic receptor on postsynaptic side. In addition, some given voltage-dependent conductances transcriptome. As free parameters, has output gain, applied all synapses, respectively. parameters adjusted such spatio-temporal receptive field properties 13 out simulated match experimentally ones closely possible. Despite fact have identical leak conductance membrane capacitance, procedure leads surprisingly good fit data, where specific respond transiently while others way changes. This critically depends presence H-current first-order interneurons, i.e., lamina cells L1 L2: turning off eliminates response nature leaving only responses examined interneurons. conclude diverse dynamic behavior columnar lobe starts created their intrinsic properties. predict eliminating hyperpolarization-activated current RNAi should strongly affect medulla and, consequently, also higher-order functions depending them direction-selectivity T4 T5 neurons. Author summary transient. computations, detection, mechanism using simulating biophysically plausible way. Adjusting gain subset (those experimental data exist) matches kinetics real counterparts, identify particular voltage-gated ion channel present being critical study, therefore, predicts circuit downstream elements destruct computation direction selectivity.

Language: Английский

From the fly connectome to exact ring attractor dynamics DOI Creative Commons

Tirthabir Biswas,

Angel Stanoev, Sandro Romani

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Abstract A cognitive compass enabling spatial navigation requires neural representation of heading direction (HD), yet the circuit architecture this remains unclear. While various network models have been proposed to explain HD systems, these rely on simplified architectures that are incompatible with empirical observations from connectomes. Here we construct a novel model for fruit fly system satisfies both connectome-derived architectural constraints and functional requirement continuous representation. We characterize an ensemble attractor networks where neurons providing local mutual excitation coupled inhibitory neurons. discover new mechanism emerges combining symmetric anti-symmetric activity patterns. Our analysis reveals three distinct realizations all match observed neuron but differ in their predictions activation Further, found deviations can be compensated by cell-type-specific rescaling synaptic weights, which could potentially achieved through neuromodulation. This framework extended incorporate complete central complex connectome reveal principles circuits representing other quantities, such as location, across insects vertebrates.

Language: Английский

Citations

0
NeuroMechFly v2: simulating embodied sensorimotor control in adult Drosophila DOI
Sibo Wang, Victor Alfred Stimpfling, Thomas Ka Chung Lam

et al.

Nature Methods, Journal Year: 2024, Volume and Issue: 21(12), P. 2353 - 2362

Published: Nov. 12, 2024

Language: Английский

Citations

0
Differential temporal filtering in the fly optic lobe DOI Creative Commons
Alexander Borst

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Visual interneurons come in many different flavors, representing luminance changes at one location as ON or OFF signals with dynamics, ranging from purely sustained to sharply transient responses. While the functional relevance of this representation for subsequent computations like direction-selective motion detection is well understood, mechanisms by which these differences dynamics arise are unclear. Here, I study question fly optic lobe. Taking advantage known connectome simulate a network five adjacent optical columns each comprising 65 cell types. Each neuron modeled an electrically compact single compartment, conductance-based element that receives input other neurons within its column and neighboring according intra- inter-columnar connectivity matrix. The sign determined transmitter type presynaptic receptor on postsynaptic side. In addition, some given voltage-dependent conductances transcriptome. As free parameters, has output gain, applied all synapses, respectively. parameters adjusted such spatio-temporal receptive field properties 13 out simulated match experimentally ones closely possible. Despite fact have identical leak conductance membrane capacitance, procedure leads surprisingly good fit data, where specific respond transiently while others way changes. This critically depends presence H-current first-order interneurons, i.e., lamina cells L1 L2: turning off eliminates response nature leaving only responses examined interneurons. conclude diverse dynamic behavior columnar lobe starts created their intrinsic properties. predict eliminating hyperpolarization-activated current RNAi should strongly affect medulla and, consequently, also higher-order functions depending them direction-selectivity T4 T5 neurons. Author summary transient. computations, detection, mechanism using simulating biophysically plausible way. Adjusting gain subset (those experimental data exist) matches kinetics real counterparts, identify particular voltage-gated ion channel present being critical study, therefore, predicts circuit downstream elements destruct computation direction selectivity.

Language: Английский

Citations

0