The Oviposition Inhibitory Neuron is a potential hub of multi-circuit integration in the Drosophila brain DOI Open Access

Rhessa Weber Langstaff,

Pranjal Srivastava, Alexander B. Kunin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Abstract Understanding how neural circuits integrate sensory and state information to support context-dependent behavior is a central issue in neuroscience. In Drosophila, oviposition complex process which the fly integrates context choose an optimal location lay her eggs. The circuit that controls sequence known, but multiple modalities internal states not. We investigated circuitry underlying high-level processing related using Hemibrain connectome. identified Oviposition Inhibitory Neuron (oviIN) as key hub analyzed its inputs uncover potential parallel pathways may be responsible for computations decision-making. applied graph-theoretic analyses on sub-connectome of oviIN identify modules neurons constitute novel circuits. Our findings indicate form from unstructured neuropils Superior Protocerebrum where have been known occur.

Language: Английский

The role of fruitless in specifying courtship behaviors across divergent Drosophila species DOI Creative Commons
Christa A. Baker, Xiao-Juan Guan, Minseung Choi

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(11)

Published: March 13, 2024

Sex-specific behaviors are critical for reproduction and species survival. The sex-specifically spliced transcription factor

Language: Английский

Citations

6
Genetic, developmental, and neural changes underlying the evolution of butterfly mate preference DOI Creative Commons
Nicholas W. VanKuren, Nathan P. Buerkle, Wei Lu

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(3), P. e3002989 - e3002989

Published: March 11, 2025

Many studies have linked genetic variation to behavior, but few connect the intervening neural circuits that underlie arc from sensation action. Here, we used a combination of genome-wide association (GWA), developmental gene expression, and photoreceptor electrophysiology investigate architecture mate choice behavior in Heliconius cydno butterflies, clade where males identify preferred mates based on wing color patterns. We first found GWA variants most strongly associated with male were tightly controlling K locus, consistent previous mapping efforts. RNA-seq across time points then showed seven genes near top peaks differentially expressed eyes, optic lobes, or central brain white yellow H. males, many which known functions development maintenance synaptic connections. In visual system these identified striking physiological difference between could provide an evolutionarily labile circuit motif eye rapidly switch behavioral preference. Using single-cell recordings, some ultraviolet (UV)-sensitive photoreceptors receive inhibition long-wavelength eye. Surprisingly, proportion inhibited UV was correlated color, suggesting early stages processing plausibly influence courtship decisions. discuss potential links candidate this signature, suggest future avenues for experimental work. Taken together, our results support idea alterations peripheral nervous system, driven by expression differences, can significantly alter essential behaviors.

Language: Английский

Citations

0
Evolution of neural circuits in the origin of behavioral novelty DOI
Yun Ding

Current Opinion in Behavioral Sciences, Journal Year: 2025, Volume and Issue: 63, P. 101520 - 101520

Published: April 6, 2025

Language: Английский

Citations

0
Olfactory projection neuron rewiring in the brain of an ecological specialist DOI

Benedikt R Dürr,

Enrico Bertolini, S. Takagi

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115615 - 115615

Published: April 25, 2025

Language: Английский

Citations

0
Comparative connectomics of Drosophila descending and ascending neurons DOI Creative Commons
Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical an information bottleneck connecting brain ventral cord (an analogue spinal cord) comprises diverse populations descending neurons (DNs), ascending (ANs) sensory neurons, are crucial sensorimotor signalling control. Here, by integrating three separate electron microscopy (EM) datasets1-4, we provide complete connectomic description ANs DNs Drosophila female system compare them with male cord. Proofread neuronal reconstructions matched across hemispheres, datasets sexes. Crucially, also match 51% DN cell types to light-level data5 defining specific driver lines, as well classifying all populations. We use these results reveal circuit logic neurons. observe connected chains spanning neck, may subserve sequences. sexually dimorphic AN populations, detailed analyses selected circuits reproductive behaviours, including courtship6 (DNa12; known aSP22) song production7 (AN from hemilineage 08B) ovipositor extrusion8 (DNp13). Our work provides EM-level that span entire central adult animal.

Language: Английский

Citations

0
The Oviposition Inhibitory Neuron is a potential hub of multi-circuit integration in the Drosophila brain DOI Open Access

Rhessa Weber Langstaff,

Pranjal Srivastava, Alexander B. Kunin

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Abstract Understanding how neural circuits integrate sensory and state information to support context-dependent behavior is a central issue in neuroscience. In Drosophila, oviposition complex process which the fly integrates context choose an optimal location lay her eggs. The circuit that controls sequence known, but multiple modalities internal states not. We investigated circuitry underlying high-level processing related using Hemibrain connectome. identified Oviposition Inhibitory Neuron (oviIN) as key hub analyzed its inputs uncover potential parallel pathways may be responsible for computations decision-making. applied graph-theoretic analyses on sub-connectome of oviIN identify modules neurons constitute novel circuits. Our findings indicate form from unstructured neuropils Superior Protocerebrum where have been known occur.

Language: Английский

Citations

0