Mechanism of polyphenol-pea starch complexes on reducing fat accumulation in Caenorhabditis elegans

Food Research International, Journal Year: 2025, Volume and Issue: unknown, P. 116308 - 116308

Published: March 1, 2025

Language: Английский

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Platelet-Activating Factor-Induced Inflammation in Obesity: A Two-Sided Coin of Protection and Risk

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 471 - 471

Published: March 21, 2025

Obesity, marked by excessive fat accumulation, especially abdominal, is a global health concern with significant public impact. While obesity-associated chronic unresolved inflammation contributes to metabolic dysfunctions, acute supports healthy adipose tissue remodeling and expansion. Platelet-activating factor (PAF), “primitive” signaling molecule, among the key mediators involved in phase of various pathophysiological processes. This article explores role PAF accumulation obesity reviewing experimental data from cell cultures, animals, humans. It proposes an emerging biochemical mechanism attempt explain its dual obese tissue, including also on PAF’s potential involvement epigenetic mechanisms that may be linked “obesity memory”. Finally, it highlights natural modulators promoting functional thermogenesis, prevention through lifestyle, Mediterranean diet rich weak agonists/PAF receptor antagonists regular exercise, which help maintain controlled levels. Conversely, cases obesity-related systemic levels, potent inhibitors like ginkgolide B rupatadine mitigate dysfunctions PAFR potentially enhancing their effects synergistically.

Language: Английский

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Prescribing preoperative weight loss prior to major non-bariatric surgery for patients with elevated weight: a national provider survey (PREPARE provider survey)

Frontiers in Surgery, Journal Year: 2025, Volume and Issue: 12

Published: March 28, 2025

The surgical patient with obesity presents several challenges in intraoperative and postoperative care. We designed this cross-sectional survey to assess surgeon willingness prescribe preoperative very low energy diets (VLEDs) practice patterns prescribing weight loss interventions for patients undergoing non-bariatric abdominal surgery. conducted a of practicing surgeons Canada who perform major surgery, reported accordance the Consensus-Based Checklist Reporting Survey Studies utilizing non-probability convenience sampling. primary outcome was VLED obese surgery both benign malignant indications. created multivariable proportional odds model identify factors associated VLEDs. A total 78 participants completed returned (response rate 10.9%; mean age 43.54 ± 8.13 years; 48.72% female). Most (79.5%) felt that significantly impacted technical difficulty their operations. identified disconnect between those were willing VLEDs vs. actually prescribed them (78.2% 30.8%, respectively). Approximately half being unfamiliar Regression analysis academic institutions increased [odds ratio (OR) 3.71, 95% confidence intervals (CI) 1.01-13.7, p < 0.01]. Although majority feel adversely impacts perioperative care, only one-third routinely discuss patients. Opportunities increase awareness evaluate impact on outcomes remain high.

Language: Английский

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Physiology of Weight Regain after Weight Loss: Latest Insights

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: March 31, 2025

Language: Английский

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Chronicity of obesity and the importance of early treatment to reduce cardiometabolic risk and improve body composition

Obesity Pillars, Journal Year: 2025, Volume and Issue: unknown, P. 100175 - 100175

Published: April 1, 2025

Language: Английский

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