Nature, Journal Year: 2024, Volume and Issue: 636(8043), P. 581 - 583
Published: Nov. 27, 2024
Language: Английский
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Abstract Autism is a heterogeneous condition, and functional magnetic resonance imaging-based studies have advanced understanding of neurobiological correlates autistic features. Nevertheless, little work has focused on the optimal brain states to reveal brain-phenotype relationships. In addition, there need better understand relevance attentional abilities in mediating Using connectome-based predictive modelling, we interrogate three datasets determine scanning conditions that can boost prediction clinically relevant phenotypes assess generalizability. dataset one, sample youth with autism neurotypical participants, find sustained attention task (the gradual onset continuous performance task) results high traits compared free-viewing social resting-state condition. two, observe network model generated from generalizes predict measures adults. three, show same one further responsiveness data Brain Imaging Data Exchange. sum, our suggest an in-scanner challenge help delineate robust markers support continued investigation under which psychiatric conditions.
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 26, 2025
Major mental disorders are increasingly understood as of brain development. Large and heterogeneous samples required to define generalizable links between development psychopathology. To this end, we introduce the Reproducible Brain Charts (RBC), an open data resource that integrates from 5 large studies in youth three continents ( N =6,346; 45% Female). Confirmatory bifactor models were used create harmonized psychiatric phenotypes capture major dimensions Following rigorous quality assurance, neuroimaging carefully curated processed using consistent pipelines a reproducible manner with DataLad, Configurable Pipeline for Analysis Connectomes (C-PAC), FreeSurfer. Initial analyses RBC emphasize benefit careful assurance harmonization delineating developmental effects associations Critically, all - including phenotypes, unprocessed images, fully imaging derivatives openly shared without use agreement via International Neuroimaging Data-sharing Initiative. Together, facilitates large-scale, reproducible, research neuroscience.
Language: Английский
Citations
0
Journal of Neurodevelopmental Disorders, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 19, 2025
Abstract Background The Autonomic Nervous System (ANS) regulates ‘automatic’ functions such as heart rate, and alterations may have significant impacts on health outcomes. Cardiovascular measures of autonomic function rate variability are interest biological markers in autism spectrum disorder (ASD). interplay between the ANS physical establishes a need to examine cardiovascular functioning youth with without ASD over development. current study aimed identify change balance across parasympathetic sympathetic branches time diagnosis, age, pubertal development, status. Methods included 244 ( N = 140) or neurotypical (NT) 104) youth, ages 10 13 years at enrollment followed four years. Resting state was measured using respiratory sinus arrhythmia (RSA; parasympathetic) pre-ejection period (PEP; sympathetic). regulation were also examined Linear mixed models tested between- within-group differences primary outcomes well influence body weight, medication use. Results Baseline showed diagnostic differences, lower regulation, ASD, but no observed for other three Adding mass index (BMI) percentile use removed statistically effect, while both variables significantly related RSA overall regulation. Parasympathetic (RSA) stable age stage, notable decrease control (increased PEP) found stage. BMI predicted function, did not. Conclusions Minimal research date has explored (e.g., BMI) ASD. few group yet demonstrates important effects youth. Findings further emphasize focus individual traits elucidate extent which status, irrespective category, lifespan.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
The majority of neuroimaging inference focuses on hypothesis testing rather than effect estimation. With concerns about replicability, there is growing interest in reporting standardized sizes from group-level analyses. Confidence sets are a recently developed approach to perform for but restricted univariate and cross-sectional data. Thus, existing methods exclude increasingly common multigroup or nonlinear longitudinal associations biological brain measurements with inter- intra-individual variations diagnosis, development, symptoms. We broadly generalize the confidence set by developing method arbitrary studies. Our involves robust estimation size image spatial temporal covariance function based generalized estimating equations. obtain more efficient estimates concurrently exchangeable working using nonparametric bootstrap determine joint distribution across voxels used construct sets. These identify regions where lower upper simultaneous interval above below given threshold high probability. evaluate coverage width proposed procedures realistic simulations analyses aging diagnostic differences cortical thickness Alzheimer's disease resting-state hippocampal activity psychosis. This comprehensive along visualization functions integrated into pbj R package offers tool analyzing repeated measurements.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 3, 2025
The blood-brain barrier (BBB) presents a formidable challenge in neuropharmacology, limiting the delivery of therapeutic agents to brain. Exosomes, nature's nanocarriers, have emerged as promising solution due their biocompatibility, low immunogenicity, and innate ability traverse BBB. A thorough examination BBB anatomy physiology reveals complexities neurological drug underscores limitations conventional methods. This review explores potential exosome-powered neuropharmaceutics, highlighting structural functional properties, biogenesis, mechanisms release. Their intrinsic advantages delivery, including enhanced stability efficient cellular uptake, are discussed detail. Exosomes naturally overcome barriers through specific translocation mechanisms, making them compelling vehicle for targeted brain therapies. Advances engineering strategies, such genetic biochemical modifications, loading techniques, specificity enhancement, further bolster potential. Exosome-based approaches hold immense promise treating spectrum disorders, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), multiple (MS), tumors, stroke, psychiatric conditions. By leveraging properties innovations, exosomes offer versatile platform precision neurotherapeutics. Despite promise, challenges remain clinical translation, large-scale production, standardization, regulatory considerations. Future research directions exosome nanobiotechnology aim refine these unlocking new avenues diseases. transformative impact exosome-based paving way next-generation therapies that can effectively penetrate revolutionize neuropharmacology.
Language: Английский
Citations
0
Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 26, P. e56573 - e56573
Published: Dec. 9, 2024
Bariatric surgery is an effective intervention for obesity, but comprehensive postoperative self-management essential optimal outcomes. While patient portals are generally seen as beneficial in engaging patients health management, the link between their use and post-bariatric weight loss remains unclear.
Language: Английский
Citations
1
Nature, Journal Year: 2024, Volume and Issue: 636(8043), P. 581 - 583
Published: Nov. 27, 2024
Language: Английский
Citations
0