Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice DOI Creative Commons
Yukiko Harima, Masafumi Tsurutani, S. Yamada

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 10, 2024

The sympathetic nervous system is crucial for responding to environmental changes. This regulation coordinated by the spinal preganglionic neurons (SPNs), innervating both postganglionic and adrenal gland. Despite decades of research supporting concept selective control within this system, neural circuit organization responsible output specificity remains poorly understood. Here, combining recent single-cell transcriptome data with viral-genetic toolkits in mice, we identify two subtypes SPNs lower thoracic cord, defined at molecular level, exhibiting nonoverlapping patterns innervation: one specifically projecting celiac/superior mesenteric ganglia, other targeting grand. Chemogenetic manipulations on these distinct SPN revealed impacts motility gastrointestinal tracts or glucose metabolism mediated gland, respectively. molecularly delineated parallel labeled-line outflows presents a potential avenue selectively manipulating organ functions.

Language: Английский

Sympathetic nerve activity in obesity-associated insulin resistance DOI Creative Commons
Shuting Xia,

Huili Wu,

Jianping Ye

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Deciphering the skeletal interoceptive circuitry to control bone homeostasis DOI Creative Commons

Yefeng Wu,

Jiusi Guo, Zhen Chen

et al.

BMEMat, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Bone tissue is richly innervated, and the influence of nervous system on physiological pathological status bone has emerged as a significant research focus. The recent discovery skeletal interoceptive circuits further emphasizes crucial role central in control homeostasis. Skeletal interoception represents one most intricate mechanisms human body for maintaining homeostasis, it involves orchestrated efforts skeletal, nervous, immune, endocrine systems. In this review, we comprehensively introduce three primary components circuitry, including ascending pathways that perceive convey signals to system, neural process interpret these signals, descending mediate regulatory effects tissue. We also discuss how innovative therapeutic strategies can be developed modulate homeostasis by leveraging updated findings circuitry. anticipate application knowledge will lead paradigm shift field orthopaedics biomaterials.

Language: Английский

Citations

0
The innervated gut and critical illness DOI

Jacob W. Larsson,

Peder S. Olofsson, Eva Sundman

et al.

Current Opinion in Critical Care, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

This review highlights brain-gut neuroimmune interactions in the context of critical illness. Neural regulation inflammation, gut innervation, and axis illness are discussed. Recent studies indicate that enteric nervous system integral to local systemic inflammation. Experimental evidence suggests neural reflexes control immune responses, specific signals promote gastrointestinal homeostasis. The understanding these clinical remains limited, necessitating further investigation. Notably, therapeutic interventions targeting neuro-immune pathways have shown promise preclinical models, suggesting a better crosstalk critically ill may potentially identify novel targets. Critical involves complex organ dysfunction, not least system. A multitude between intestinal wall, cells, peripheral nerves central regulate While experimental supports role controlling validation is lacking care. Future research needs explore whether or mechanisms can be harnessed restore support homeostasis ill.

Language: Английский

Citations

0
Gaskell, Langley, and the "para-sympathetic" idea DOI Creative Commons
Jean‐François Brunet

eLife, Journal Year: 2025, Volume and Issue: 14

Published: March 14, 2025

Historically, the creation of parasympathetic division autonomic nervous system vertebrates is inextricably linked to unification cranial and sacral outflows. There an intriguing disproportion between entrenchment notion a 'cranio-sacral' pathway, which informs every textbook schematic since early XXth century, wobbliness its two roots: anatomical detail overinterpreted by Walter Holbrook Gaskell (the 'gap' lumbar outflows), on John Newport Langley grafted piece physiology (a supposed antagonism these outflows external genitals), repeatedly questioned since, little avail. I retrace birth flawed scientific concept cranio-sacral outflow) way in it ossified instead dissipated. Then, suggest that critique 'cranio-sacral outflow' invites, turn, radical deconstruction very 'parasympathetic' outflow, more realistic description system.

Language: Английский

Citations

0
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice DOI Creative Commons
Yukiko Harima, Masafumi Tsurutani, S. Yamada

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 10, 2024

The sympathetic nervous system is crucial for responding to environmental changes. This regulation coordinated by the spinal preganglionic neurons (SPNs), innervating both postganglionic and adrenal gland. Despite decades of research supporting concept selective control within this system, neural circuit organization responsible output specificity remains poorly understood. Here, combining recent single-cell transcriptome data with viral-genetic toolkits in mice, we identify two subtypes SPNs lower thoracic cord, defined at molecular level, exhibiting nonoverlapping patterns innervation: one specifically projecting celiac/superior mesenteric ganglia, other targeting grand. Chemogenetic manipulations on these distinct SPN revealed impacts motility gastrointestinal tracts or glucose metabolism mediated gland, respectively. molecularly delineated parallel labeled-line outflows presents a potential avenue selectively manipulating organ functions.

Language: Английский

Citations

1