Spatio-temporal organization of network activity patterns in the hippocampus DOI Creative Commons
Vítor Lopes‐dos‐Santos, Demi Brizee, David Dupret

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(6), P. 115808 - 115808

Published: June 1, 2025

Understanding how coordinated neural networks support brain functions remains a central goal in neuroscience. The hippocampus, with its layered architecture and structured inputs to diverse cell populations, is tractable model for dissecting operating microcircuits through the analysis of electrophysiological signatures. We investigated hippocampal network patterns behaving mice by developing low-dimensional embedding local field potentials recorded along CA1-to-dentate gyrus axis. This revealed layer-specific gamma profiles reflecting spatially organized rhythms their associated principal cell-interneuron firing motifs. Moreover, behaviors CA1 radial axis distinguished between deep superficial cells, as well interneurons from pyramidal, radiatum, lacunosum-moleculare layers. These findings provide comprehensive map spatiotemporal activity underlying functions.

Language: Английский

Why don’t new memories overwrite old ones? Sleep science holds clues DOI

Traci Watson

Nature, Journal Year: 2025, Volume and Issue: 637(8046), P. 524 - 525

Published: Jan. 3, 2025

Language: Английский

Citations

0
Hippocampal Ripple Diversity organises Neuronal Reactivation Dynamics in the Offline Brain DOI Creative Commons
Manfredi Castelli, Vítor Lopes‐dos‐Santos, Giuseppe P. Gava

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Summary Hippocampal ripples are highly synchronized neuronal population patterns reactivating past waking experiences in the offline brain. Whether level, structure, and content of ripple-nested activity consistent across consecutive events or tuned each event remains unclear. By profiling individual using laminar currents mouse hippocampus during sleep/rest, we identified Rad sink LM featuring current sinks stratum radiatum versus lacunosum-moleculare , respectively. These two ripple profiles recruit neurons differently. integrate recent motifs coactivity, combining superficial deep CA1 principal cells into denser, higher-dimensional that undergo hour-long stable reactivation. In contrast, contain core prior engaging sparser, lower-dimensional a reactivation drift, gradually updating their pre-structured for wakefulness. We propose ripple-by-ripple diversity instantiates parallel channels integration wakefulness flexible internal representations.

Language: Английский

Citations

0
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation DOI
Ziru Deng, Xiang Fei, Siyu Zhang

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Monoaminergic signaling during mammalian NREM sleep - Recent insights and next-level questions DOI Creative Commons
Georgios Foustoukos, Georgios Foustoukos

Current Opinion in Neurobiology, Journal Year: 2025, Volume and Issue: 92, P. 103025 - 103025

Published: April 22, 2025

Language: Английский

Citations

0
The Eyes are The Windows To The Soul: Pupillary Changes Reflect The Consolidation of New and Old Memories During Sleep DOI

Wei-Kun Su,

Yan‐Jia Luo, Fangyuan Li

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Language: Английский

Citations

0
Local inhibitory circuits mediate cortical reactivations and memory consolidation DOI Creative Commons
Kristian Kinden Lensjø, Ingeborg Nymoen,

Frederik Sebastian Rogge

et al.

Science Advances, Journal Year: 2025, Volume and Issue: 11(22)

Published: May 30, 2025

Highly salient events activate neurons across various brain regions. During subsequent rest or sleep, the activity patterns of these often correlate with those observed during preceding experience. Growing evidence suggests that reactivations play a crucial role in memory consolidation, process by which experiences are solidified cortical networks for long-term storage. Here, we use longitudinal two-photon Ca 2+ imaging alongside paired LFP recordings hippocampus and cortex, to show targeted manipulation PV + inhibitory lateral visual cortex after daily training selectively attenuates cue-specific learning, only minute effects on spontaneous no apparent effect normal function such as cue–elicited responses training. In control mice, were biased toward cues, persisted hours had ended, prevalence was aligned learning process. Overall, our results underscore consolidation.

Language: Английский

Citations

0
Spatio-temporal organization of network activity patterns in the hippocampus DOI Creative Commons
Vítor Lopes‐dos‐Santos, Demi Brizee, David Dupret

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(6), P. 115808 - 115808

Published: June 1, 2025

Understanding how coordinated neural networks support brain functions remains a central goal in neuroscience. The hippocampus, with its layered architecture and structured inputs to diverse cell populations, is tractable model for dissecting operating microcircuits through the analysis of electrophysiological signatures. We investigated hippocampal network patterns behaving mice by developing low-dimensional embedding local field potentials recorded along CA1-to-dentate gyrus axis. This revealed layer-specific gamma profiles reflecting spatially organized rhythms their associated principal cell-interneuron firing motifs. Moreover, behaviors CA1 radial axis distinguished between deep superficial cells, as well interneurons from pyramidal, radiatum, lacunosum-moleculare layers. These findings provide comprehensive map spatiotemporal activity underlying functions.

Language: Английский

Citations

0