Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice DOI Creative Commons
Moisés dos Santos Corrêa,

Anna Agafonova,

Alexandra Braun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

SUMMARY Prosocial behaviors, such as rescuing individuals in need, are crucial for social cohesion across species. While key brain regions involved rescue behavior have been identified, the underlying neural mechanisms remain unclear. The hippocampus (HPC), known its role memory and spatial navigation, also contributes to emotional processing. However, specific involvement prosocial is not well understood. Here, we investigate causal of HPC learning executing mice. Using chemogenetics, show that dorsal (dHPC), but ventral (vHPC), essential acquiring behavior. Calcium imaging dHPC reveals network consolidation during successful rescues, with distinct synchronized ensembles activity patterns linked liberations an individual need. These findings establish a novel behavior, providing insights into empathy-driven actions.

Language: Английский

Embedding Emotion Concepts in Cognitive Maps DOI Creative Commons
Yumeng Ma,

Nilofar Vafaie,

Philip A. Kragel

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106089 - 106089

Published: March 1, 2025

Emotion knowledge is organized in a two-dimensional space known as the affective circumplex, which thought to develop from core feelings and co-occurrence of emotional events. Neural studies reveal that emotion concepts cognitive maps abstract are represented hippocampal-prefrontal systems. We propose circumplex formed by learning transitions between concepts, process mediated reciprocal network involving hippocampal cells encode grid medial entorhinal ventral prefrontal cortices relations them. anticipate testing this hypothesis will shed light on debate about whether emotions biologically basic or constructed dimensions.

Language: Английский

Citations

0
Neuronal networks in the dorsal hippocampus causally regulate rescue behavior in mice DOI Creative Commons
Moisés dos Santos Corrêa,

Anna Agafonova,

Alexandra Braun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

SUMMARY Prosocial behaviors, such as rescuing individuals in need, are crucial for social cohesion across species. While key brain regions involved rescue behavior have been identified, the underlying neural mechanisms remain unclear. The hippocampus (HPC), known its role memory and spatial navigation, also contributes to emotional processing. However, specific involvement prosocial is not well understood. Here, we investigate causal of HPC learning executing mice. Using chemogenetics, show that dorsal (dHPC), but ventral (vHPC), essential acquiring behavior. Calcium imaging dHPC reveals network consolidation during successful rescues, with distinct synchronized ensembles activity patterns linked liberations an individual need. These findings establish a novel behavior, providing insights into empathy-driven actions.

Language: Английский

Citations

0