Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

Differential effects of dopamine and serotonin on reward and punishment processes in humans: A systematic review and meta-analysis DOI Creative Commons
Anahit Mkrtchian, Zeguo Qiu, Yaniv Abir

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Importance To support treatment assignment, mechanistic biomarkers should be selectively sensitive to specific interventions. Here, we examine whether different components of reinforcement learning in humans satisfy this necessary precondition. We focus on pharmacological manipulations dopamine and serotonin that form the backbone first-line management common mental illnesses such as depression anxiety. Objective perform a meta-analysis they show distinct associations with humans. Data Sources Ovid MEDLINE/PubMed, Embase, PsycInfo databases were searched for studies published between January 1, 1946 19, 2023 (repeated April 9, 2024, October 15, 2024) investigating dopaminergic or serotonergic effects reward/punishment processes humans, according PRISMA guidelines. Study Selection Studies reporting randomized, placebo-controlled, behavioral outcome from processing task healthy included. Extraction Synthesis Standardized mean difference (SMD) scores calculated comparison each drug (dopamine/serotonin) placebo reward punishment quantified random-effects models overall four main subcategories. quality (Cochrane Collaboration’s tool), moderators, heterogeneity, publication bias also assessed. Main Outcome(s) Measure(s) Performance tasks. Results In total, 68 39 volunteers included (N =2291, N =2284; =1491, =1523). Dopamine was associated an increase (SMD=0.18, 95%CI [0.09 0.28]) but not function (SMD=-0.06, [−0.26,0.13]). Serotonin meaningfully (SMD=0.22, [−0.04,0.49]) (SMD=0.02, [−0.33,0.36]). Importantly, had subcomponents. learning/sensitivity (SMD=0.26, [0.11,0.40]), discounting (SMD=-0.08, [−0.14,-0.01]) vigor (SMD=0.32, [0.11,0.54]). By contrast, [0.05,0.59]), (SMD=-0.35, [−0.67,-0.02]), aversive Pavlovian (within-subject only; SMD=0.36, [0.20,0.53]). Conclusions Relevance Pharmacological both have measurable The selective suggests tasks could basis selective, mechanistically interpretable assignment. Key points Question Do affect humans? Findings Upregulating is increased response vigor, decreased discounting. Upregulation Meaning dissociable learning. This forms development markers

Language: Английский

Citations

0
Dopamine ‘gas pedal’ and serotonin ‘brake’ team up to accelerate learning DOI

Angie Voyles Askham

The Transmitter, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms of acupuncture in treating depression: a review DOI Creative Commons

MA Jian-fu,

Xuan Yin, Kaiyu Cui

et al.

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 3, 2025

Abstract Background Acupuncture as a representative treatment method of traditional Chinese medicine, has been found to have significant effect on mild moderate depression without obvious side effects, but the mechanism through which it exerts its antidepressant is still unclear. Methods We searched PubMed, Web Science, and Embase databases for basic research acupuncture in from database established June 14, 2024, finally included 44 studies 2020 into table analysis. The main outcomes this study are effects relevant biological indicators model. Results By analyzing rodent model depression, against was explored. In general, several methods, mainly based electroacupuncture (EA), regulate levels 5-hydroxytryptamine (5-HT), glutamic acid (Glu) dopamine (DA), calcium signaling pathway, increase expression synaptic protein, promote mitochondrial repair reduce oxidative stress, enhance plasticity. Inhibition key inflammatory pathways such P2X7R/NLRP3 NF-κB pathways, regulation hypothalamic–pituitary–adrenal axis (HPA axis) function, tryptophan metabolism improved depression-like behavior models. Conclusions summary, represented by EA multiple mechanisms play role regulating neurotransmitter balance, improving neuroplasticity, reducing responses, neuroendocrine system. However, differences between acupoint catgut embedding (ACE), manual (MA), operating parameters with different causes (such frequency, intensity, duration, etc.) need further be confirmed. This review not registered PROSPERO or other protocol registration platforms because mandatory requirement study.

Language: Английский

Citations

0
Opponent regulation of striatal output pathways by dopamine and serotonin DOI
Daniel F. Cardozo Pinto, Michaela Y. Guo,

Wade Morishita

et al.

Published: April 21, 2025

ABSTRACT Classic theories propose opponent functions for striatal dopamine (DA) and serotonin (5-hydroxytryptamine; 5HT), with DA promoting approach 5HT patience or avoidance. How these neuromodulators regulate downstream circuits to achieve such antagonistic effects remains mysterious. Here, we mapped receptor expression recorded from genetically-identified neurons demonstrate that selectively activate distinct populations of exert control over output.

Language: Английский

Citations

0
Dissociable neurofunctional and molecular characterizations of reward and punishment sensitivity DOI Creative Commons
Ting Xu,

Chunhong Zhu,

Xinqi Zhou

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 30, 2024

Abstract While the hyper-and hypo-reward or punishment sensitivities (RS, PS) have received considerable attention as prominent transdiagnostic features of psychopathology, lack an overarching neurobiological characterization currently limits their early identifications and neuromodulations. Here we combined microarray data from Allen Human Brain Atlas with a multimodal fMRI approach to uncover signatures RS PS in discovery-replication design (N=655 participants). Both were mapped separately brain, intrinsic functional connectome fronto-striatal network encoding reward responsiveness, while fronto-insular system was particularly engaged sensitivity. This dissociable patterns related also specific differentiating decisions driven by social monetary motivations. Further imaging transcriptomic analyses revealed that variations for associated topography gene sets enriched ontological pathways, including synaptic transmission, dopaminergic metabolism, immune response stress adaptation. On neurotransmitter level, serotonin neuromodulator identified pivotal hub regulating PS, this process critically dependent on its interactions dopaminergic, opioid GABAergic systems. Overall, these findings indicate neural mapping highlight linkage profiles, which may offer valuable insights into treatment evaluation symptomatology relevant reward/punishment processing deficits.

Language: Английский

Citations

0