Genetic Influence and Neural Pathways Underlying the Dose-response Relationships between Wearable-measured Physical Activity and Mental Health in Adolescence DOI
Gechang Yu, Xinran Wu,

Zhaowen Liu

et al.

Psychiatry Research, Journal Year: 2025, Volume and Issue: unknown, P. 116503 - 116503

Published: April 1, 2025

Language: Английский

Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies DOI
Roxana Andreea Moldovan, Marta R. Hidalgo, Helena Castañé

et al.

Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156241 - 156241

Published: March 1, 2025

Language: Английский

Citations

1
Faulty mitochondria jump between tumours and T cells DOI
Lucy Bird

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Mapping structural neuroimaging trajectories in bipolar disorder: neurobiological and clinical implications DOI
Nadine Parker, Christopher R. K. Ching

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Family study of bipolar disorder with comorbid anxiety disorder points to THSD7A with possible role of parent‐of‐origin effect DOI Creative Commons

Hiroaki Maki,

Naomi Sakai,

Muneko Kataoka

et al.

Psychiatry and Clinical Neurosciences Reports, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 19, 2025

The aim of this study was to provide new insights into the genetics bipolar disorder (BD) by analyzing BD comorbid with anxiety disorders. Structured interviews were conducted patients and their parents. Cases classified those spectrum (AS) without. family history AS assessed. Focusing on parent-of-origin effects genomic imprinting from results, imprinted genes tested single nucleotide polymorphisms (SNPs) in identified investigated for an association transmission disequilibrium test (TDT) using published whole-exome sequencing data. incidence among all analyzed 39.6%. Patients whose fathers had or mood disorders exhibited a significantly higher rate AS. Among known genes, two associated BD: THSD7A CACNA1C. By pruning SNPs, six variants exons four CACNA1C included analysis. these, one variant THSD7A, rs2074603, showed over-transmission parents BD. Furthermore, it nominally significant only when TDT performed separately mothers. may play role effects. Further research is necessary explore mechanisms which Clinical Trial Registration: N/A.

Language: Английский

Citations

0
Novel ABCD1 and MTHFSD Variants in Taiwanese Bipolar Disorder: A Genetic Association Study DOI Creative Commons

Yiguang Wang,

Chih-Chung Huang, Ta‐Chuan Yeh

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 486 - 486

Published: March 11, 2025

Background and Objectives: In recent years, bipolar disorder (BD), a multifaceted mood marked by severe episodic fluctuations, has been shown to have an impact on disability-adjusted life years (DALYs). The increasing prevalence of BD highlights the need for better diagnostic tools, particularly those involving genetic insights. Genetic association studies can play crucial role in identifying variations linked BD, shedding light its underpinnings potential therapeutic targets. This study aimed identify novel variants associated with Taiwanese Han population elucidate their roles disease pathogenesis. Materials Methods: Genotyping was conducted using Taiwan Precision Medicine Array (TPM Array) 128 patients 26,122 control subjects. Following quality control, 280,177 single nucleotide polymorphisms (SNPs) were analyzed via chi-square tests, linkage disequilibrium (LD) analyses employed examine associations among key SNPs. Results: Eleven SNPs reached significance (p < 10−5), variant rs11156606 ABCD1 gene—implicated fatty acid metabolism—emerging as prominent finding. LD analysis revealed that is strongly rs73640819, located 3′ untranslated region, suggesting regulatory gene expression. Additionally, rs3829533 MTHFSD found be strong missense rs3751800 rs3751801, indicating alterations protein function. Conclusion: These findings enhance understanding within cohort risk-associated support these markers early diagnosis targeted strategies.

Language: Английский

Citations

0
Genomics of Bipolar Disorder DOI
Andrew McQuillin, Roel A. Ophoff

Psychiatric Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Diversifying Psychiatric Genomics DOI
Paola Giusti‐Rodríguez,

Niran Okewole,

Sanjeev Jain

et al.

Psychiatric Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Novel multimodal precision medicine approaches and the relevance of developmental trajectories in bipolar disorder DOI Creative Commons
Olav B. Smeland,

Cecilie Busch,

Ole A. Andreassen

et al.

Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Psychiatric genetics in the diverse landscape of Latin American populations DOI
Estela M. Bruxel, Diego Luiz Rovaris, Síntia Belangero

et al.

Nature Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

0
Genetic Influence and Neural Pathways Underlying the Dose-response Relationships between Wearable-measured Physical Activity and Mental Health in Adolescence DOI
Gechang Yu, Xinran Wu,

Zhaowen Liu

et al.

Psychiatry Research, Journal Year: 2025, Volume and Issue: unknown, P. 116503 - 116503

Published: April 1, 2025

Language: Английский

Citations

0