The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era DOI Creative Commons
Yulia Desheva, Tamara Shvedova, Olga Kopteva

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 481 - 481

Published: March 27, 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent significant mutations, resulting in the Omicron variant. Methods: In this study, we analyzed blood samples from 98 patients with disease 19 (COVID-19) hospitalized during initial SARS-CoV-2 wave and onset of 2021. High-resolution melting (HRM) analysis PCR products was used to analyze RNA extracted clinical collected July November 2021 infected SARS-CoV-2. Results: HRM revealed a characteristic deletion N protein virus isolated 2021, associated Elevated levels inflammatory markers interleukin-6 (IL-6) were observed both waves COVID-19. Complement IgG IgM antibodies detected more often second wave. An increase hemagglutinin-inhibiting (HI) against influenza viruses paired specimens moderate severe COVID-19 outbreaks. Conclusions: Patients admitted showed rise markers, suggesting that triggers responses. The rapid formation may indicate faster immune response. Seasonal flu negatively impact course infections.

Language: Английский

Reduced duration of natural protection in the Omicron era DOI

Alexandra Flemming

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

Citations

0
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar DOI Creative Commons
Layan Sukik, Hiam Chemaitelly, Houssein H. Ayoub

et al.

Open Forum Infectious Diseases, Journal Year: 2025, Volume and Issue: 12(3)

Published: Feb. 17, 2025

Abstract Background Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of and evaluating effectiveness interventions. This study investigated whether SARS-CoV-2–associated hospitalizations can reliably measure true COVID-19 severity. Methods The diagnostic accuracy acute care ICU as indicators was assessed in Qatar from 6 September 2021 to 13 May 2024. WHO criteria severe, critical, fatal served reference standard. Two were assessed: (1) any hospitalization or beds (2) ICU-only hospitalizations. Results A total 644 176 infections analyzed. percent agreement between (acute ICU) 98.7% (95% confidence interval (CI), 98.6–98.7); however, Cohen's kappa only 0.17 CI, 0.16–0.18), indicating poor agreement. Sensitivity, specificity, PPV, negative predictive value 100% 99.6–100), 98.6–98.7), 9.7% 9.1–10.3), 100–100), respectively. For hospitalizations, 99.8% 99.8–99.9), with a 0.47 0.44–0.50), fair-to-good 46.6% 43.4–49.9), 99.9% 99.9–99.9), 47.9% 44.6–51.2), Conclusions Generic hospital admissions are unreliable severity, whereas somewhat more accurate. findings demonstrate importance applying specific, robust criteria—such criteria—to reduce bias epidemiological vaccine studies.

Language: Английский

Citations

0
Discordant Outcomes of SARS-CoV-2 Infection in Household Contacts DOI
Ye‐Ji Lee, Alison Tarke, Tertuliano Alves Pereira Neto

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Natural Infection of Omicron BA.5.2 in Patients Provides Broad Immune Responses Against SARS-CoV-2 DOI Creative Commons
Le Li, Feng Tang, Quan Shen

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 746 - 746

Published: March 26, 2025

The implementation of COVID-19 policy and the rapid development SARS-CoV-2 vaccines in early pandemic significantly contained numerous outbreaks reduced severity mortality COVID-19. However, population immunity induced by existing was insufficient to prevent outbreaks. host wide spread Omicron variants its influence on emerging are attracting broad attention. In this study, a clinical data analysis patients indicated that pre-vaccination inflammatory responses mitigated cases caused natural infection with BA.5.2. adaptive immune BA.5.2 robust responses, including both humoral T cell-mediated (IFN-γ) against highly conserved viral antigens, provided cross-reactive neutralization various variants. Collectively, we report variants, which suggests live attenuated vaccine desired safety, high efficacy, spectrum, long-term persistence is feasible. Therefore, suggest herd immunity, achieved through vaccination vaccines, combined booster doses antiviral therapy for people loads, may contribute eradication virus.

Language: Английский

Citations

0
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities DOI Creative Commons
Layan Sukik, Hiam Chemaitelly, Houssein H. Ayoub

et al.

BMJ Open Respiratory Research, Journal Year: 2025, Volume and Issue: 12(1), P. e002718 - e002718

Published: March 1, 2025

Background SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this across different reinfection symptoms and severities, comparing the preomicron omicron eras. Methods A nationwide, matched, test-negative, case–control was conducted in Qatar from 5 February 2020 to 12 March 2024. The analysis used a sample of 509 949 positive 8 494 782 negative tests, while included 682 257 6 904 044 tests. Data were sourced Qatar’s national databases for COVID-19 laboratory testing, vaccination, hospitalisation death. Results Effectiveness estimated at 80.9% (95% CI: 79.1% 82.6%) asymptomatic reinfection, 87.5% 86.1% 88.9%) symptomatic 97.8% 95.7% 98.9%) severe 100.0% 97.5% 100.0%) critical 88.1% 50.3% 97.2%) fatal For estimates 46.4% 36.9% 54.4%) 52.8% 44.4% 60.0%) 55.4% 15.1% 75.2% −58.8% 97.5%) over time since previous showed no discernible decline all forms era, but rapid reinfections era. Conclusions gradient evident, highest observed COVID-19. Over time, becomes more pronounced, as decreases, outcomes remains strong.

Language: Английский

Citations

0
Longitudinal cellular and humoral immune responses following COVID-19 BNT162b2-mRNA-based booster vaccination of craft and manual workers in Qatar DOI Creative Commons

Remy Thomas,

Ahmed Zaqout,

Bakhita Meqbel

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Background In March 2020, the rapid spread of SARS-CoV-2 prompted global vaccination campaigns to mitigate COVID-19 disease severity and mortality. The 2-dose BNT162b2-mRNA vaccine effectively reduced infection mortality rates, however, waning effectiveness necessitated introduction a third dose or booster. Aim To assess magnitude longevity booster-induced immunity, we conducted longitudinal study specific cellular humoral immune responses among Qatar’s vulnerable craft manual worker community. We also investigated impact prior naturally acquired immunity on booster efficacy. Methods Seventy healthy participants were enrolled in study, whom half had infection. Blood samples collected before after evaluate through ELISpots, IgG ELISA, neutralization assays, flow cytometric immunophenotyping. Results T cell analysis revealed increased Th1 cytokine responses, marked by enhanced IFN-γ release, recently infected participants, which was further for up 6-months. Furthermore, stimulated cytotoxic infection-naïve characterized granzyme B production. Both natural induced robust durable with high neutralizing antibody levels. Prior linked an number class-switched cells vaccination. Conclusions These findings underscore importance enhancing anti-viral across both previously individuals, distinct arms response prolonging immunity.

Language: Английский

Citations

0
The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era DOI Creative Commons
Yulia Desheva, Tamara Shvedova, Olga Kopteva

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 481 - 481

Published: March 27, 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent significant mutations, resulting in the Omicron variant. Methods: In this study, we analyzed blood samples from 98 patients with disease 19 (COVID-19) hospitalized during initial SARS-CoV-2 wave and onset of 2021. High-resolution melting (HRM) analysis PCR products was used to analyze RNA extracted clinical collected July November 2021 infected SARS-CoV-2. Results: HRM revealed a characteristic deletion N protein virus isolated 2021, associated Elevated levels inflammatory markers interleukin-6 (IL-6) were observed both waves COVID-19. Complement IgG IgM antibodies detected more often second wave. An increase hemagglutinin-inhibiting (HI) against influenza viruses paired specimens moderate severe COVID-19 outbreaks. Conclusions: Patients admitted showed rise markers, suggesting that triggers responses. The rapid formation may indicate faster immune response. Seasonal flu negatively impact course infections.

Language: Английский

Citations

0