Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations DOI Open Access
Boya Guo, Yanwei Cai, Daeeun Kim

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry among 244,637 cases and 637,891 controls eight from Population Architecture Genomics Epidemiology (PAGE) Study 13 additional biobanks cohorts. performance was context dependent, with better those who were younger, male, family history T2D, without hypertension, not obese or overweight. Additionally, associated diabetes-related cardiometabolic traits complications, suggesting its utility stratifying complications shared genetic architecture between other diseases. These findings highlight need account when evaluating as tool prognostication potentially generalizable associations despite differential prediction populations.

Language: Английский

How centuries of isolation shaped Greenlanders’ unique genetics DOI

Freda Kreier

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

0
Genetic data from Indigenous Greenlanders could help to narrow health-care gap DOI
Laura Arbour

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

0
Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations DOI Open Access
Boya Guo, Yanwei Cai, Daeeun Kim

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry among 244,637 cases and 637,891 controls eight from Population Architecture Genomics Epidemiology (PAGE) Study 13 additional biobanks cohorts. performance was context dependent, with better those who were younger, male, family history T2D, without hypertension, not obese or overweight. Additionally, associated diabetes-related cardiometabolic traits complications, suggesting its utility stratifying complications shared genetic architecture between other diseases. These findings highlight need account when evaluating as tool prognostication potentially generalizable associations despite differential prediction populations.

Language: Английский

Citations

0