Mechanism-based nonopioid analgesic targets DOI Creative Commons

Xiangsunze Zeng,

Rasheen Powell, Clifford J. Woolf

et al.

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(11)

Published: June 1, 2025

Acute pain management has historically been dominated by opioids, whose efficacy is overshadowed the risks of addiction, tolerance, and dependence, culminating in global opioid crisis. To transcend this issue, we must innovate beyond opioid-based μ receptor treatments, identifying nonopioid analgesics with high minimal adverse effects. This Review navigates multifaceted landscape inflammatory, neuropathic, nociplastic pain, emphasizing mechanism-based analgesic targets tailored to specific conditions. We delve into challenges breakthroughs clinical trials targeting ion channels, GPCRs, other molecular targets. also highlight intricate crosstalk between different physiological systems need for multimodal interventions distinct pharmacodynamics manage acute chronic respectively. Furthermore, explore emerging strategies, including gene therapy, stem cell type-specific neuromodulation, AI-driven techniques objective, unbiased assessment research. These innovative approaches are poised revolutionize management, paving way discovery safer more effective analgesics.

Language: Английский

Inhibition of Circadian Rhythm Gene per1 Promotes Macrophage Infiltration in e-Cigarette Aerosol-Induced Pulmonary Fibrosis in Mice DOI Creative Commons

Cuishuang Dong,

Bin Li, Cong Liu

et al.

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

Citations

0
Mechanism-based nonopioid analgesic targets DOI Creative Commons

Xiangsunze Zeng,

Rasheen Powell, Clifford J. Woolf

et al.

Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(11)

Published: June 1, 2025

Acute pain management has historically been dominated by opioids, whose efficacy is overshadowed the risks of addiction, tolerance, and dependence, culminating in global opioid crisis. To transcend this issue, we must innovate beyond opioid-based μ receptor treatments, identifying nonopioid analgesics with high minimal adverse effects. This Review navigates multifaceted landscape inflammatory, neuropathic, nociplastic pain, emphasizing mechanism-based analgesic targets tailored to specific conditions. We delve into challenges breakthroughs clinical trials targeting ion channels, GPCRs, other molecular targets. also highlight intricate crosstalk between different physiological systems need for multimodal interventions distinct pharmacodynamics manage acute chronic respectively. Furthermore, explore emerging strategies, including gene therapy, stem cell type-specific neuromodulation, AI-driven techniques objective, unbiased assessment research. These innovative approaches are poised revolutionize management, paving way discovery safer more effective analgesics.

Language: Английский

Citations

0