Complete sequencing of ape genomes DOI Creative Commons
DongAhn Yoo, Arang Rhie,

Prajna Hebbar

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies 1–3 . Consequently, our understanding the evolution species is incomplete. Here we present haplotype-resolved reference analyses six species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) completely 215 gapless chromosomes telomere-to-telomere. resolve challenging regions, such as major histocompatibility complex immunoglobulin loci, to provide in-depth evolutionary insights. Comparative enabled investigations diversity previously uncharacterized or incompletely studied without bias mapping human genome. Such include newly minted gene families lineage-specific segmental duplications, centromeric DNA, acrocentric subterminal heterochromatin. This resource serves a comprehensive baseline for future humans closest living relatives.

Language: Английский

Complete sequencing of ape genomes DOI Creative Commons
DongAhn Yoo, Arang Rhie,

Prajna Hebbar

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract The most dynamic and repetitive regions of great ape genomes have traditionally been excluded from comparative studies 1–3 . Consequently, our understanding the evolution species is incomplete. Here we present haplotype-resolved reference analyses six species: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan siamang. We achieve chromosome-level contiguity with substantial sequence accuracy (<1 error in 2.7 megabases) completely 215 gapless chromosomes telomere-to-telomere. resolve challenging regions, such as major histocompatibility complex immunoglobulin loci, to provide in-depth evolutionary insights. Comparative enabled investigations diversity previously uncharacterized or incompletely studied without bias mapping human genome. Such include newly minted gene families lineage-specific segmental duplications, centromeric DNA, acrocentric subterminal heterochromatin. This resource serves a comprehensive baseline for future humans closest living relatives.

Language: Английский

Citations

2