Adjuvant personalized cancer vaccine: is this the end of metastatic kidney cancer

Nature Reviews Urology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

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Mapping the functional differentiation and interactions among the inferior, medial frontal and posterior temporal cortex in semantic control

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Semantic control refers to the ability flexibly retrieve and manipulate stored knowledge support context-appropriate behavior. A left-lateralized network comprising left inferior frontal gyrus (IFG), posterior middle temporal (pMTG), dorsal medial prefrontal cortex (dmPFC) has been consistently implicated in this process. While previous studies have established necessity of IFG pMTG semantic control, causal role dmPFC remains unclear. Additionally, it is unknown whether each these three regions exhibits internal functional differentiation how they interact control. To address questions, we combined task-based magnetic resonance imaging (fMRI) with fMRI-guided transcranial stimulation (TMS). We found that dmPFC, like pMTG, causally involved All exhibited a consistent anterior–posterior gradient: anterior subregions were selectively engaged during high-demand processing, whereas responded both easy hard tasks. Furthermore, activation patterns better predicted behavioral differences between tasks compared any single region. modulated autoinhibition within individual connectivity among them, suggesting operate coordinated rather than isolation. These findings advance our understanding neural architecture supporting flexible Significance Statement Understanding brain supports behavior critical for cognitive neuroscience clinical neuropsychology. prior IFG, contribution dynamics remained This study provides first evidence dmPFC’s reveals shows as an integrated network. challenge notion functionally homogeneous nodes highlight topographically organized, interactive system underlying controlled retrieval. work refines mechanistic may inform models language conceptual deficits.

Language: Английский

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Personalized neoantigen vaccines in urologic malignancies

Nature Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

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