Oncolytic viruses: a promising therapy for malignant pleural effusion and solid tumors DOI Creative Commons
Xinya Wang,

Qin Zhou,

X L Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Oncolytic viruses (OVs) are natural or recombinant that can directly lyse tumor cells without damaging normal cells. They enhance anti-tumor immunity by releasing antigens and activating inflammatory responses within the microenvironment (TME). This offers a new therapeutic approach for MPE solid tumors. review discusses progress of OVs administered via intrapleural intratumoral routes, emphasizing their potential in treatment challenges posed complex environment, which affects direct interaction between OVs, cells, immune also regulatory barriers, safety concerns accessibility oncolytic virus therapy.

Language: Английский

The diversity of CD8+ T cell dysfunction in cancer and viral infection DOI
Lorenzo Galluzzi, Kellie N. Smith, Adrian Liston

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

0
Oncolytic viruses: a promising therapy for malignant pleural effusion and solid tumors DOI Creative Commons
Xinya Wang,

Qin Zhou,

X L Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 25, 2025

Oncolytic viruses (OVs) are natural or recombinant that can directly lyse tumor cells without damaging normal cells. They enhance anti-tumor immunity by releasing antigens and activating inflammatory responses within the microenvironment (TME). This offers a new therapeutic approach for MPE solid tumors. review discusses progress of OVs administered via intrapleural intratumoral routes, emphasizing their potential in treatment challenges posed complex environment, which affects direct interaction between OVs, cells, immune also regulatory barriers, safety concerns accessibility oncolytic virus therapy.

Language: Английский

Citations

0