Comparative connectomics of Drosophila descending and ascending neurons DOI Creative Commons
Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical an information bottleneck connecting brain ventral cord (an analogue spinal cord) comprises diverse populations descending neurons (DNs), ascending (ANs) sensory neurons, are crucial sensorimotor signalling control. Here, by integrating three separate electron microscopy (EM) datasets1-4, we provide complete connectomic description ANs DNs Drosophila female system compare them with male cord. Proofread neuronal reconstructions matched across hemispheres, datasets sexes. Crucially, also match 51% DN cell types to light-level data5 defining specific driver lines, as well classifying all populations. We use these results reveal circuit logic neurons. observe connected chains spanning neck, may subserve sequences. sexually dimorphic AN populations, detailed analyses selected circuits reproductive behaviours, including courtship6 (DNa12; known aSP22) song production7 (AN from hemilineage 08B) ovipositor extrusion8 (DNp13). Our work provides EM-level that span entire central adult animal.

Language: Английский

Relationships and representations of brain structures, connectivity, dynamics and functions DOI
Oliver Schmitt

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111332 - 111332

Published: March 1, 2025

Language: Английский

Citations

0
Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation DOI Creative Commons
Dunxin Shen, Alec Vincent,

Evan Udine

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: unknown, P. 115459 - 115459

Published: April 1, 2025

Neurodegenerative diseases are characterized by the localized loss of neurons. Why cell death is triggered only in specific neuronal populations and whether it response to toxic insults or initial cellular state that determines their vulnerability unknown. To understand individual responses disease, we profiled transcriptional signatures throughout disease development a Drosophila model C9orf72 (G4C2) repeat expansion (C9), most common genetic cause frontotemporal dementia amyotrophic lateral sclerosis. We identified specifically vulnerable resistant C9 expression found an upregulation protein homeostasis pathways neurons at baseline. Overexpression Xbp1s, key regulator unfolded central node resistance network, rescues toxicity. This study shows depends on intrinsic leveraging neurons' properties can boost

Language: Английский

Citations

0
Comparative connectomics of Drosophila descending and ascending neurons DOI Creative Commons
Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

In most complex nervous systems there is a clear anatomical separation between the nerve cord, which contains of final motor outputs necessary for behaviour, and brain. insects, neck connective both physical an information bottleneck connecting brain ventral cord (an analogue spinal cord) comprises diverse populations descending neurons (DNs), ascending (ANs) sensory neurons, are crucial sensorimotor signalling control. Here, by integrating three separate electron microscopy (EM) datasets1-4, we provide complete connectomic description ANs DNs Drosophila female system compare them with male cord. Proofread neuronal reconstructions matched across hemispheres, datasets sexes. Crucially, also match 51% DN cell types to light-level data5 defining specific driver lines, as well classifying all populations. We use these results reveal circuit logic neurons. observe connected chains spanning neck, may subserve sequences. sexually dimorphic AN populations, detailed analyses selected circuits reproductive behaviours, including courtship6 (DNa12; known aSP22) song production7 (AN from hemilineage 08B) ovipositor extrusion8 (DNp13). Our work provides EM-level that span entire central adult animal.

Language: Английский

Citations

0