Nature Communications,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: Feb. 3, 2020
Each
additional
copy
of
the
apolipoprotein
E4
(APOE4)
allele
is
associated
with
a
higher
risk
Alzheimer's
dementia,
while
APOE2
lower
it
not
yet
known
whether
homozygotes
have
particularly
low
risk.
We
generated
dementia
odds
ratios
and
other
findings
in
more
than
5,000
clinically
characterized
neuropathologically
cases
controls.
APOE2/2
was
compared
to
APOE2/3
3/3,
an
exceptionally
ratio
APOE4/4,
impact
APOE4
gene
dose
significantly
greater
confirmed
group
24,000
unconfirmed
Finding
targeting
factors
by
which
APOE
its
variants
influence
disease
could
major
on
understanding,
treatment
prevention
disease.
Circulation,
Journal Year:
2023,
Volume and Issue:
147(8)
Published: Jan. 25, 2023
Background:
The
American
Heart
Association,
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
diet,
weight)
factors
(cholesterol,
blood
pressure,
glucose
control)
that
contribute
health.
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
congenital
rhythm
disorders,
subclinical
atherosclerosis,
coronary
failure,
valvular
venous
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
Methods:
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
provide
current
information
available
annual
review
published
literature
year
before
writing.
2023
is
product
full
year’s
worth
effort
2022
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
Association
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
COVID-19
(coronavirus
2019)
publications,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
Results:
Each
chapters
focuses
different
topic
statistics.
Conclusions:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
Nature Genetics,
Journal Year:
2022,
Volume and Issue:
54(4), P. 412 - 436
Published: April 1, 2022
Abstract
Characterization
of
the
genetic
landscape
Alzheimer’s
disease
(AD)
and
related
dementias
(ADD)
provides
a
unique
opportunity
for
better
understanding
associated
pathophysiological
processes.
We
performed
two-stage
genome-wide
association
study
totaling
111,326
clinically
diagnosed/‘proxy’
AD
cases
677,663
controls.
found
75
risk
loci,
which
42
were
new
at
time
analysis.
Pathway
enrichment
analyses
confirmed
involvement
amyloid/tau
pathways
highlighted
microglia
implication.
Gene
prioritization
in
loci
identified
31
genes
that
suggestive
genetically
processes,
including
tumor
necrosis
factor
alpha
pathway
through
linear
ubiquitin
chain
assembly
complex.
also
built
score
with
future
AD/dementia
or
progression
from
mild
cognitive
impairment
to
AD/dementia.
The
improvement
prediction
led
1.6-
1.9-fold
increase
lowest
highest
decile,
addition
effects
age
APOE
ε4
allele.
Molecular Psychiatry,
Journal Year:
2021,
Volume and Issue:
26(10), P. 5481 - 5503
Published: Aug. 30, 2021
Abstract
Breakthroughs
in
molecular
medicine
have
positioned
the
amyloid-β
(Aβ)
pathway
at
center
of
Alzheimer’s
disease
(AD)
pathophysiology.
While
detailed
mechanisms
and
spatial-temporal
dynamics
leading
to
synaptic
failure,
neurodegeneration,
clinical
onset
are
still
under
intense
investigation,
established
biochemical
alterations
Aβ
cycle
remain
core
biological
hallmark
AD
promising
targets
for
development
disease-modifying
therapies.
Here,
we
systematically
review
update
vast
state-of-the-art
literature
science
with
evidence
from
basic
research
studies
human
genetic
multi-modal
biomarker
investigations,
which
supports
a
crucial
role
dyshomeostasis
pathophysiological
dynamics.
We
discuss
highlighting
differentiated
interaction
distinct
species
other
AD-related
mechanisms,
such
as
tau-mediated,
neuroimmune
inflammatory
changes,
well
neurochemical
imbalance.
Through
lens
latest
multimodal
vivo
biomarkers
AD,
this
cross-disciplinary
examines
compelling
hypothesis-
data-driven
rationale
Aβ-targeting
therapeutic
strategies
early
treatment
AD.
Circulation,
Journal Year:
2024,
Volume and Issue:
149(8)
Published: Jan. 24, 2024
BACKGROUND:
The
American
Heart
Association
(AHA),
in
conjunction
with
the
National
Institutes
of
Health,
annually
reports
most
up-to-date
statistics
related
to
heart
disease,
stroke,
and
cardiovascular
risk
factors,
including
core
health
behaviors
(smoking,
physical
activity,
nutrition,
sleep,
obesity)
factors
(cholesterol,
blood
pressure,
glucose
control,
metabolic
syndrome)
that
contribute
health.
AHA
Disease
Stroke
Statistical
Update
presents
latest
data
on
a
range
major
clinical
circulatory
disease
conditions
(including
brain
health,
complications
pregnancy,
kidney
congenital
rhythm
disorders,
sudden
cardiac
arrest,
subclinical
atherosclerosis,
coronary
cardiomyopathy,
failure,
valvular
venous
thromboembolism,
peripheral
artery
disease)
associated
outcomes
quality
care,
procedures,
economic
costs).
METHODS:
AHA,
through
its
Epidemiology
Prevention
Statistics
Committee,
continuously
monitors
evaluates
sources
stroke
United
States
globally
provide
current
information
available
annual
review
published
literature
year
before
writing.
2024
is
product
full
year’s
worth
effort
2023
by
dedicated
volunteer
clinicians
scientists,
committed
government
professionals,
staff
members.
strives
further
understand
help
heal
problems
inflicted
structural
racism,
public
crisis
can
significantly
damage
mental
perpetuate
disparities
access
education,
income,
housing,
several
other
vital
healthy
lives.
This
edition
includes
additional
global
data,
as
well
monitoring
benefits
population,
an
enhanced
focus
equity
across
key
domains.
RESULTS:
Each
chapters
focuses
different
topic
statistics.
CONCLUSIONS:
represents
critical
resource
for
lay
public,
policymakers,
media
clinicians,
care
administrators,
researchers,
advocates,
others
seeking
best
these
conditions.
