Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: March 31, 2023
Abstract
A
growing
body
of
evidence
suggests
that
dysbiosis
the
human
gut
microbiota
is
associated
with
neurodegenerative
diseases
like
Alzheimer’s
disease
(AD)
via
neuroinflammatory
processes
across
microbiota-gut-brain
axis.
The
affects
brain
health
through
secretion
toxins
and
short-chain
fatty
acids,
which
modulates
permeability
numerous
immune
functions.
Observational
studies
indicate
AD
patients
have
reduced
microbiome
diversity,
could
contribute
to
pathogenesis
disease.
Uncovering
genetic
basis
microbial
abundance
its
effect
on
suggest
lifestyle
changes
may
reduce
an
individual’s
risk
for
Using
largest
genome-wide
association
study
genera
from
MiBioGen
consortium,
we
used
polygenic
score
(PRS)
analyses
“best-fit”
model
implemented
in
PRSice-2
determined
correlation
between
119
a
discovery
sample
(ADc12
case/control:
1278/1293).
To
confirm
results
sample,
next
repeated
PRS
analysis
replication
(GenADA
799/778)
then
performed
meta-analysis
both
samples.
Finally,
conducted
linear
regression
assess
PRSs
significant
APOE
genotypes.
In
20
were
initially
identified
as
genetically
case/control
status.
Of
these
20,
three
(
Eubacterium
fissicatena
protective
factor
,
Collinsella,
Veillonella
factor)
independently
sample.
Meta-analysis
samples
confirmed
ten
had
AD,
four
significantly
rs429358
allele
direction
consistent
their
protective/risk
designation
association.
Notably,
proinflammatory
genus
was
positively
correlated
Overall,
host
factors
influencing
are
suggesting
serve
biomarkers
targets
treatment
intervention.
Our
highlight
might
promote
development
interaction
.
Larger
datasets
functional
required
understand
causal
relationships.
BMC Medicine,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Nov. 15, 2022
Abstract
Background
Several
recent
observational
studies
have
reported
that
gut
microbiota
composition
is
associated
with
preeclampsia.
However,
the
causal
effect
of
on
preeclampsia-eclampsia
unknown.
Methods
A
two-sample
Mendelian
randomization
study
was
performed
using
summary
statistics
from
largest
available
genome-wide
association
meta-analysis
(
n
=13,266)
conducted
by
MiBioGen
consortium.
The
were
obtained
FinnGen
consortium
R7
release
data
(5731
cases
and
160,670
controls).
Inverse
variance
weighted,
maximum
likelihood,
MR-Egger,
weighted
median,
model,
MR-PRESSO,
cML-MA
used
to
examine
between
preeclampsia-eclampsia.
Reverse
analysis
bacteria
found
be
causally
in
forward
analysis.
Cochran’s
Q
quantify
heterogeneity
instrumental
variables.
Results
estimates
suggested
Bifidobacterium
had
a
protective
(odds
ratio
=
0.76,
95%
confidence
interval:
0.64–0.89,
P
8.03
×
10
−4
).
In
addition,
Collinsella
0.77,
0.60–0.98,
0.03),
Enterorhabdus
0.62–0.93,
8.76
−3
),
Eubacterium
(ventriosum
group)
0.63–0.91,
2.43
Lachnospiraceae
(NK4A136
0.65–0.92,
3.77
Tyzzerella
3
0.85,
0.74–0.97,
0.01)
presented
suggestive
According
results
reverse
MR
analysis,
no
significant
microbiota.
No
variables
or
horizontal
pleiotropy
found.
Conclusions
This
Further
randomized
controlled
trials
are
needed
clarify
probiotics
their
specific
mechanisms.
BMC Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Feb. 21, 2023
Abstract
Background
Evidence
from
observational
studies
and
clinical
trials
suggests
that
the
gut
microbiota
is
associated
with
cancer.
However,
causal
association
between
cancer
remains
to
be
determined.
Methods
We
first
identified
two
sets
of
based
on
phylum,
class,
order,
family,
genus
level
information,
data
were
obtained
IEU
Open
GWAS
project.
then
performed
two-sample
Mendelian
randomisation
(MR)
determine
whether
causally
eight
types.
Furthermore,
we
a
bi-directional
MR
analysis
examine
direction
relations.
Results
11
relationships
genetic
liability
in
microbiome
cancer,
including
those
involving
Bifidobacterium
.
found
17
strong
associations
Moreover,
24
using
multiple
datasets.
Conclusions
Our
revealed
was
cancers
may
useful
providing
new
insights
for
further
mechanistic
microbiota-mediated
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Dec. 6, 2022
Depression
is
one
of
the
most
poorly
understood
diseases
due
to
its
elusive
pathogenesis.
There
an
urgency
identify
molecular
and
biological
mechanisms
underlying
depression
gut
microbiome
a
novel
area
interest.
Here
we
investigate
relation
fecal
diversity
composition
with
depressive
symptoms
in
1,054
participants
from
Rotterdam
Study
cohort
validate
these
findings
Amsterdam
HELIUS
1,539
subjects.
We
association
thirteen
microbial
taxa,
including
genera
Eggerthella,
Subdoligranulum,
Coprococcus,
Sellimonas,
Lachnoclostridium,
Hungatella,
Ruminococcaceae
(UCG002,
UCG003
UCG005),
LachnospiraceaeUCG001,
Eubacterium
ventriosum
Ruminococcusgauvreauiigroup,
family
symptoms.
These
bacteria
are
known
be
involved
synthesis
glutamate,
butyrate,
serotonin
gamma
amino
butyric
acid
(GABA),
which
key
neurotransmitters
for
depression.
Our
study
suggests
that
may
play
role
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 24, 2022
Growing
evidence
has
shown
that
alterations
in
gut
microbiota
composition
are
associated
with
multiple
autoimmune
diseases
(ADs).
However,
it
is
unclear
whether
these
associations
reflect
a
causal
relationship.
Science,
Journal Year:
2021,
Volume and Issue:
373(6551), P. 181 - 186
Published: July 9, 2021
Baboons
inform
on
human
gut
microbiota
Commensal
bacteria
are
found
throughout
an
organism,
but
it
is
not
known
whether
associations
between
and
their
host
heritable.
Grieneisen
et
al.
examined
changes
in
the
microbiomes
of
585
wild
baboons
from
fecal
samples
collected
over
14
years
(see
Perspective
by
Cortes-Ortiz
Amato).
Almost
all
microbiome
traits
tested
demonstrated
some
level
statistically
significant
heritability.
Most
heritability
values
were
low
varied
time
correlating
with
age
host.
live
environment
similar
to
that
postulated
for
early
humans
have
a
humans.
Thus,
this
may
reflect
genetic
determinants
humans,
which
datasets
available.
Science
,
aba5483,
issue
p.
181
;
see
also
abj5287,
159
